Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study

Abdelrahman, Mahmoud A. E.; Alkady, Eman A.M.; Ahmed, Sameh

doi:10.1016/j.ejphar.2015.06.014

Cited by 25 publications

(14 citation statements)

References 31 publications

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“…Another focus for potential synergy between vitamin K and vitamin D represents the above mentioned morphogenic protein Bnp-2, the expression of which is regulated by both MGP and calcitriol [39,45]. It has been also reported, that vitamin K 2 treatment inhibits expression of some MMPs both, in experimental and in clinical studies [46,47]. Thus, vitamins K and D can mutually enhance each other´s physiological role and our results provided a plausible clinical correlate to these solely experimental findings.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Synergistic effect of low K and D vitamin status on arterial stiffness in a general population

Mayer

Seidlerová

Wohlfahrt

et al. 2017

The Journal of Nutritional Biochemistry

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Section: Accepted Manuscriptmentioning

confidence: 98%

Synergistic effect of low K and D vitamin status on arterial stiffness in a general population

Mayer

Seidlerová

Wohlfahrt

et al. 2017

The Journal of Nutritional Biochemistry

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“…Vitamin K2 may induce apoptosis in rheumatoid arthritis synovial cells. In a cross-sectional study (LOE = B), the group given 100 μ gm of MK-7 had a significant reduction in disease activity score along with improved biochemical markers (ESR, CRP, and matrix metalloproteinase) after 3 months [27]. …”

Section: Vitamin K and Arthritismentioning

confidence: 99%

Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health

Schwalfenberg

2017

Journal of Nutrition and Metabolism

120

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Objective To review the evidence for the use of vitamin K supplementation in clinical conditions such as osteoporosis, vascular calcification, arthritis, cancer, renal calculi, diabetes, and warfarin therapy. Quality of Evidence PubMed was searched for articles on vitamin K (K1 and K2) along with books and conference proceedings and health conditions listed above. Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease. Evidence is insufficient for use in diabetes, arthritis, renal calculi, and cancer. Main Message Vitamin K2 may be a useful adjunct for the treatment of osteoporosis, along with vitamin D and calcium, rivaling bisphosphonate therapy without toxicity. It may also significantly reduce morbidity and mortality in cardiovascular health by reducing vascular calcification. Vitamin K2 appears promising in the areas of diabetes, cancer, and osteoarthritis. Vitamin K use in warfarin therapy is safe and may improve INR control, although a dosage adjustment is required. Conclusion Vitamin K supplementation may be useful for a number of chronic conditions that are afflicting North Americans as the population ages. Supplementation may be required for bone and cardiovascular health.

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“…A clinical study on the effects of vitamin K2 supplementation in the treatment of RA used 100µg/day of menaquinone-7 for three months without changing the established medication regime of RA patients. At the end of the study, the vitamin K2 supplemented group showed a significant decrease in erythrocyte sedimentation rate, C-reactive protein (CRP), matrix metalloproteinase (MMP-3), and clinical disease score among other markers [70]. An additional study with 45mg/day of vitamin K2 supplementation in RA patients showed a decrease in serum CRP and MMP-3.…”

Section: Vitamin Kmentioning

confidence: 94%

Psoriasis and Fat-soluble Vitamins: A Review

Usedom¹,

Neidig²,

Allen³

2017

J Clin Exp Dermatol Res

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Fat-soluble vitamins exhibit numerous routes of immune modulation and specifically alter a variety of pathways in psoriasis pathology. Psoriasis, a chronic immune-mediated disease, often requires a combination of topical, oral, and occasionally, subcutaneous or intravenous therapies making disease management complex. With the complexity of treatment, patient adherence is reduced. Vitamin supplementation as an adjunctive treatment would minimize potential adverse effects from systemic medication, increase patient adherence and decrease overall cost. While vitamin A and D are effective topically, oral supplementation is not currently a mainstay of therapy although data exists to support such supplementation. Data on vitamin E and K implicate the significant role each has in the alteration of the inflammatory cascade responsible for psoriasis. Research showing fat-soluble vitamin deficiency in psoriasis exists and presents greater evidence for oral vitamin treatment in addition to first-line therapies. This review presents the mechanism of action in psoriasis of each fat-soluble vitamin and the data on the efficacy of oral fat-soluble vitamin supplementation in psoriasis and systemic inflammation. We also present fat-soluble vitamin deficiency data shown in psoriasis patients. With the evidence of their targeted mechanism of action, efficacy data with oral supplementation, and evidence of deficiency in patients, oral fat-soluble vitamins should be considered as an adjunct to therapy in psoriasis patients.

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Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study

Cited by 25 publications

References 31 publications

Synergistic effect of low K and D vitamin status on arterial stiffness in a general population

Synergistic effect of low K and D vitamin status on arterial stiffness in a general population

Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health

Psoriasis and Fat-soluble Vitamins: A Review

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