2020
DOI: 10.1101/2020.06.30.181438
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Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

Abstract: AbstractThe gut microbiome has been implicated in a variety of physiological states. Controversy over causality, however, has always haunted microbiome studies. Here, we utilized the bidirectional Mendelian randomization (MR) approach to address questions that are not yet mature for more costly randomized interventions. From a total of 3,432 Chinese individuals with shotgun sequencing data for whole genome and whole metagenome, as well as anthropometric and blood metabolic trai… Show more

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Cited by 7 publications
(7 citation statements)
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“…It also confirms reports from two very recent studies: the first of these studies, a meta-analysis across five German cohorts, using 16S rRNA sequencing to characterize the gut microbiota, linked Bacteroides and Faecalibacterium to ABO and FUT2 79 . The second study, taking a functional approach, intriguingly associated bacterial lactose and galactose degradation genes to ABO variation in a cohort of 3,432 Chinese individuals 80 . Taken together, these findings suggest a broad association of ABO polymorphisms with microbial variation in various human populations.…”
Section: Discussionmentioning
confidence: 99%
“…It also confirms reports from two very recent studies: the first of these studies, a meta-analysis across five German cohorts, using 16S rRNA sequencing to characterize the gut microbiota, linked Bacteroides and Faecalibacterium to ABO and FUT2 79 . The second study, taking a functional approach, intriguingly associated bacterial lactose and galactose degradation genes to ABO variation in a cohort of 3,432 Chinese individuals 80 . Taken together, these findings suggest a broad association of ABO polymorphisms with microbial variation in various human populations.…”
Section: Discussionmentioning
confidence: 99%
“…in China. The protocols for blood and oral collection, as well as the whole genome and metagenomic sequencing were similar to our previous literature 5,23,48 . For blood sample, DNA was extracted using MagPure Buffy Coat DNA Midi KF Kit (no.…”
Section: Methodsmentioning
confidence: 83%
“…3,932 (2,017 tongue dorsum and 1,915 saliva) oral samples from this cohort were newly collected for whole metagenomic sequencing between 2017 to 2018 ( Supplementary Table 1 ). The protocols for blood and oral collection, as well as the whole genome and metagenomic sequencing were similar to our previous literature 5,23,42 . For blood sample, DNA was extracted using MagPure Buffy Coat DNA Midi KF Kit (no.…”
Section: Methodsmentioning
confidence: 83%
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“…Associations with microbiome composition at the ABO locus have been reported previously for populations of different ethnicities and in nonhuman species. For example, associations with Bacteroides and Faecalibacterium were reported in a study of five German cohorts that used 16S rRNA sequencing for gut microbiome characterization 28 and with the microbial pathway of lactose and galactose degradation in a cohort of 3,432 Chinese individuals 31 . The importance of ABO in determining host-microbiome interaction has also been recently reported in pigs 32 .…”
Section: Discussionmentioning
confidence: 99%