Ménétrier Disease and Gastric Adenocarcinoma in 3 Cairn Terrier Littermates

Abstract

Ménétrier disease is a rare hypertrophic gastropathy that is characterized by hyperplasia of the mucous cells with concurrent loss of chief and parietal cells within the gastric glands. There are few reports of this disease in dogs, and little is known about the clinical presentation and progression of canine Ménétrier disease. Three Cairn terrier littermates developed hypertrophic gastropathy with histological features of Ménétrier disease. One dog remained clinically asymptomatic for 2 years after diagnosis. The development of this disease in 3 siblings suggests a possible inherited predisposition. All 3 dogs also developed gastric neoplasia, which has been reported in human Ménétrier disease but has not been associated previously with hypertrophic gastropathy in domestic species.

Gastric carcinoma associated with Menetrier's‐like disease in a West Highland white terrier

“…Five years after the first admission, endoscopic and ultrasonographic examination confirmed a recurrence of hypertrophic changes in the gastric wall (in a more diffuse form this time), with modifications of the mucosa. Histology confirmed gastric hypertropy but also revealed a carcinomatous infiltration, establishing coexistence of lesions of Ménétrier and carcinoma, as reported by Munday and others ().…”

“…Human Ménétrier's disease is a rare hypertrophic gastropathy, characterised by hyperplasia of gastric mucosal cells, resulting in large gastric folds in the body of the stomach, usually sparing the oesophagocardiac area and the antrum but associated with hypoalbuminaemia and hypochloraemia (Ménétrier ). Few cases have been reported in dogs (Van der Gaag and others , Rallis and others , Munday and others ) and anorexia, weight loss and vomiting are frequent in the canine form. Humans with Ménétrier's disease are thought to have an increased risk of developing gastric carcinoma, but this association is still unclear (Wood and others , Roseau and others , Jouini and others ).…”

Gastric carcinoma in canines and humans, a review

“…In addition, some very small subgroups of canine gastric cancer may have different aetiologies. For example few cases of hypertrophic gastritis (Ménétriers‐like disease) progressing into superficial signet‐ring‐type GC are reported . In the Norwegian Lundehunde, atrophic gastritis, characterised by reduction in parietal cells and hyperplasia of neuroendocrine cells, is reported to be associated with gastric tumour development.…”

Hyperplastic and fibrosing gastropathy resembling Ménétrier disease in a cat

“…2,20 A Ménétrier-like disease has been rarely reported in typically older dogs, with the main clinical signs being chronic vomiting and weight loss. 4,6–9 Unusually, the cat presented here was a young adult; however, a transient form of Ménétrier disease has rarely been reported in children, 21,22 and Ménétrier-like disease has been described in young adult dogs. 9 Progressive weight loss and polyphagia were features of this cat’s clinical signs, which are more typical of a malassimilation or malabsorptive state; surprisingly, vomiting was not a significant feature.…”