Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Ahn, Ji Hoon; Cho, Hyunsoo; Kim, Junhee; Kim, Shin Heun; Ham, Je-Seok; Park, Intae; Suh, Sang Heon; Hong, Seon Pyo; Song, Joo‐Hye; Hong, Young‐Kwon; Jeong, Yoong Ki; Park, Sung-Hong; Koh, Gou Young

doi:10.1038/s41586-019-1419-5

Cited by 567 publications

(776 citation statements)

References 28 publications

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“…1,2 Thus, while the brain and spinal cord are bereft of immune cells, conversely, the meninges are the home of a diverse array of immune cells. 8,10,11 The lymphatics of the nasal region were the first to be extensively described, and they have been shown in multiple mammalian species, including humans (rodent, 12-15 larger mammals, 12 primates and humans 12 ). [3][4][5][6] The meninges bear a functional lymphatic system that allows for constant communication between the brain and peripheral immune system, and have been seen to play roles in the development and progression of multiple neurological disorders, such as Alzheimer's and Parkinson's disease.…”

Section: Comple Xit Y Of the Mening E Al Lymphatic Ne T Workmentioning

confidence: 99%

“…11 Contrary to the dorsal meningeal lymphatic network, the basal LV appear to be anatomically more complex. 11 Contrary to the dorsal meningeal lymphatic network, the basal LV appear to be anatomically more complex.…”

Section: Comple Xit Y Of the Mening E Al Lymphatic Ne T Workmentioning

confidence: 99%

“…11 Contrary to the dorsal meningeal lymphatic network, the basal LV appear to be anatomically more complex. 8,11 The presence of a meningeal lymphatic network in non-human primates and humans was confirmed using both magnetic resonance imaging and immunohistochemistry on post-mortem samples. 8,11 The presence of a meningeal lymphatic network in non-human primates and humans was confirmed using both magnetic resonance imaging and immunohistochemistry on post-mortem samples.…”

Section: Comple Xit Y Of the Mening E Al Lymphatic Ne T Workmentioning

confidence: 99%

“…8 Instead of running along veins, they appear to be localized around each nerve root. 11 Studies moving forward will need to analyze the meningeal lymphatic network as a whole and each region separately to fully assess their function and role. 24,25 The different sections of the spinal cord lymphatics will drain into different lymph nodes corresponding to the spinal region: the cervical region appears to drain into the cervical lymph nodes, the thoracic lymphatic into the mediastinal lymph nodes, whereas the lumbar lymphatic drain into the renal and lumbar lymph nodes.…”

Section: Comple Xit Y Of the Mening E Al Lymphatic Ne T Workmentioning

confidence: 99%

“…The LV play many crucial roles, such as maintaining interstitial fluid balance, its endothelium acts as a platform for immune-vascular cross-talk and its tissue-specific self-contractile nature provides LV's luminal surface as a conduit for immune cell trafficking. 11,18 An inflammatory insult could therefore differentially impact the collecting cervical and meningeal lymphatic vessels. Circulation of lymph from the meninges through lymphatics of deep cervical lymph nodes facilitates clearance of brain-derived metabolites and waste products.…”

Section: Impli C Ati On Of the Mening E Al Lymphati C Ne T Work Inmentioning

confidence: 99%

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Meningeal lymphatic network: The middleman of neuroinflammation

Pal

Rao

Louveau

2020

Clinical & Exp Neuroim

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The central nervous system was long thought to be an immune-privileged organ, notably because of its lack of conventional lymphatic drainage. Years of scientific observations and the recent (re)discovery of the meningeal lymphatic system has brought new insights into the relationship of the brain with the peripheral immune system. The extended meningeal lymphatic network has been shown to be a major route for the circulation of molecular and cellular cerebrospinal fluid constituents to the cervical lymph nodes, and participates in the maintenance of brain function and the development of neurological disorders. In this review, we discuss the functional anatomy of the meningeal lymphatic network, its role in neuro-inflammatory and neurodegenerative disorders, and its therapeutic potential.

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Section: Comple Xit Y Of the Mening E Al Lymphatic Ne T Workmentioning

confidence: 99%

Section: Comple Xit Y Of the Mening E Al Lymphatic Ne T Workmentioning

confidence: 99%

Section: Comple Xit Y Of the Mening E Al Lymphatic Ne T Workmentioning

confidence: 99%

Section: Comple Xit Y Of the Mening E Al Lymphatic Ne T Workmentioning

confidence: 99%

Section: Impli C Ati On Of the Mening E Al Lymphati C Ne T Work Inmentioning

confidence: 99%

See 3 more Smart Citations

Meningeal lymphatic network: The middleman of neuroinflammation

Pal

Rao

Louveau

2020

Clinical & Exp Neuroim

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Nervous System

Snyder¹,

Gibson‐Corley²,

Radælli³

2021

Pathology of Genetically Engineered and Other Mutant Mice

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Emerging Brain‐Pathophysiology‐Mimetic Platforms for Studying Neurodegenerative Diseases: Brain Organoids and Brains‐on‐a‐Chip

Bang

Lee

Choi

et al. 2021

Adv Healthcare Materials

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Neurodegenerative diseases are a group of disorders characterized by progressive degeneration of the structural and functional integrity of the central and peripheral nervous systems. Millions of people suffer from degenerative brain diseases worldwide, and the mortality continues to increase every year, causing a growing demand for knowledge of the underlying mechanisms and development of therapeutic targets. Conventional 2D‐based cell culture platforms and animal models cannot fully recapitulate the pathophysiology, and this has limited the capability for estimating drug efficacy. Recently, engineered platforms, including brain organoids and brain‐on‐a‐chip, have emerged. They mimic the physiology of brain tissue and reflect the fundamental pathophysiological signatures of neurodegenerative diseases, such as the accumulation of neurotoxic proteins, structural abnormalities, and functional loss. In this paper, recent advances in brain‐mimetic platforms and their potential for modeling features of neurodegenerative diseases in vitro are reviewed. The development of a physiologically relevant model should help overcome unresolved neurodegenerative diseases.

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Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Cited by 567 publications

References 28 publications

Meningeal lymphatic network: The middleman of neuroinflammation

Meningeal lymphatic network: The middleman of neuroinflammation

Nervous System

Emerging Brain‐Pathophysiology‐Mimetic Platforms for Studying Neurodegenerative Diseases: Brain Organoids and Brains‐on‐a‐Chip

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