Meningeal Melanocytoma Associated with Ipsilateral Nevus of Ota Presenting as Intracerebral Hemorrhage: Case Report

Abstract

The combination of nevus of Ota and meningeal melanocytoma has been reported in only four cases in the literature, including the current case. This is the first case coinciding with intracerebral hemorrhage, suggesting the necessity for careful follow-up with radiological images.

Intracranial meningeal melanocytoma associated with nevus of Ota

“…The association of a meningeal melanocytoma with an ipsilateral nevus of Ota is extremely rare, with only seven patients reported. [1][2][3][4][5][6][7] Here we report a 36-year-old man with a parasellar meningeal melanocytoma associated with a congenital nevus of Ota.…”

“…[1][2][3][4][5] Primary sacral neoplasms are uncommon in comparison to other sites of spine-related neoplasms in adults. Even less common is a chondromyxoid fibroma (CMF) originating from the sacrum.…”

Nevus of Ota”- A Rare Pigmentation Disorder with Intraoral Findings

“…It can also be associated with other cutaneous disorders and ocular disease. Benign cutaneous and leptomeningeal conditions associated with nevus of Ota are phakomatosis pigmentovasculari, nevus flammeus, Sturge-Weber syndrome, Takayasu disease, Klippel-Trenaunay syndrome, and neurofibromatosis [7].…”

“…Sclera and oral mucosa are not involved in acquired bilateral nevus of Ota like macules (ABNOM) or Sun's nevus [7,8].…”

Primary melanocytic neoplasms of the central nervous system

“…[28][29][30][31] Meningeal melanocytomas are mass lesions and present with focal neurological signs associated with their location, intracranial hypertension or haemorrhage, neuropsychiatric symptoms, spinal cord compression, or seizures. 3,25,[32][33][34][35][36][37] They most commonly occur in the cervical and thoracic spine as intradural, extramedullary lesions. The age at diagnosis ranges from 9 to 73 years, with a peak incidence in the fifth decade and a slight female preponderance.…”