Meningioangiomatosis Occurring in a Young Male Without Neurofibromatosis

Takeshima, Yukio; Amatya, Vishwa Jeet; Nakayori, Fumio; Nakano, Tomohiro; Sakamoto, Kazuhiko; Inai, Kei

doi:10.1097/00000478-200201000-00017

Cited by 36 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2,16 The pathognomonic finding of this tumor is its invasive nature, characterized pathologically by invasive meningiovascular proliferation, perivascular cuffs of spindle cell proliferation, perivascular connective tissue proliferation, and neurofibrillary tangles, often interspersed with more discrete meningiomas (3,4,9,10,12,16–21,24,26). …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multifocal meningioangiomatosis in a 3-year-old patient

Jamil¹,

Ramkissoon

Folkerth

et al. 2012

PED

View full text Add to dashboard Cite

Meningioangiomatosis consists of benign hamartomatous lesions of the brain and the leptomeninges, which typically present with seizure. Management is predicated on resection and control of seizures with medication. Lesions are typically solitary. Multifocal meningioangiomatosis is extremely rare, with only 2 cases reported in adults and none in children. The authors report the first case, to their knowledge, of multifocal meningioangiomatosis in a child. This unique case highlights therapeutic challenges associated with these lesions and demonstrates that multifocality is possible in the pediatric population. This finding has implications for diagnosis and follow-up for children afflicted with these tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Sporadic meningioangiomatosis rarely occurs in children younger than 3 years of age. Anatomically, lesions are most frequently identified in the temporal lobe, followed by the frontal, parietal, and occipital lobes in descending order (4,16,21). Clinically, meningioangiomatosis usually presents with seizures and headaches.…”

Section: Discussionmentioning

confidence: 99%

Multifocal meningioangiomatosis in a 3-year-old patient

Jamil¹,

Ramkissoon

Folkerth

et al. 2012

PED

View full text Add to dashboard Cite

show abstract

“…Wiebe et al [1] reported that 43% of patients became seizure-free, and improvements in epilepsy occurred in 30% of cases; furthermore, 20% of cases did not require administration of antiepileptic drugs postoperatively. When surgical treatment failed to obtain favorable outcomes, it was suggested that the epileptic foci were extended to the adjacent cortex or even remote regions [9.] In the present case, an intraoperative electrocorticogram demonstrated epileptic discharges arising from the cortex flanking the hard mass, but not from the lesion itself.…”

Section: Discussionmentioning

confidence: 66%

Cystic Meningioangiomatosis

et al. 2006

View full text Add to dashboard Cite

A case of cerebral meningioangiomatosis with rare cyst formation is reported. A 14-year-old boy without any stigmata of neurofibromatosis type 2 presented intractable complex partial and generalized seizures since the age of 12 years. Neuroradiological studies showed an abnormal cystic mass with calcification in the left frontal lobe of the cerebrum. The tumor was located in the leptomeninges and cerebral cortex. The patient underwent surgical treatment because medical treatment with phenytoin and sodium valproate was not sufficient to control the seizures. An intraoperative electrocorticogram revealed that epileptic foci were recorded from the cortex, which was adjacent to the lesion. Histopathology showed specific features of meningioangiomatosis with meningioma-like nodules. The patient did not have any seizures with anticonvulsants after surgery. It is important to distinguish meningioangiomatosis from other possible cortical lesions and epileptic foci should be carefully considered before resection, because it is a benign and surgically manageable cause of seizures.

show abstract

“…Partial removal of the tumor has been shown to improve symptoms, but total removal still seems to be more effective [8,20]. In patients in whom postoperative seizure control was not successful, extension of the epileptic foci was found to occur with time [21]. In our patient, ECoG revealed perilesional cortical spikes, and epileptogenic foci were present in not only the right temporal lobe but also the right hippocampus.…”

Section: Discussionmentioning

confidence: 76%

Multicystic meningioangiomatosis

Cui

Wang

et al. 2014

BMC Neurol

View full text Add to dashboard Cite

BackgroundMeningioangiomatosis (MA) is a rare hamartomatous lesion. Only six cases of cystic MA have been reported in the literature.Case presentationWe present a case of multicystic MA. A 21-year-old woman without any stigmata of neurofibromatosis type 2 presented with intractable seizures since 10 years. Brain magnetic resonance imaging revealed a well-defined, multicystic mass with heterogeneous signal intensity in the right temporal lobe. The patient underwent resection of the lesion and of the epileptogenic cortex under intraoperative electrocorticography (ECoG) assistance. Histopathological examination showed proliferation of perivascular cells that were arranged in a cuff pattern and were positive for vimentin, D2-40 and smooth muscle actin. Mutiple microcysts and enlarged perivascular spaces were present, which was similar to the structure of the arachnoid cavity. Hyalinized collagen fibers with round concentric acellular eosinophilic lamellae within areas of reactive gliosis were noted for the first time in MA. The patient was followed up without any clinical symptoms or recurrence for 2 years.ConclusionMA may originate from arachnoid and vascular tissue trapped in the cortical parenchyma during brain development, and the cysts may have resulted from the gradual accumulation of cerebrospinal fluid in the perivascular spaces of the trapped tissue. Resection of the lesion and of the epileptogenic cortex is important not only for pathological diagnosis but also for seizure control, and intraoperative ECoG assistance is recommended.

show abstract

Meningioangiomatosis Occurring in a Young Male Without Neurofibromatosis

Cited by 36 publications

References 16 publications

Multifocal meningioangiomatosis in a 3-year-old patient

Multifocal meningioangiomatosis in a 3-year-old patient

Cystic Meningioangiomatosis

Multicystic meningioangiomatosis

Contact Info

Product

Resources

About