Meningiomas: Correlation of Ki67 with histological grade

Babu, Sashidhar; Uppin, Shantveer G; Uppin, Megha S; Panigrahi, Manas; Saradhi, Vijay; Bhattacharjee, Suchanda; Sahu, Barada Prasad; Purohit, A K; Challa, Sundaram

doi:10.4103/0028-3886.79140

Cited by 36 publications

(28 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…b CNPase staining versus Olig2 positive cells/mm2. Sector 1 indicates cases with reactive oligodendroglial hyperplasia and normal myelin content, sector 2 cases with normal myelin and oligodendrocyte numbers and sector 3 burnout of oligodendroglia either with normal myelin levels (3a) or with severe cell and myelin loss (3b).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex

et al. 2017

View full text Add to dashboard Cite

Conventional antiepileptic drugs suppress the excessive firing of neurons during seizures. In drug‐resistant patients, treatment failure indicates an alternative important epileptogenic trigger. Two epilepsy‐associated pathologies show myelin deficiencies in seizure‐related brain regions: Focal Cortical Dysplasia IIB (FCD) and cortical tubers in Tuberous Sclerosis Complex (TSC). Studies uncovering white matter‐pathology mechanisms are therefore urgently needed to gain more insight into epileptogenesis, the propensity to maintain seizures, and their associated comorbidities such as cognitive defects. We analyzed epilepsy surgery specimens of FCD IIB (n = 22), TSC (n = 8), and other malformations of cortical development MCD (n = 12), and compared them to autopsy and biopsy cases (n = 15). The entire lesional pathology was assessed using digital immunohistochemistry, immunofluorescence and western blotting for oligodendroglial lineage, myelin and mTOR markers, and findings were correlated to clinical parameters. White matter pathology with depleted myelin and oligodendroglia were found in 50% of FCD IIB and 62% of TSC cases. Other MCDs had either a normal content or even showed reactive oligodendrolial hyperplasia. Furthermore, myelin deficiency was associated with increased mTOR expression and the lower amount of oligodendroglia was linked with their precursor cells (PDGFRa). The relative duration of epilepsy (normalized to age) also correlated positively to mTOR activation and negatively to myelination. Decreased content of oligodendroglia and missing precursor cells indicated insufficient oligodendroglial development, probably mediated by mTOR, which may ultimately lead to severe myelin loss. In terms of disease management, an early and targeted treatment could restore normal myelin development and, therefore, alter seizure threshold and improve cognitive outcome.

show abstract

Section: Resultsmentioning

confidence: 99%

“…For determination of oligodendroglial proliferation (Ki67 and Olig2/Ki67) at least 100 nuclei were counted at high magnification (400×) and the average number of (double) positive cells was expressed as percentage 1.…”

Section: Methodsmentioning

confidence: 99%

Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex

et al. 2017

View full text Add to dashboard Cite

show abstract

“…[2] Transitional meningiomas are the most common subtype with an incidence of 48% (Table 1) whereas the study by Sanghamithra et al [11] showed meningothelialmeningiomas as the most frequent type of occurrence. According to Sameh Ahmed et al [12] and SashidharBabu et al [13] , grade III meningiomas showed the least rate of occurrence. In contrast our study showed grade II to be the least common type (4%).…”

Section: Discussonmentioning

confidence: 99%

Histopathological Analysis and Correlation of Ki67 and Progesterone Receptor Status with WHO Grading In Meningiomas

Veeramani

Maheswari²

2017

APALM

View full text Add to dashboard Cite

Background: Meningiomas are slow growing tumors that are among the most common of CNS neoplasms and form the most common CNS tumor to be reported above 35 years of age.Methods: This retrospective study was carried out in the Department of Pathology during the period of January2011 to May2013. A total of 50 cases were graded according to the WHO 2016 grading criteria. The biopsy specimens were fixed in 10% neutral buffered formalin, sections was stained with Hematoxylin & Eosin. Immunohistochemistry was done with Progesterone receptor and Ki67 antibodies for selected cases.Results: The incidence of meningiomas was 33.11% with a female sex predilection and most common in the 5th decade. Transitional meningioma was the most common variant to occur. The incidence of WHO Grade I, Grade II and Grade III meningiomas were 88%, 4% and 8% respectively. Comparison of Ki67 LI and PR score in various grades of meningiomas were done. The average Ki67 LI and PR score were 1.1%, 10.25; 6%, 3; 16%, 0 in grade I, II and III meningiomas respectively. p value showed a statistically significant difference between different grades of meningiomas with respect to PR and Ki67 status. Spearman correlation showed a clearly significant inverse relationship between the two antibodies. Conclusion:The use of immunohistochemical markers aids in determining the aggressive nature of the tumor, its recurrence potential and can be used as prognostic markers.

show abstract

“…In all the reference studies Grade I tumors were more common. Higher incidence of Grade II tumors was noted in the studies done by S Babu et al (26%) [41] and Grondahl TB et al (30.1%) [24]. Grade III tumors were less common in all the studies.…”

Section: Discussionmentioning

confidence: 71%

Clinicopathological study of Meningioma

Jansari

Patel

Chaudhari³

2020

Trop J Pathol Microbiol

View full text Add to dashboard Cite

Introduction: Meningiomas are tumors that arise from the meningothelial cells. They are commonly located at intracranial, intraspinal or occasionally ectopic site. They show histological diversity and are categorized into three grades. This grading helps in predicting their behaviour and deciding treatment strategy. Aims and Objectives: To study the incidence, anatomical location, sex and age Predilection, histological variants and grading of meningiomas based on WHO 2016 classification. To correlate clinical features and radiological findings with those of histopathological findings. Materials and Methods: The study is carried out in the Department of Pathology, Dhiraj General Hospital, Piparia from November 2016 to July 2018. 30 tumors specimen diagnosed as meningioma by radiology and neurosurgery department, sent to department of pathology were included in the study. Analysis of histological features, typing and grading of all cases was done according to WHO 2016 classification of meningioma. Results: Total 30 meningioma tumors were included in the study. Most of them were intracranial, predominantly involving the posterior fossa of brain, females and the 41-60 age group. The most common histological subtype was psammomatous followed by meningothelial. Majority (93.33%) were benign grade I tumors. In 90% cases radiological diagnosis matched exactly with histopathological diagnosis. Conclusion: Meningiomas are slow growing tumors arising from the meningothelial cells accounting for 15-30 % of all CNS neoplasms showing a variety of histological patterns, more common in women, predominantly Grade I tumors. Recurrence of tumors depends on histological grade and extent of surgery.

show abstract

Meningiomas: Correlation of Ki67 with histological grade

Abstract: High Ki67 LI indicates higher grade of meningioma. The difference in KI67 LI between recurrent and non-recurrent meningiomas was statistically significant.

Cited by 36 publications

References 9 publications

Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex

Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex

Histopathological Analysis and Correlation of Ki67 and Progesterone Receptor Status with WHO Grading In Meningiomas

Clinicopathological study of Meningioma

Contact Info

Product

Resources

About