Meningiomas with conspicuous plasma cell-lymphocytic components.A report of five cases

Horten, Bruce; Urich, H.; Stefoski, Dusan

doi:10.1002/1097-0142(197901)43:1<258::aid-cncr2820430137>3.0.co;2-9

Cited by 89 publications

(32 citation statements)

References 10 publications

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“…Lymphoplasmacytic meningioma elicits a pronounced chronic inflammatory reaction, which may be confused with the infiltrates of RDD-CNS (27). Recognition of typical meningioma histology coupled with confirmatory immunostaining for epithelial membrane antigen readily differentiates these two processes.…”

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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Sinus histocytosis with massive lymphadenopathy, also known as Rosai-Dorfman Disease (RDD), is an idiopathic histiocytic proliferation affecting lymph nodes. Although extranodal involvement has been reported in diverse sites, central nervous system (CNS) manifestation, particularly in the absence of nodal disease is uncommon. We report 11 cases of RDD primary to the CNS without evidence of other sites of involvement. The cases included 7 males and 4 females ranging in age from 22 to 63 years (mean: 41 y). The patients presented with headaches, seizures, numbness, or paraplegia. Eight cases involved the cranial cavity and three cases, the spinal canal. Lesions were most often extra-axial and dura based. Only one presented in the CNS parenchyma. Histologically, the lesions consisted of variable numbers of pale-staining histocytes with emperipolesis often overshadowed by extensive lymphoplasmacytic infiltrates and fibrosis in the background. Special stains for organisms were negative. By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein and CD68 and negative for CD1a. Treatment consisted of surgical biopsy or excision. Follow-up, available for 10 cases with intervals ranging from 5 days to 42 months (mean: 15 mo), disclosed one patient dying of operative complications 5 days after biopsy and nine patients with no evidence of disease progression RDD should be considered in the differential diagnosis of inflammatory lesions of the CNS. Our study suggests that this entity may have been misdiagnosed in the past as plasma cell granuloma or inflammatory pseudotumor.

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Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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“…The proportions of inflammatory and meningothelial components varied from case to case; some might have been true meningioma with a striking inflammatory component [11,20], other were inflammatory masses with nests of trapped hyperplastic meningothelial cells. In all cases, inflammation was not accounted for by an infectious agent, a malignancy or a recognized systemic disorder.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature

Deprez

Born

Hauwaert

et al. 1997

Acta Neuropathologica

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A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were suggestive of multiple meningeal neoplasms and a correct diagnosis was made only after meningeal biopsy. This 44-yearold patient had a previous history of an ill-defined systemic disorder associating episcleritis, erythroderma nodosa and multiple peripheral arthritis. We review previous reports of idiopathic cranial pachymeningitis with emphasis on radiological investigation techniques, histopathology and possible dysimmune mechanisms of pathogenesis.

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“…Inflammatory meningiomas, of which few examples have been documented, contain plasma cell-lymphocytic components [lymphocyte-rich meningioma (LRM)], which were absent in our patient (4). Radiation treatment of tumors may cause necrosis with attendant inflammation.…”

Section: Discussionmentioning

confidence: 70%

Clinical Without Histopathological Manifestations of Inflammation in a Patient With Primary Intraorbital Optic Nerve Sheath Meningioma

Lessell

Kim

Hatton

et al. 2007

Journal of Neuro-Ophthalmology

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A 28-year-old man with a biopsy-proven benign intraorbital optic nerve sheath meningioma developed recurrent clinical manifestations of ipsilateral retrobulbar inflammation 9 years after undergoing postoperative radiation therapy. Debulking of the tumor 11 years after the original surgery again revealed no pathologic signs of inflammation. Whether growth of tumor, surgery, radiation, or edema triggered the inflammatory manifestations is unclear. Our case affirms that primary optic nerve meningiomas may rarely cause episodic manifestations resembling those of idiopathic orbital inflammation that resolve with corticosteroid treatment.

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Meningiomas with conspicuous plasma cell-lymphocytic components.A report of five cases

Abstract: Five meningeal neoplasms grossly resembling meningiomas but histologically containing meningothelial cells together with abundant plasma cells and lymphocytes are reported. These masses are regarded as meningiomas with extensive plasma cell--lymphocytic infiltrates.

Cited by 89 publications

References 10 publications

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Idiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature

Clinical Without Histopathological Manifestations of Inflammation in a Patient With Primary Intraorbital Optic Nerve Sheath Meningioma

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