Meningiomas with different histological grade in the same patient

Liu, Yang; Song, Da-Ping; Wang, Tong

doi:10.1097/md.0000000000009086

Cited by 8 publications

(13 citation statements)

References 18 publications

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“…Koh et al12 reported a case of MMs with both malignant and benign histological features and proposed MMs originated from multicentric neoplastic foci. Similarly, Liu et al11 showed the coexistence of fibrous meningioma (WHO grade I) and atypical meningioma (WHO grade II) in the same patient. More recently, Tsermoulas et al29 reviewed a total of 133 consecutive patients with MMs for over 25 years and 18 patients had surgical removal of more than one meningioma.…”

Section: Discussionmentioning

confidence: 67%

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<p>Whole exome sequencing of multiple meningiomas with varying histopathological presentation in one patient revealed distinctive somatic mutation burden and independent clonal origins</p>

Huang¹,

Shen²,

Zhang³

et al. 2019

CMAR

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Background: Although meningiomas are common intracranial tumors, multiple meningiomas (MMs) are rare entities in patients without neuroﬁbromatosis type 2. Previous studies suggest most sporadic MMs are of monoclone in origin. Objective: To elucidate the clonal relationship between two sporadic meningiomas from the same patient by using the next-generation sequencing (NGS) platform. Methods: Two MMs, located frontally and parietally on the right side, were surgically removed from a 52-year-old male. Pathological examinations and whole exome sequencing were performed on tumor samples, followed by Sanger sequencing validation. Results: MMs were diagnosed as secretory and fibrous subtypes, respectively, on histology (WHO grade I) and tumor DNA exhibited distinctive somatic mutation patterns. Specifically, the secretory subtype carried more single nucleotide variant while the fibrous subtype had much higher copy number variation. Besides, the two tumors demonstrated different mutation profiles in predisposing genes and known driver mutations. For example, the secretory subtype had missense mutations in TRAF7 and KLF4 , while the fibrous subtype had frameshift deletion of NF2 gene in addition to copy number loss of NF2 and SMARCB1 , genetic events that have already been associated with the development of meningiomas. Significantly mutated gene analysis revealed novel mutations of LOC729159 in the secretory subtype and RPGRIP1L and DPP6 in the fibrous subtype. Sanger sequencing validated important point mutations in TRAF7 (c.1678G>A, p .G560S), KLF4 (c.1225A>C, p .K409Q) and CDH11 (c.169T>G, p .W57G). Conclusion: Our data suggest the two meningiomas might develop independently in this patient and molecular subtyping by NGS is a valuable supplement to conventional pathology. Further study is needed to ascertain whether these novel genetic events are tumorigenic or simply passenger mutations, as well as their clinical implications

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Section: Discussionmentioning

confidence: 67%

“…However, the incidence of sporadic MMs in patients without a history of NF2 is low 10. It is much less common to find these sporadic MMs bearing different histological features in the same patient 11. The etiology of MM is still being debated because of two hypotheses for the development of MMs, ie, monoclonal or independent 12.…”

Section: Introductionmentioning

confidence: 99%

<p>Whole exome sequencing of multiple meningiomas with varying histopathological presentation in one patient revealed distinctive somatic mutation burden and independent clonal origins</p>

Huang¹,

Shen²,

Zhang³

et al. 2019

CMAR

View full text Add to dashboard Cite

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“…The incidence of meningioma is apparently rising not only due to improved and extensive neuroimaging but also due to increased proportion of the elderly population where it has the common occurrence [10]. The higher incidence of meningioma in adult females reported in recent literature in contrast to previous reports of male preponderance is highly attributed to various reproductive and hormonal factors [11].…”

Section: Discussionmentioning

confidence: 97%

“…Arachnoid cap cells are the usual sites for origin of most meningiomas with majority being benign. Less percentage of meningioma show signs of malignancy like marked vascularity; lack of internal organoid architecture; higher percentage of mitotic figures, nuclear pleomorphism; disproportionately large nucleolus, focal necrosis and infiltration in to brain parenchyma along with variable expression of Ki-67, a marker for tumor recurrence in atypical and anaplastic meningiomas [10,12,13].…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Dural and Intraventricular Meningioma-A Rare Entity

Rastogi

Gupta

Pathak

et al. 2020

OJNBD

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Meningioma is a commonly encountered solitary, benign, intracranial, extra-axial tumor in day-to-day brain imaging. Majority are dural-based located commonly at the cerebral convexities. Uncommonly, they are multiple or may be seen in intraventricular location. Coexisting dural and intraventricular meningioma is an exceedingly rare entity. It may be difficult to differentiate them from metastases. Hence through this case report, we attempt to describe this rare entity with its differentiation from similarappearing lesions.

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“…A widely accepted hypothesis for multiple meningiomas is spread of clones of neoplastic cells through cerebrospinal fluid as well as hematogenous spread [3]. Different etiological factors were considered in the development of meningiomas, one of which is deletion of chromosome 22 in patients with type II neurofibromatosis.…”

Section: Discussionmentioning

confidence: 99%

Multiple Intracranial Meningiomas - A Case Report

Patil¹,

Mayekar²,

Nasre³

2020

SJAMS

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Case Report Meningiomas are benign tumors, accounting for 13-20% of all primary central nervous systems tumors. Multiple meningiomas are rare and the term is used for more than one meningioma occurring in several intracranial locations without signs of neurofibromatosis. The prognosis of multiple intracranial meningiomas is similar to benign solitary meningioma. We present a rare case of multiple intracranial meningiomas in a 45 years old female patient.

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Meningiomas with different histological grade in the same patient

Cited by 8 publications

References 18 publications

<p>Whole exome sequencing of multiple meningiomas with varying histopathological presentation in one patient revealed distinctive somatic mutation burden and independent clonal origins</p>

<p>Whole exome sequencing of multiple meningiomas with varying histopathological presentation in one patient revealed distinctive somatic mutation burden and independent clonal origins</p>

Coexistence of Dural and Intraventricular Meningioma-A Rare Entity

Multiple Intracranial Meningiomas - A Case Report

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