Meningite pneumocócica na infância: características clínicas, sorotipos mais prevalentes e prognóstico

Berezin, Eitan N.; Carvalho, Luiza H.; Lopes, Carla; Sanajotta, Andréia T.; Brandileone, Maria Cristina C.; Menegatti, Sonia; Sáfadi, Marco Aurélio Palazzi; Guerra, Maria Luiza C.S.

doi:10.1590/s0021-75572002000100006

Cited by 19 publications

(36 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8,4,[10][11][12] Of this study, seven (54%) of the 13 children less than 2 years old had suffered IPD due to SpNSPn. It is possible that this high level of penicillin resistance is partially due to the fact that HIV+ patients are often given antimicrobial treatment.…”

Section: %mentioning

confidence: 72%

“…The majority of these refer to colonization of the airways by Sp, since the difficulties in isolating the bacteria from cultures from people with pneumonia are well known. 4,[9][10][11][12][13] The only study published in Brazil on Sp serotypes identified from HIV+ children demonstrated that nasopharyngeal colonization of 112 children was no greater than that described in the literature for healthy children. 3 In our study, serotype 14 was the most frequent (four cases) and was also the serotype that exhibited greatest resistance to penicillin, which confirms data published in Brazilian literature.…”

Section: Resultsmentioning

confidence: 93%

“…Invasive pneumococcal disease (IPD) primarily affects children less than 5 years old, the elderly and certain other risk groups, among whom those infected by the human immunodeficiency virus (HIV+) are prominent. [1][2][3][4] The risk of HIV+ patients developing pneumonia is 10 to 100 times greater than for the uninfected. 1 In Brazil, although HIV infection is one of the primary risk factors for IPD, studies of IPD in this group of patients remain scarce.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Doença pneumocócica invasiva em crianças e adolescentes soropositivos para HIV

Mattei¹,

Falleiros-Carvalho²,

Cavalcante³

2008

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objective: Invasive pneumococcal disease (IPD) primarily affects children less than 5 years old, the elderly and certain at-risk groups; especially people infected by the human immunodeficiency virus (HIV). The objective of this study was to analyze invasive pneumococcal diseases (IPD) in children and adolescents infected by the human immunodeficiency virus (HIV), with relation to morbidity, the case fatality ratio, pneumococcus serotypes, susceptibility to penicillin and ceftriaxone and to the proportion of susceptible and resistant Streptococcus pneumoniae (Sp) included in the 7-valent pneumococcal conjugate vaccine that has already been licensed. Methods:A total of 19 cases of IPD were identified among HIV seropositive patients aged from 1 month to 20 years and hospitalized between 1993 and 2000. Data were recorded on standardized charts containing information on age, clinical diagnosis and progression, serotypes and the susceptibility to penicillin and ceftriaxone of the Sp strains identified in cultures. When the minimum inhibitory concentration was < 0.1 mcg/mL, Sp were defined as susceptible to penicillin (SpSPn), and all other strains were defined as not susceptible (SpNSPn). Results:Of the 19 HIV seropositive cases with IPD, 16 (84%) had pneumonia and three (16%), had meningitis; 13 (68%) cases were children less than 2 years old and 16 (84%) were less than 5 years old. The case fatality ratio was 10%. Seven (54%) of the 13 cases less than 2 years old were SpNSPn and 10 (77%) were caused by serotypes covered by the 7-valent pneumococcal conjugate vaccine. From the 10 isolated serotypes the most frequent were 14, 6B and 23F, all them susceptible to ceftriaxone. From the three patients with meningitis, two were caused by SpNSPn. Conclusion:In this study most of the IPD occurred in children less than 2 years old; 77% of the strains and 86% of the serotypes of SpNSPn were covered by the 7-valent pneumococcal conjugate vaccine.J Pediatr (Rio J). 2008;84(3):276-280: Pneumococcus, Streptococcus pneumoniae, children, adolescents, HIV seropositive, meningitis, pneumonia, invasive pneumococcal disease, antipneumococcal vaccine.

show abstract

Section: %mentioning

confidence: 72%

Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Doença pneumocócica invasiva em crianças e adolescentes soropositivos para HIV

Mattei¹,

Falleiros-Carvalho²,

Cavalcante³

2008

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

show abstract

“…[1][2][3] In spite of pneumonias causing the largest number of deaths, the mucosal diseases caused by pneumococcus are more common, and the use of antibiotics to treat otitis and sinusitis have been associated with the appearance and dissemination of antibiotic resistant strains. [4][5][6][7] Pneumococcal diseases are more common in children younger than 2 years, elderly people, and in certain groups of individuals that present conditions associated with the development of invasive pneumococcal diseases (IPD) ( Table 2). [1][2][3][4][5][6][7][8][9][10][11][12] Moreover, they affect poorer populations more seriously, aggravating the situation of these populations even further.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7] Pneumococcal diseases are more common in children younger than 2 years, elderly people, and in certain groups of individuals that present conditions associated with the development of invasive pneumococcal diseases (IPD) ( Table 2). [1][2][3][4][5][6][7][8][9][10][11][12] Moreover, they affect poorer populations more seriously, aggravating the situation of these populations even further. 1,4 In Brazil, the highest rate of incidence of pneumococcal meningitis has been registered in nursing infants younger than 1 year, and bacterial resistance has increased progressively.…”

Section: Introductionmentioning

confidence: 99%

Impacto da vacina conjugada contra Streptococcus pneumoniae em doenças invasivas

Bricks¹,

Berezin²

2006

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

. Articles retrieved with the keywords Streptococcus pneumoniae, pneumococcal diseases, conjugate vaccine, antimicrobial resistance and meningitis were reviewed. Summary of the findings:The introduction of heptavalent pneumococcal conjugate vaccine caused a dramatic reduction in the incidence of invasive pneumococcal diseases in American children, reduced antibiotic use and the number of medical visits due to otitis media and pneumonia by children. The incidence of invasive pneumococcal diseases caused by resistant strains declined in immunized children, adults and elderly individuals. In Brazil, the mortality rate of pneumococcal meningitis is very high and the resistance to antibiotics has increased over the last 5 years.Conclusions: Heptavalent pneumococcal conjugate vaccine can benefit not only children, but the entire community and should be included in the Brazilian routine immunization schedule.J Pediatr (Rio J). 2006;82(3 Suppl):S67-74: Streptococcus pneumoniae, pneumococcal disease, conjugate vaccines, pneumonia, meningitis, antimicrobial resistance.

show abstract

Cost-effectiveness of introducing the 10-valent pneumococcal conjugate vaccine into the universal immunisation of infants in Brazil

Sartori¹,

Novaes

2010

J Epidemiol Community Health

View full text Add to dashboard Cite

show abstract

Meningite pneumocócica na infância: características clínicas, sorotipos mais prevalentes e prognóstico

Abstract: These findings suggest that pneumococcal meningitis presents high mortality and morbidity and that the 7-valent conjugate vaccine would be potentially useful in preventing serious pneumococcal infections.

Cited by 19 publications

References 15 publications

Doença pneumocócica invasiva em crianças e adolescentes soropositivos para HIV

Doença pneumocócica invasiva em crianças e adolescentes soropositivos para HIV

Impacto da vacina conjugada contra Streptococcus pneumoniae em doenças invasivas

Cost-effectiveness of introducing the 10-valent pneumococcal conjugate vaccine into the universal immunisation of infants in Brazil

Contact Info

Product

Resources

About