Meningitis and Encephalitis Associated with Mumps Infection: A 10-Year Survey

Johnstone, Julie; Ross, Constance A. C.; Dunn, Margaret H.

doi:10.1136/adc.47.254.647

Cited by 66 publications

(16 citation statements)

References 7 publications

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“…It is not known the rationale for predominance in male 11 , which ratios are greater than most infectious diseases in childhood 12 and this is in accordance to literature data 6,8 , ranging from 2.4 2,14 to 6 21 for 1. In this study this ratio was 3:1.…”

Section: Discussionsupporting

confidence: 79%

“…In this study this ratio was 3:1. Since mumps incidence is equal for both sexes 10,19 , meningoencephalitis probably is related to differences in clinical features suggested by the following reasons: a) female children shows more subclinical infections 11 ; b) there is a possibility of occurrence of parotiditis and pleocytosis with no sign of meningeal involvement 3 ; c) it is possible that children with greater sensibility to painful symptoms reports well what they feel 17 ; and d) boys complaints more because they expressed more externalizing symptoms, are likely to tolerate pain less and are less resilient than girls 15 . We believe that these findings could explain this occurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Related to age groups several researchers have found the range 5-9 years the more susceptible 11,14,18 , probably because it is the range which has the greater incidence of mumps 27 and children begin to socialize and agglomerate during school activities.…”

Section: Discussionmentioning

confidence: 99%

“…Etiologic diagnosis is suspected when parotiditis is associated and this was manifested until 3 weeks before acute neurologic period. Parotiditis is accepted as an important criterion 11,18 and differential diagnosis must be considered in the absence of epidemiological data or when it is atypical 16 . It is the purpose of this report discuss some epidemiologic findings which were observed in a definite population, during the course of meningoencephalitis caused by mumps virus (MEMV) in children related to sex, age and seasonal influences.…”

mentioning

confidence: 99%

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Mumps meningoencephalitis: an epidemiological approach

Leboreiro-Fernandez

Moura-Ribeiro

Leboreiro

et al. 1997

Arq. Neuro-Psiquiatr.

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-The aim of this study was to analyse distribution of meningoencefalitis caused by mumps viras in children related to sex, age and seasonal influences. Thirty seven children were evaluated, ages ranging from 2 to 14 years. They were seen at Emergency Unit of Faculdade de Medicina do Triângulo Mineiro and at Hospital da Criança, in Uberaba-MG, Brazil, from March 1st 1991 to February 1st 1993 and they were hospitalized for about 5 days. Through a protocol findings were studied during hospitalization and clinical course stressing epidemiology, symptomatology, cerebrospinal fluid studies, electroencephalogram and cortical function analysis. Only epidemiological data were considered in the present study. Data analysis revealed male predominance, at a range from 5 to 9 years and great number of occurrences at the last quarter of the year.KEY WORDS: mumps meningoencephalitis, neuroepidemiology, aseptic meningoencephalitis. Meningoencefalite pelo vírus da caxumba: abordagem epidemiológicaRESUMO -O presente trabalho tem por objetivo, estudar a distribuição quanto ao sexo, idade e sazonalidade, em crianças com meningencefalite pelo vírus da caxumba. Foram avaliadas 37 crianças, com idades variando de 2 a 14 anos, atendidas no Pronto-Socorro do Hospital Escola da FMTM e do Hospital da Criança, MG, no período de 1-março-1991 a 1-fevereiro-1993 e hospitalizadas por período médio de 5 dias. Através de protocolo pré-elaborado foram estudados os achados obtidos por ocasião da internação e evolução, enfatizando-se a epidemiologia, sintomatologia, líquido cefalorraqueano, eletrencefalograma e função cortical. São considerados apenas os dados epidemiológicos, no presente estudo. A análise das informações pertinentes revela predomínio no sexo masculino, na faixa etária dos 5 aos 9 anos e maior número de casos no último trimestre do ano, correspondente à estação da primavera.PALAVRAS-CHAVE: meningencefalite pelo vírus da caxumba, neuroepidemiologia, meningencefalite asséptica.Mumps virus is one of the most frequent agents causing aseptic meningoencephalitis in patients under 15 years old. Nevertheless, the real incidence is clinically difficult to establish because it occurs asymptomatically (36%) 3 or in the absence of parotiditis (29%) 26 . Cerebrospinal fluid (CSF) studies in patients with epidemic parotiditis show pleocytosis ranging from 34% (26/77) 4 to 63% (235/371) 3 . Mumps virus belongs to genus Paramyxovirus, family Paramyxoviridae, and possess one RNA molecule. Two surface glucoproteins (HN and F) were described, which are essential for Este estudo faz parte da Dissertação de Mestrado do primeiro autor, apresentada à

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Mumps meningoencephalitis: an epidemiological approach

Leboreiro-Fernandez

Moura-Ribeiro

Leboreiro

et al. 1997

Arq. Neuro-Psiquiatr.

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“…Complications include meningitis, encephalitis, and meningoencephalitis. In the absence of parotitis, the meningoencephalitis is clinically indistinguishable from enteroviral infection (70).…”

Section: Enterovirusesmentioning

confidence: 94%

Role of the virology laboratory in diagnosis and management of patients with central nervous system disease

1989

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A number of viruses cause acute central nervous system disease. The two major clinical presentations are aseptic meningitis and the less common meningoencephalitis. Clinical virology laboratories are now more widely available than a decade ago; they can be operated on a modest scale and can be tailored to the needs of the patients they serve. Most laboratories can provide diagnostic information on diseases caused by enteroviruses, herpesviruses, and human immunodeficiency virus. Antiviral therapy for herpes simplex virus is now available. By providing a rapid diagnostic test or isolation of the virus or both, the virology laboratory plays a direct role in guiding antiviral therapy for patients with herpes simplex encephalitis. Although there is no specific drug available for enteroviruses, attention needs to be paid to these viruses since they are the most common cause of nonbacterial meningitis and the most common pathogens causing hospitalization for suspected sepsis in young infants in the United States during the warm months of the year. When the virology laboratory maximizes the speed of viral detection or isolation, it can make a significant impact on management of these patients. Early viral diagnosis benefits patients with enteroviral meningitis, most of whom are hospitalized and treated for bacterial sepsis or meningitis or both; these patients have the advantage of early withdrawal of antibiotics and intravenous therapy, early hospital discharge, and avoidance of the risks and costs of unnecessary tests and treatment. Enteroviral infection in young infants also is a risk factor for possible long-term sequelae. For compromised patients, the diagnostic information helps in selecting specific immunoglobulin therapy. Good communication between the physician and the laboratory will result in the most benefit to patients with central nervous system viral infection.

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Mumps meningoencephalitis. Prolonged abnormality of cerebrospinal fluid

Azimi¹

1975

JAMA: The Journal of the American Medical Association

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Meningitis and Encephalitis Associated with Mumps Infection: A 10-Year Survey

Cited by 66 publications

References 7 publications

Mumps meningoencephalitis: an epidemiological approach

Mumps meningoencephalitis: an epidemiological approach

Role of the virology laboratory in diagnosis and management of patients with central nervous system disease

Mumps meningoencephalitis. Prolonged abnormality of cerebrospinal fluid

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