Meningitis tuberculosa: revisión de 27 años

Jiménez, A Jordán; García, Alfredo Tagarro; Baquero-Artigao, Fernando; Martín, F. del Castillo; Andres, Camilo; Romero, María; Miguel, M. J. García

doi:10.1157/13071835

Cited by 13 publications

(5 citation statements)

References 25 publications

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“…Similarly, a long term mortality study on meningitis TB patients in Denmark, from 1972 to 2008, reported that patients aged between 16 and 60 years had a 2.68 times increased risk of death compared to children [14]. The observed 14% CFR in children is higher than those described by hospital-based studies in Spain (11%; N=28) and Argentina (7%; N=40) [17,18]. However, case inclusion criteria in those studies might have differed from surveillance data and case numbers were small.…”

Section: Discussionmentioning

confidence: 83%

“…Some EPTB forms, such as meningitis cause severe disease. Reported case fatality ranges from 20 to 69% [14] in different settings worldwide with up to half of surviving patients presenting with irreversible sequelae, including paraplegia, blindness, motor and cognitive deficits [15][16][17][18][19]. Prognosis is largely influenced by early diagnosis and adequate treatment [4,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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The burden of extrapulmonary and meningitis tuberculosis: an investigation of national surveillance data, Germany, 2002 to 2009

et al. 2013

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

The burden of extrapulmonary and meningitis tuberculosis: an investigation of national surveillance data, Germany, 2002 to 2009

et al. 2013

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“…TB meningitis is the most severe and life-threatening form of the disease in infants (29). Prompt diagnosis and treatment is essential to the improvement in prognosis of the disease by decreasing the case fatality rate (CFR) and the incidence of irreversible complications (30). The main risk factors for an unfavorable prognosis, including death, are a low Glasgow Coma Scale value at diagnosis, and age under 2 (30).…”

Section: Discussionmentioning

confidence: 99%

“…Prompt diagnosis and treatment is essential to the improvement in prognosis of the disease by decreasing the case fatality rate (CFR) and the incidence of irreversible complications (30). The main risk factors for an unfavorable prognosis, including death, are a low Glasgow Coma Scale value at diagnosis, and age under 2 (30). Ten percent of our children had TB meningitis, much lower than in the under 3-year-old age-group of the largest cohort of culture-confirmed childhood TB from South Africa (14).…”

Section: Discussionmentioning

confidence: 99%

Clinical Presentations and Outcomes Related to Tuberculosis in Children Younger Than 2 Years of Age in Catalonia

et al. 2019

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Introduction: Children younger than 2 years have an increased risk of complications associated with tuberculosis (TB) due to the immaturity of the innate and adaptive immune response. We aimed to identify TB clinical presentations and outcomes as well as risk factors for complications in this age group. Materials and Methods: Multicenter, retrospective, cross-sectional study of TB cases in children aged <2 years in Catalonia (2005–2013). Epidemiological and clinical data were collected from the hospital medical records. TB complications, sequelae included, were defined as any tissue damage generating functional or anatomical impairment after being diagnosed or after TB treatment being completed. Statistical analyses were based on bivariate chi-square and multivariate logistic regression, and it was carried out with Stata® version 13.1. Odds ratios (OR) and its 95% confidence intervals were calculated (CI). Results: A total of 134 patients were included, 50.7% were male, the median [IQR] age was 13[8-18] months, and 18.7% (25/134) showed TB-associated complications. Pulmonary TB was diagnosed in 94.0% (126/134) of children, and the most common complications were lobar collapse (6/126). TB meningitis was diagnosed in 14/134 (10.4%), and hydrocephalus and mental impairment occurred in 1 and 2 patients, respectively. Two patients with spinal TB developed vertebral destruction and paraplegia, respectively. Only one of the patients died. At multivariate level, tachypnea (OR = 4.24; 95% CI 1.17–15.35) and meningeal (OR = 52.21; 95% CI 10.05–271.2) or combined/extrapulmonary forms (OR = 11.3; 95% CI 2.85–45.1) were associated with the development of TB complications. Discussion: TB complications are common in children under 2 years old. Extrapulmonary TB forms in this pediatric age remain a challenge and require prompt diagnosis and treatment in order to prevent them. The presence of tachypnea at the time of TB diagnosis is an independent associated factor to the development of TB complications in infants. This clinical sign should be closely monitored in patients in this age group. It is necessary to perform further studies in this age group in a prospective design in order to understand whether there are other factors associated to TB complications.

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“…Meningeal tuberculosis (MTB) is considered the most devastating manifestation of the disease [8, 9] with a mortality of up to 30% and a high percentage of neurological sequelae in survivors.…”

Section: Introductionmentioning

confidence: 99%

Morbidity Trends and Risk of Tuberculosis: Mexico 2007–2017

Bello–López

León-García

Rojas-Bernabé

et al. 2019

Canadian Respiratory Journal

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Background. To know the current status of the epidemiological and geographic distribution of tuberculosis and its complication meningeal tuberculosis in Mexico, this work analyzes national surveillance data (ten years) issued by the General Directorate of Epidemiology (GDE). Methods. An observational and retrospective analysis of monthly and annual reports of pulmonary and meningeal tuberculosis cases from January 2007 to December 2017 was performed on the annual reports issued by the GDE in Mexico. The number of cases and incidence were classified by year, state, age group, gender, and seasons. Results. A national case distribution map of pulmonary and meningeal tuberculosis incidence was generated. During this period, a total of 184,003 and 3,388 cases were reported with a median of 16,727.5 and 308 cases per year for pulmonary and meningeal tuberculosis diseases, respectively. The number of cases and incidence of pulmonary and meningeal tuberculosis per year showed that male gender presented a continuous increase in both parameters. The geographic analysis of the distribution of cases of tuberculosis showed that states like Guerrero, Tabasco, and Veracruz presented higher means of tuberculosis cases during this period. Northern states had the highest number of cases in the country compared to other states. In Mexico, pulmonary tuberculosis and meningeal tuberculosis are seasonal. Interestingly, cases of meningeal tuberculosis show an increase during October and November (autumn). Conclusions. In Mexico, during the years 2007–2017, there has been an increase in the proportion of male TB patients. It remains necessary to implement strategies to detect TB in the adult population, especially among men, because tuberculosis could be difficult to recognize in an early stage in the population, and the appearance of resistant strains can cause an increase in the incidence of the disease.

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Meningitis tuberculosa: revisión de 27 años

Cited by 13 publications

References 25 publications

The burden of extrapulmonary and meningitis tuberculosis: an investigation of national surveillance data, Germany, 2002 to 2009

The burden of extrapulmonary and meningitis tuberculosis: an investigation of national surveillance data, Germany, 2002 to 2009

Clinical Presentations and Outcomes Related to Tuberculosis in Children Younger Than 2 Years of Age in Catalonia

Morbidity Trends and Risk of Tuberculosis: Mexico 2007–2017

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