Meningococcal Disease Presenting as Bronchiolitis

Hameed, Raghdah Maytham; Riordan, F. A. I.

doi:10.1053/jinf.2001.0956

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…A difficult initial challenge faced by clinicians is distinguishing meningococcal disease in the adolescent patient from more common, self-limited, less virulent infections with similar presentations [6,7]. As illustrated in the case study (appearing elsewhere in this supplement), initial symptoms of meningococcal disease often are nonspecific [4,[8][9][10].…”

Section: Clinical Aspects Of Meningococcal Diseasementioning

confidence: 99%

Meningococcal Disease Awareness: Clinical and Epidemiological Factors Affecting Prevention and Management in Adolescents

Pelton

2010

Journal of Adolescent Health

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Section: Clinical Aspects Of Meningococcal Diseasementioning

confidence: 99%

Meningococcal Disease Awareness: Clinical and Epidemiological Factors Affecting Prevention and Management in Adolescents

Pelton

2010

Journal of Adolescent Health

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“…According to the case reports presented by Hameed and Riordan [4] , tachypnoea is an early feature of meningococcal disease, which might lead to misdiagnosis with bronchiolitis. Neuroinflammatory factors may also contribute to abnormalities in respiratory movement, including nitric oxide (NO) and prostaglandins, and some cytokines may be upregulated in the brain in several diseases, such as meningitis and septic encephalopathy.…”

mentioning

confidence: 99%

Nitric Oxide and ATP-Sensitive Potassium Channels Mediate Lipopolysaccharide-Induced Depression of Central Respiratory-Like Activity in Brain Slices

Wang

Chen

et al. 2012

Neurosignals

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Infection may result in early abnormalities in respiratory movement, and the mechanism may involve central and peripheral factors. Peripheral mechanisms include lung injury and alterations in electrolytes and body temperature, but the central mechanisms remain unclear. In the present study, brainstem slices harvested from rats were stimulated with lipopolysaccharide at different doses. Central respiratory activities as demonstrated by electrophysiological activity of the hypoglossal rootlets were examined and the mechanisms were investigated by inhibiting nitric oxide synthase and ATP-sensitive potassium channels. As a result, 0.5 µg/ml lipopolysaccharide mainly caused inhibitory responses in both the frequency and the output intensity, while 5 µg/ml lipopolysaccharide caused an early frequency increase followed by delayed decreases in both the frequency and the output intensity. At both concentrations the inhibitory responses were fully reversed by inhibition of nitric oxide synthase with Nω-nitro-L-arginine methyl ester hydrochloride (20 µM), and by inhibition of ATP- sensitive potassium channels with glybenclamide (100 µM). These results show that direct lipopolysaccharide challenge altered central respiratory activity in dose- and time- related manners. Nitric oxide synthase and ATP-sensitive potassium channels may be involved in the respiratory changes.

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Meningococcal Disease Presenting as Bronchiolitis

Cited by 2 publications

References 8 publications

Meningococcal Disease Awareness: Clinical and Epidemiological Factors Affecting Prevention and Management in Adolescents

Meningococcal Disease Awareness: Clinical and Epidemiological Factors Affecting Prevention and Management in Adolescents

Nitric Oxide and ATP-Sensitive Potassium Channels Mediate Lipopolysaccharide-Induced Depression of Central Respiratory-Like Activity in Brain Slices

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