Cryptococcosis in the central nervous system is an infrequent infection in immunocompetent patients. The Cryptococcus complex of which Cryptococcus neoformans and Cryptococcus gattii is a part, cause infection that starts in the lung and later causes infection in the central nervous system; being more frequent in immunocompetent patients Cryptococcus gattii and in immunocompromised patients Cryptococcus neoformans; having as a relevant clinical presentation headache due to increased intracranial pressure; this article reports a clinical case of a 46-year-old male, immunocompetent, who attends due to headache with warning signs, the warning signs being: first episode of headache with characteristics of increased intracranial pressure, which does not subside with analgesia, performing complementary studies, these being neuroimaging and lumbar puncture with identification with polymerase chain reaction in cerebrospinal fluid, in which infection in the central nervous system by Cryptococcus gattii is identified and during hospital stay a pulmonary nodule with cryptococoma is identified, for which lobectomy was performed, and treatment with amphotericin B and fluconazole was ordered.