Meniscal Repair

Miller, Mark D.; Ritchie, Joseph R.; Gomez, Ben A.; Royster, R. M.; DeLee, Jesse C.

doi:10.1177/036354659502300121

Cited by 46 publications

(3 citation statements)

References 20 publications

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“…Finally, it should be noted that a repaired meniscus may not function as well as a normal one under in vivo conditions. It has been shown experimentally that the scar in the repair area does not have normal meniscal tissue characteristics [14,22]. This abnormal tissue may adversely affect the load-bearing properties of the meniscus and make it also more vulnerable to degeneration.…”

Section: Discussionmentioning

confidence: 99%

Long-term results of meniscus repair and meniscectomy: a 13-year functional and radiographic follow-up study

Rockborn¹,

Messner²

2000

Knee Surgery, Sports Traumatology, Arthroscopy

112

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This study investigated the long-term outcome of common meniscus treatment (meniscectomy, repair). A consecutive series of 30 patients with open meniscus repair were compared retrospectively to 30 patients who had an arthroscopic partial or subtotal meniscectomy. The groups were matched according to sex, age, meniscus lesion, and follow-up time. The patients were aged 13-43 years at the time of operation; all had intact cruciate ligaments, and none had had previous surgery on the knee. Patients were reexamined at a mean of 13 years after the operation. In addition, for a subgroup of 22 matched pairs, data were available from a 7-year follow-up. Four of the repaired menisci did not heal, and another three reruptured during the 13-year follow-up; these menisci were all excised (23%). Meniscal remnant surgery was needed in 6 cases (20%) after initial meniscectomy. At the 13-year follow-up there was no difference between the groups in knee function, subjective complaints, or manual findings. Almost 90% of the patients in both groups had no knee problems during daily activities. At the late follow-up radiographic signs for bone spurs, sclerosis, or flattening of the femoral condyle were found in around half of the cases in each group. Three patients (10%) with initial repair and 8 (27%) with meniscectomy had minor joint space reduction, but no patient had more severe radiographic changes. After 7 years (subgroup) joint space reduction was more common after initial meniscectomy than after repair (P < 0.05). After 13 years the incidence and severity of arthrosis did not differ significantly between the two groups, even when only the successful repairs were compared to meniscectomy (P = 0.06).

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Section: Discussionmentioning

confidence: 99%

Long-term results of meniscus repair and meniscectomy: a 13-year functional and radiographic follow-up study

Rockborn¹,

Messner²

2000

Knee Surgery, Sports Traumatology, Arthroscopy

112

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“…Both the width and length of the goat meniscus are smaller than humans and there are differences in surrounding ligaments and passive range of motion 31 , 32 . Despite these potential differences between goats and humans, the goat model is still promising as it bears a close resemblance to human knee anatomy and has similar vascular properties 25 , 26 , 32 . Analysis of a wider range of time points and anatomical locations are needed to fully realize the potential of goats as animal models for meniscal healing.…”

Section: Discussionmentioning

confidence: 99%

“…Among large animals, the meniscal anatomy of the goat has been described as the most similar to humans. The healing properties of menisci in goats have also been shown to be similar to those of humans 26 . Further, previous studies on meniscal repair and healing have been done successfully using a goat model 24 , 26 – 28 .…”

Section: Introductionmentioning

confidence: 88%

A pilot study to assess the healing of meniscal tears in young adult goats

Fedje-Johnston

Johnson

Tóth

et al. 2021

Sci Rep

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Meniscal tears are a common orthopedic injury, yet their healing is difficult to assess post-operatively. This impedes clinical decisions as the healing status of the meniscus cannot be accurately determined non-invasively. Thus, the objectives of this study were to explore the utility of a goat model and to use quantitative magnetic resonance imaging (MRI) techniques, histology, and biomechanical testing to assess the healing status of surgically induced meniscal tears. Adiabatic T1ρ, T2, and T2* relaxation times were quantified for both operated and control menisci ex vivo. Histology was used to assign healing status, assess compositional elements, and associate healing status with compositional elements. Biomechanical testing determined the failure load of healing lesions. Adiabatic T1ρ, T2, and T2* were able to quantitatively identify different healing states. Histology showed evidence of diminished proteoglycans and increased vascularity in both healed and non-healed menisci with surgically induced tears. Biomechanical results revealed that increased healing (as assessed histologically and on MRI) was associated with greater failure load. Our findings indicate increased healing is associated with greater meniscal strength and decreased signal differences (relative to contralateral controls) on MRI. This indicates that quantitative MRI may be a viable method to assess meniscal tears post-operatively.

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Animal models for meniscus repair and regeneration

Deponti

Giancamillo

Scotti

et al. 2013

J Tissue Eng Regen Med

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The meniscus plays an important role in knee function and mechanics. Meniscal lesions, however, are common phenomena and this tissue is not able to achieve spontaneous successful repair, particularly in the inner avascular zone. Several animal models have been studied and proposed for testing different reparative approaches, as well as for studying regenerative methods aiming to restore the original shape and function of this structure. This review summarizes the gross anatomy, function, ultrastructure and biochemical composition of the knee meniscus in several animal models in comparison with the human meniscus. The relevance of the models is discussed from the point of view of basic research as well as of clinical translation for meniscal repair, substitution and regeneration. Finally, the advantages and disadvantages of each model for various research directions are critically discussed.

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Meniscal Repair

Cited by 46 publications

References 20 publications

Long-term results of meniscus repair and meniscectomy: a 13-year functional and radiographic follow-up study

Long-term results of meniscus repair and meniscectomy: a 13-year functional and radiographic follow-up study

A pilot study to assess the healing of meniscal tears in young adult goats

Animal models for meniscus repair and regeneration

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