Meniscal scaffolds: Early experience and review of the literature

Spencer, S.J.; Saithna, Adnan; Carmont, Michael R.; Dhillon, M.; Thompson, P.; Spalding, Tim

doi:10.1016/j.knee.2012.01.006

Cited by 86 publications

(60 citation statements)

References 23 publications

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“…Indeed, processing of ovine meniscus tissue to improve porosity and interconnectivity as a xenogeneic meniscus scaffold has potential. 54 There are growing data to show that the use of dynamic culture or fluid mixing can be optimized to modulate the spatial heterogeneity of engineered menisci as well as the correlated mechanical properties. [55][56][57] Compressive deformation or hydrostatic pressure has been shown to enhance the structure and function of engineered meniscus tissues.…”

Section: Biological Augmentation and Tissue Engineering Approaches Inmentioning

confidence: 99%

Biological Augmentation and Tissue Engineering Approaches in Meniscus Surgery

Moran

Busilacchi

Lee

et al. 2015

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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Section: Biological Augmentation and Tissue Engineering Approaches Inmentioning

confidence: 99%

Biological Augmentation and Tissue Engineering Approaches in Meniscus Surgery

Moran

Busilacchi

Lee

et al. 2015

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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“…However, some important limitations are still unsolved, including the possibility of a reduction in the size or complete degradation of the implant. In addition, tissue growth inside the implant must be further studied in vivo because some authors argue that the implant tissue should exhibit the same biomechanical characteristics as those of native meniscal tissue [28].…”

Section: Collagen Matrix Scaffoldsmentioning

confidence: 99%

Updates in biological therapies for knee injuries: menisci

Kaleka

Debieux

Astur

et al. 2014

Curr Rev Musculoskelet Med

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The preservation of meniscal tissue is paramount for long-term joint function, especially in younger patients who are athletically active. Many studies have reported encouraging results following the repair of meniscus tears, including both simple longitudinal tears located in the periphery and complex multiplanar tears that extend into the central third avascular region. However, most types of meniscal lesions are managed with a partial meniscectomy. Options to restore the meniscus range from an allograft transplantation to the use of synthetic and biological technologies. Recent studies have demonstrated good long-term outcomes with meniscal allograft transplantation, although the indications and techniques continue to evolve, and the long-term chondroprotective potential of this approach has yet to be determined. Several synthetic implants, most of which are approved in the European market, have shown some promise for replacing part of or the entire meniscus, including collagen meniscal implants, hydrogels, and polymer scaffolds. Currently, there is no ideal implant generated by means of tissue engineering. However, meniscus tissue engineering is a fast developing field that promises to develop an implant that mimics the histologic and biomechanical properties of a native meniscus.

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“…Firstly, the size of the CMI® reduced during follow-up [27][28][29]. Secondly, the signal intensity does not resemble that of the native meniscus, either for short follow-up [27,28] or for follow-up periods exceeding ten years [26,29].…”

Section: Partial Meniscal Substitutesmentioning

confidence: 99%

“…Figure 1c and d show a representative MRI of a CMI® implanted knee 12 months post-surgery. Based on second-look arthroscopies at a mean of 12.8 months and MR scans at a mean of 19 months, Spencer et al suggest that the regenerated tissue is not fibrocartilage [27]. Hence, the mechanism of action of the CMI® is not fully understood.…”

Section: Partial Meniscal Substitutesmentioning

confidence: 99%