Meniscal transplantation and regeneration using functionalized polyurethane bionic scaffold and digital light processing 3D printing

Ding, Guocheng; Li, Xinpan; Sun, Muyang; He, Yangyang; Zhao, Fengyuan; Wu, Tong; Wang, Junyan; Ren, Shuang; Shi, Weili; Xu, Long; Hu, Xiaoqing; Huang, Wei; Yu, Ran; Ao, Yingfang

doi:10.1016/j.cej.2021.133861

Cited by 21 publications

(15 citation statements)

References 50 publications

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“…They showed that in-vivo experiments, the PDAmodified scaffolds were significantly better at enhancing adhesion and proliferation of cells, leading to the better repair of osteochondral defects and cartilage regeneration. Ding et al (2022) coated the PU 3D printed scaffold with PDA to enhance biocompatibility and hydrophilicity as well as increase the ability to recruit endogenous MSCs. In addition to reducing the water contact angle of scaffolds, PDA-modification resulted in higher cell viability, uniform adhesion, and improved cell proliferation.…”

Section: Cartilage Regenerationmentioning

confidence: 99%

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

Tolabi

Bakhtiary

Sayadi

et al. 2022

Front. Bioeng. Biotechnol.

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Increasing concern about age-related diseases, particularly musculoskeletal injuries and orthopedic conditions, highlights the need for strategies such as tissue engineering to address them. Surface modification has been developed to create pro-healing interfaces, personalize scaffolds and provide novel medicines. Polydopamine, a mussel-inspired adhesive polymer with highly reactive functional groups that adhere to nearly all substrates, has gained attention in surface modification strategies for biomaterials. Polydopamine was primarily developed to modify surfaces, but its effectiveness has opened up promising approaches for further applications in bioengineering as carriers and nanoparticles. This review focuses on the recent discoveries of the role of polydopamine as a surface coating material, with focus on the properties that make it suitable for tackling musculoskeletal disorders. We report the evolution of using it in research, and discuss papers involving the progress of this field. The current research on the role of polydopamine in bone, cartilage, muscle, nerve, and tendon regeneration is discussed, thus giving comprehensive overview about the function of polydopamine both in-vitro and in-vivo. Finally, the report concludes presenting the critical challenges that must be addressed for the clinical translation of this biomaterial while exploring future perspectives and research opportunities in this area.

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Section: Cartilage Regenerationmentioning

confidence: 99%

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

Tolabi

Bakhtiary

Sayadi

et al. 2022

Front. Bioeng. Biotechnol.

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“…According to incomplete statistics, about 60% of people over the age of 40 have the incidence rate. And this group is often accompanied by meniscus tearing and other phenomena as they grow older ( Ding et al, 2022 ). The age ratio of meniscus injuries from 2013 to 2020 is shown in Figure 1 :…”

Section: Koa Exercise Therapy Based On Kalman Filter Theorymentioning

confidence: 99%

Application of Tissue Engineered Nanomaterials in Meniscus Sports Injury Repair

Han

2022

Front. Bioeng. Biotechnol.

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In daily life and sports activities, the knee joint is the dominant joint. Movements such as walking upstairs, running, and walking require the knee joint to function. The principle of tissue engineering and the technical methods of molecular biology to construct functional meniscus replacement products in vitro have become an ideal method to fundamentally solve the meniscus injury. This paper aims to study the application of tissue engineered nanomaterials in meniscal sports injury repair. In this paper, KOA exercise therapy based on Kalman filter theory is proposed, which has a great effect on the rehabilitation of bone tissue injuries. The experimental results of this paper show that in the number of people with meniscus injuries in 2013, the percentage of people younger than 25 years old was 13%, and the percentage of people younger than 25 years old in 2020 was 12%, which did not change much. However, the percentage of people over 40 years old was 57% in 2013, and by 2020, the percentage is 66%. Although the increase is not large, the percentage of people over the age of 40 is the highest every year, which means that older people have a higher proportion of meniscal injuries.

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“…With excellent permeability, diffusivity, and biocompatibility, hydrogels have great potential applications in the biomedical field for tissue engineering scaffolds and artificial tissues. − However, due to the inhomogeneous network structure and lack of energy dissipation mechanism, they are generally weak in mechanical properties, limiting their wider applications. , Especially, for certain applications, such as an artificial ligament, tendon, or meniscus, hydrogels are required to achieve multiple combined extreme properties. For example, the native ligament or tendon has a tensile strength of 10–100 MPa and a fracture toughness of 20–30 kJ m –2 , while the native meniscus has a tensile strength of 15–30 MPa and a tensile modulus of 70–150 MPa. , Therefore, reinforcement of the hydrogel to achieve extreme mechanical properties such as these biological hydrogels has always been an important research topic for scientists.…”

Section: Introductionmentioning

confidence: 99%

“…The development of 3D printing technologies provides a new avenue for preparing hydrogel objects with complex structures, among which the extrusion-based direct ink writing (DIW) is the most widely used technology in the field of hydrogels. However, the resolution of DIW is generally greater than 100 μm, which is mainly limited by the dimension of the extrusion nozzle. − Digital light processing (DLP) printing is a type of photopolymerization-based 3D printing technology in which the liquid photosensitive resin is selectively cured upon UV irradiation, and an entire layer of resin can be cured at one exposure. ,, Compared with extrusion-based printing technologies, it has great advantages in printing resolution and efficiency, which is favorable for the construction of artificial tissues or scaffolds with biomimetic 3D microstructures . However, the low solubility of the hydrophobic photo-initiators and the lack of high-efficient aqueous photo-initiators limit the development of DLP printing of hydrogels …”

Section: Introductionmentioning

confidence: 99%

“…For example, the native ligament or tendon has a tensile strength of 10−100 MPa and a fracture toughness of 20−30 kJ m −2 , while the native meniscus has a tensile strength of 15−30 MPa and a tensile modulus of 70−150 MPa. 6,7 Therefore, reinforcement of the hydrogel to achieve extreme mechanical properties such as these biological hydrogels has always been an important research topic for scientists.…”

Section: Introductionmentioning

confidence: 99%

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A Universal and Simple Method to Obtain Hydrogels with Combined Extreme Mechanical Properties and Their Application as Tendon Substitutes

Ding

et al. 2022

ACS Appl. Mater. Interfaces

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With the development of biomedical engineering, the preparation of hydrogels with combined extreme mechanical properties similar to those of some biological hydrogels becomes an important research topic for scientists. In this work, a single-network hydrogel with combined extreme mechanical properties is prepared through a simple and universal method, wherein the strength, elongation at break, toughness, and fracture energy of the hydrogel WPU-3PAAm-6PAN are achieved at 24.7 MPa, 544.0%, 68.9 MJ m–3, and 37.2 kJ m–2, respectively. Herein, a series of photosensitive resins in emulsion form are synthesized, and due to the water–oil diphasic characteristic, hydrophobic monomers and high-efficient hydrophobic photo-initiators are adopted into the resins, which can significantly improve the mechanical properties of the hydrogels due to the hydrophobic association effect and solve the biggest barrier of low curing rate in digital light processing (DLP) fabrication of hydrogels, respectively. Moreover, the simple and facile method to obtain robust and tough hydrogels can be universally applied to other polymer systems. Combined with the excellent mechanical properties and printing ability, the hydrogels with optimized structures are fabricated through DLP printing technology and applied as tendon substitutes. The tendon substitutes exhibit superior performance for mechanical connection and regeneration of collagen fibers. Although further clinical research is required, the hydrogels have great potential applications in various biological areas.

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Meniscal transplantation and regeneration using functionalized polyurethane bionic scaffold and digital light processing 3D printing

Cited by 21 publications

References 50 publications

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

Application of Tissue Engineered Nanomaterials in Meniscus Sports Injury Repair

A Universal and Simple Method to Obtain Hydrogels with Combined Extreme Mechanical Properties and Their Application as Tendon Substitutes

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