Meniscus allograft transplantation: a current concepts review

Lubowitz, James H.; Verdonk, Peter; Reid, John B.; Verdonk, René

doi:10.1007/s00167-006-0216-5

Cited by 146 publications

(117 citation statements)

References 118 publications

(243 reference statements)

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“…Various procedures are undertaken prior to transplant, but not usually as extensive as described for the trachea. Menisci have been used after maintaining in culture whilst some safety checks are performed (Lubowitz et al, 2007) or more generally following cryopreservation via various protocols. Depending on how this is done, it may kill some of the resident cells prior to implantation.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus

Roberts¹,

Turner²,

Evans³

2016

Comprehensive Biotechnology

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Synopsis/AbstractThe intervertebral disc in the spine and the meniscus in the knee are two fibrocartilaginous tissues which commonly are injured or become degenerate, causing significant clinical problems. The principals of tissue engineering, which are applicable elsewhere in the body, hold true for the disc and meniscus. Whilst there are some similarities with articular cartilage in terms of the molecules present, these fibrocartilages have their own peculiarities, some of which can be quite challenging. Following a description of the structure and anatomy of the disc and meniscus and the current clinical treatments, the different strategies for biological repair are described focusing particularly on cell therapy. The types of cells and scaffolds being investigated and how these can be modified are discussed.

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Section: Tissue Engineeringmentioning

confidence: 99%

Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus

Roberts¹,

Turner²,

Evans³

2016

Comprehensive Biotechnology

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“…As a consequence, surgery is less demanding and immunosuppressive therapy is not needed (Jackson et al, 1992). Meniscal transplantation is actually the only biologic option available for the symptomatic, totally meniscectomised, non-osteoarthritic, stable and wellaligned knee Lubowitz et al, 2007). On the other hand, although this technique is not new (Milachowski et al, 1989), the long-term effects, especially in terms of chondroprotection and prevention of osteoarthritis, still remain to be proven (Wirth et al, 2002).…”

Section: Meniscal Transplantationmentioning

confidence: 99%

“…On the other hand, although this technique is not new (Milachowski et al, 1989), the long-term effects, especially in terms of chondroprotection and prevention of osteoarthritis, still remain to be proven (Wirth et al, 2002). Limitations of this procedure include tissue availability, risk of immune reaction, risk of disease transmission, and graft sizing (Lubowitz et al, 2007).…”

Section: Meniscal Transplantationmentioning

confidence: 99%

“…Regarding the type of allograft, four have been used: cryopreserved, deep-frozen (fresh-frozen), fresh, and lyophilised (freeze-dried) (Cole et al, 2003;Lubowitz et al, 2007). Fresh grafts present the advantage of being rich in viable cells and this has been demonstrated to improve mechanical integrity following transplantation, determining a lower failure rate of the procedure compared to those of deep-frozen and lyophilised grafts (Siegel and Roberts, 1993;Verdonk et al, 2005).…”

Section: Meniscal Transplantationmentioning

confidence: 99%

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Meniscus repair and regeneration: review on current methods and research potential

Scotti

Hirschmann

Antinolfi

et al. 2013

eCM

130

123

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Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage. Research proposed a number of experimental approaches encompassing all the typical strategies of regenerative medicine: cellfree scaffolds, gene therapy, intra-articular delivery of progenitor cells, biological glues for enhanced bonding of reparable tears, partial and total tissue engineered meniscus replacement. None of these approaches has been completely successful and can be considered suitable for all patients, as meniscal tears require specific and patientrelated treatments depending on the size and type of lesion. Recent advances in cell biology, biomaterial science and bioengineering (e.g., bioreactors) have now the potential to drive meniscus regeneration into a series of clinically relevant strategies. In this tutorial paper, the clinical need for meniscus regeneration strategies will be explained, and past and current experimental studies on meniscus regeneration will be reported.

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“…Even considering the different processing, sterilization, storage, surgical, and assessment procedures, the positive results in 85 % of the [34][35][36][37]. Several factors influence the clinical outcome following transplantation and are categorized into knee-specific factors (ie, chondral damage, ligamentous stability, axial alignment, prior surgery), graft-specific factors (ie, medial vs lateral side, the method of preservation, sterilization, the sizing method), surgeon-specific factors (ie, surgeon experience, the insertion method, graft fixation, concomitant procedures) and rehabilitation-specific factors (ie, the range of passive motion, weight bearing, continuous passive motion, return to activities) [36].…”

Section: Meniscus Allograft Transplantationmentioning

confidence: 99%

Updates in biological therapies for knee injuries: menisci

Kaleka

Debieux

Astur

et al. 2014

Curr Rev Musculoskelet Med

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The preservation of meniscal tissue is paramount for long-term joint function, especially in younger patients who are athletically active. Many studies have reported encouraging results following the repair of meniscus tears, including both simple longitudinal tears located in the periphery and complex multiplanar tears that extend into the central third avascular region. However, most types of meniscal lesions are managed with a partial meniscectomy. Options to restore the meniscus range from an allograft transplantation to the use of synthetic and biological technologies. Recent studies have demonstrated good long-term outcomes with meniscal allograft transplantation, although the indications and techniques continue to evolve, and the long-term chondroprotective potential of this approach has yet to be determined. Several synthetic implants, most of which are approved in the European market, have shown some promise for replacing part of or the entire meniscus, including collagen meniscal implants, hydrogels, and polymer scaffolds. Currently, there is no ideal implant generated by means of tissue engineering. However, meniscus tissue engineering is a fast developing field that promises to develop an implant that mimics the histologic and biomechanical properties of a native meniscus.

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Meniscus allograft transplantation: a current concepts review

Cited by 146 publications

References 118 publications

Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus

Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus

Meniscus repair and regeneration: review on current methods and research potential

Updates in biological therapies for knee injuries: menisci

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