Menopause hormone therapy, migraines, and thromboembolism

Khandelwal, Sunila; Meeta, Meeta; Tanvir, Tanvir

doi:10.1016/j.bpobgyn.2021.11.011

Cited by 2 publications

(2 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to recent studies, it is estimated that approximately 1 in 10 individuals worldwide experience migraines ( Woldeamanuel and Cowan, 2017 ). Women are more commonly affected than men, with hormonal fluctuations playing a significant role in triggering migraine attacks ( Khandelwal et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Venous thromboembolism (VTE), primarily comprising deep vein thrombosis and its associated complication, pulmonary embolism, has the potential to cause severe and life-threatening consequences ( Lutsey and Zakai, 2023 ). Several observational studies have reported an increased risk of VTE among individuals with migraine ( Bushnell et al, 2009 ; Wabnitz and Bushnell, 2015 ; Khandelwal et al, 2022 ). A large population based cohort study conducted by Adelborg et al (2018) involving over 50,000 migraine participants found that migraine patients had a significantly higher risk of VTE compared to controls.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study

Wu,

Niu,

Liu

2024

Front. Genet.

View full text Add to dashboard Cite

ObjectivePrevious observational studies have reported an increased risk of venous thromboembolism (VTE) among individuals with migraine. This study aimed to investigate the causal effect of migraine on the development of VTE, as well as explore the genetic correlation between them.MethodsWe conducted a two-sample Mendelian randomization (MR) study using publicly available summary statistics from large-scale genome-wide association studies for migraine and VTE. Linkage disequilibrium score regression analysis was performed to estimate the genetic correlation between migraine and VTE.ResultsThere were several shared risk variants (p-value < 5 × 10−8) between migraine and VTE. Linkage disequilibrium score regression analysis found a significant positive genetic correlation between migraine and VTE. The genetic correlations based on two migraine datasets were 0.208 (se = 0.031, p-value = 2.91 × 10−11) and 0.264 (se = 0.040, p-value = 4.82 × 10−11), respectively. Although main MR analysis showed that migraine was associated with an increased risk of VTE (odds ratio = 1.069, 95% confidence interval = 1.022–1.118, p-value = 0.004), the association attenuated to non-significance when using several other MR methods and using another set of genetic instruments. In addition, evidence of heterogeneity was found. Reverse MR analysis showed VTE was associated with increased risk of migraine with aura (odds ratio = 1.137, 95% confidence interval = 1.062–1.218, p-value = 2.47 × 10−4) with no evidence of pleiotropy and heterogeneity.ConclusionWe showed suggestive evidence indicating an association between migraine and increased risk of VTE. Additionally, we found robust evidence suggesting that VTE is associated with an increased risk of migraine. The positive genetic correlation indicates that migraine and VTE has shared genetic basis. Further investigations will be necessary to address potential sex-specific effects in the analysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study

Wu,

Niu,

Liu

2024

Front. Genet.

View full text Add to dashboard Cite

show abstract

Reviewing migraine-associated pathophysiology and its impact on elevated stroke risk

Ravi,

Osouli Meinagh,

Bavarsad Shahripour

2024

Front. Neurol.

View full text Add to dashboard Cite

Migraine affects up to 20 percent of the global population and ranks as the second leading cause of disability worldwide. In parallel, ischemic stroke stands as the second leading cause of mortality and the third leading cause of disability worldwide. This review aims to elucidate the intricate relationship between migraine and stroke, highlighting the role of genetic, vascular, and hormonal factors. Epidemiological evidence shows a positive association between migraine, particularly with aura, and ischemic stroke (IS), though the link to hemorrhagic stroke (HS) remains inconclusive. The shared pathophysiology between migraine and stroke includes cortical spreading depression, endothelial dysfunction, and genetic predispositions, such as mutations linked to conditions like CADASIL and MELAS. Genetic studies indicate that common loci may predispose individuals to both migraine and stroke, while biomarkers such as endothelial microparticles and inflammatory cytokines offer insights into the underlying mechanisms. Additionally, hormonal influences, particularly fluctuations in estrogen levels, significantly impact migraine pathogenesis and stroke risk, highlighting the need for tailored interventions for women. The presence of a patent foramen ovale (PFO) in migraineurs further complicates their risk profile, with device closure showing promise in reducing stroke occurrence. Furthermore, white matter lesions (WMLs) are frequently observed in migraine patients, suggesting potential cognitive and stroke risks. This review hopes to summarize the links between migraine and its associated conditions and ischemic stroke, recognizing the profound implications for clinical management strategies for both disorders. Understanding the complex relationship between migraine and ischemic stroke holds the key to navigating treatment options and preventive interventions to enhance overall patient outcomes.

show abstract

Menopause hormone therapy, migraines, and thromboembolism

Cited by 2 publications

References 67 publications

Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study

Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study

Reviewing migraine-associated pathophysiology and its impact on elevated stroke risk

Contact Info

Product

Resources

About