Menstrual cycle characteristics and reproductive hormone levels in women exposed to atrazine in drinking water

Cragin, Lori A.; Kesner, James S.; Bachand, Annette M.; Barr, Dana Boyd; Meadows, Juliana W.; Krieg, Edward F.; Reif, John S.

doi:10.1016/j.envres.2011.09.009

Cited by 83 publications

(36 citation statements)

References 55 publications

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“…However, it is still an open question whether ATRZ, via an effect on P 4 , is able to adversely affect a woman's cycle. More recently, a preliminary epidemiological report indicated menstrual irregularities in women within a geographic region of extensive ATRZ usage compared with an area where the usage is much more limited (Cragin et al 2011). The follicular phase was found to be lengthened, although there did not appear to be an association during this phase with urinary levels of the P 4 metabolite pregnanediol 3-glucuronide (Pd3G).…”

Section: Discussionmentioning

confidence: 99%

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

et al. 2013

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Multiple exposures to the herbicide atrazine (ATRZ) were shown to suppress the LH surge in both cycling female rats and those ovariectomized (OVX) and primed with estradiol (E 2 ). A single ATRZ administration was found to induce a prompt and marked increase in progesterone (P 4 ). As exogenous P 4 is known to have a differential effect on the LH surge depending on its temporal relationship with the surge, it was hypothesized that a single treatment in an OVX, E 2 -primed rat would augment the surge, whereas several exposures would cause a decrease. Following four daily treatments with 100 mg/kg, LH surge was suppressed. In contrast, a single ATRZ exposure elevated the surge. Two treatments were without effect. The single administration caused a large increase in P 4 at 30 and 60 min that was likely attributable to adrenal secretion. Four exposures also elevated P 4 after the final treatment, although the duration of the increase was shortened. A single treatment with 0, 10, 30, and 100 mg/kg ATRZ showed similar elevations at the highest concentration in P 4 , the LH peak, and area under the curve (AUC), whereas four exposures reduced the AUC. An increase at 1 h in the expression of Kiss1 in the anteroventral periventricular nucleus suggests that this regional kisspeptin neuronal population has a role in the ATRZ augmentation of the surge. These data support the hypothesis that ATRZ-induced changes in adrenal P 4 can either augment or attenuate the surge depending on the temporal proximity of exposure to the rise in LH.

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Section: Discussionmentioning

confidence: 99%

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

et al. 2013

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“…Atrazine exposure through daily drinking water is suggested to be linked to increased incidences of some cancers, altered development of reproductive organs, compromised immune development, and other adverse health effects in humans, but much more work is needed to confirm these links (Cragin et al, 2011;Freeman et al, 2011). Although we know there is a link to atrazine and various adverse health effects, it is still not understood if atrazine is confidently a carcinogen nor how it mechanistically plays a toxic role during human development.…”

Section: Discussionmentioning

confidence: 99%

Water Contaminated With the Herbicide Atrazine: Alteration of Cancer Associated Tumor Protein D52-like 1 (tpd52l1) Gene Using the Zebrafish Model

Thanki¹

2017

JPUR

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“…[4] In a recent study, atrazine was shown to consistently exceed the water quality benchmark, likely because of runoff from usage at nearby locations. [5] The presence of atrazine has been detected in cattle, rat, dog, mouse, [6][7][8][9][10] and specific human populations such as agricultural workers, [4,[11][12][13][14] as well as in homes not located on farms. [15] In this study, atrazine levels in water, foods, and urine samples obtained from young students at an urban university were measured.…”

Section: Introductionmentioning

confidence: 99%

Presence of Agricultural Herbicide Atrazine in Water, Foods, and Human Urine Samples

Concilla¹

2017

IJEMA

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Abstract:Atrazine is a commonly used water-soluble agricultural herbicide in the United States. In this study, we measured the atrazine levels in water, beverages, foods, and urine samples obtained from young students at an urban university. The effects of physiological and behavioral factors were examined. Our results show that water samples obtained from Lake Erie and tap water both contained very low level of atrazine. Beverages and foods had various levels of atrazine contamination. Atrazine was also detected in the urine samples and mid-term physical activity appeared to be a factor to reduce the atrazine level in these subjects.

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Menstrual cycle characteristics and reproductive hormone levels in women exposed to atrazine in drinking water

Cited by 83 publications

References 55 publications

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

Water Contaminated With the Herbicide Atrazine: Alteration of Cancer Associated Tumor Protein D52-like 1 (tpd52l1) Gene Using the Zebrafish Model

Presence of Agricultural Herbicide Atrazine in Water, Foods, and Human Urine Samples

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