This part discusses sanitation from the perspectives of health and well-being. In particular, we focus on the socio-cultural aspects of water, sanitation, and hygiene (WASH) in relation to health. First, we discuss the social determinants of health (SDH) with an in-depth focus on the gender, cultural, and economic disparities that impact access to quality sanitation. We also spotlight sanitation workers, who play a significant part in existing sanitation systems yet unquantified and ostracized. Furthermore, as theoretical underpinnings, we review methodologies to behavioral changes including information dissemination, education approach, and community-based approach. Subsequently, we introduce the three chapters that constitute this part. Chapter 10.1007/978-981-16-7711-3_7 examines relationships between child health (e.g., undernutrition and diarrhea) and its associated factors (e.g., water, sanitation, and hand hygiene) in Indonesia. In Chap. 10.1007/978-981-16-7711-3_8, we argue the transfer of health risks in sanitation and its social allocation (i.e., genders) in Vietnam. Finally, in Chap. 10.1007/978-981-16-7711-3_9, we introduce Participatory Action Research (PAR) involving local children and youth in tackling WASH issues in Sub-Saharan Africa (Zambia). In the end, we reemphasize SDH by mentioning socio-cultural aspects of health and attitudinal and behavioral changes on WASH in society through community-based approach.