Mental disorders in offspring of parents with bipolar and major depressive disorders

Vandeleur, Caroline L.; Rothen, Stéphane; Gholam‐Rezaee, Mehdi; Castelao, Enrique; Vidal, Sonia; Favre, Sophie; Ferrero, François; Halfon, Olivier; Fumeaux, Pierre; Merikangas, Kathleen R.; Aubry, Jean‐Michel; Burstein, Marcy; Preisig, Martin

doi:10.1111/j.1399-5618.2012.01048.x

Cited by 82 publications

(86 citation statements)

References 43 publications

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“…First, this study extends previous reports in demonstrating that young subjects at high genetic risk for BD were also at significantly increased risk for developing a broad range of psychopathology (Birmaher et al, 2009;Duffy et al, 2010;Duffy et al, 2014;Hillegers et al, 2005;Leopold et al, 2014;Nurnberger et al, 2011;Vandeleur et al, 2012;Wals et al, 2001;Whalley et al, 2011). Specifically, we found that AR subjects were more likely to develop depressive, anxiety and behavioural disorders compared to controls.…”

Section: Accepted Manuscript 13supporting

confidence: 85%

“…The odds of an affective disorder were 4.9 times greater for those living in a single parent home than for those living with both biological parents. This is consistent with a finding from a Swiss high-risk study (Vandeleur et al, 2012) which found that lower rates of affective disorders in AR offspring were associated with living with both biological parents, and is in line with the broader literature on the increased rate of later mental illness in children who were exposed to parental marital disruption during their developmental years (Gilman et al, 2003;Strohschein et al, 2005;Cherlin et al, 1998). However, as our findings are cross-sectional we cannot exclude the alternative possibility that the disruption in the parental relationships may be due to the impact of severe affective illness in these families.…”

supporting

confidence: 89%

“…Fifty-four percent had experienced some mood disorder (mainly depression), 27% an anxiety disorder, 25% a substance use disorder (SUD), and 8% a disruptive behavioural disorder. Similarly, cross-sectional comparisons of populations of high-risk young people have also reported a greater prevalence of lifetime nonaffective psychiatric diagnoses such as anxiety, disruptive behavioural disorders and SUDs when compared to control and major depressive disorder samples (Birmaher et al, 2009;Duffy et al, 2014;Hillegers et al, 2005;Leopold et al, 2014;Nurnberger et al, 2011;Shaw et al, 2005;Vandeleur et al, 2012;Wals et al, 2001;Whalley et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

What clinical features precede the onset of bipolar disorder?

Perich¹,

Lau²,

Hadži-Pavlović³

et al. 2015

Journal of Psychiatric Research

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Despite a growing number of reports, there is still limited knowledge of the clinical features that precede the onset of bipolar disorder (BD). To explore this, we investigated baseline data from a prospectively evaluated longitudinal cohort of subjects aged 12-30 years to compare: first, lifetime rates of clinical features between a) subjects at increased genetic risk for developing BD ('AR'), b) participants from families without mental illness ('controls'), and c) those with established BD; and, second, prior clinical features that predict the later onset of affective disorders in these same three groups. This is the first study to report such comparisons between these three groups (though certainly not the first to compare AR and control samples). 118 AR participants with a parent or sibling with BD (including 102 with a BD parent), 110 controls, and 44 BD subjects were assessed using semi-structured interviews. AR subjects had significantly increased lifetime risks for depressive, anxiety and behavioural disorders compared to controls. Unlike prior reports, preceding anxiety and behavioural disorders were not found to increase risk for later onset of affective disorders in the AR sample, perhaps due to limited sample size. However, preceding behavioural disorders did predict later onset of affective disorders in the BD sample. The findings that i) AR subjects had higher rates of depressive, anxiety and behavioural disorders compared to controls, and ii) prior behavioural disorders increased the risk to later development of affective disorders in the BD group, suggest the possibility of therapeutic targeting for these disorders in those at high genetic risk for BD.

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Section: Accepted Manuscript 13supporting

confidence: 85%

supporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

What clinical features precede the onset of bipolar disorder?

Perich¹,

Lau²,

Hadži-Pavlović³

et al. 2015

Journal of Psychiatric Research

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“…La media de edad de los individuos en el momento de la evaluación era 17,3 ± 6 (6-30) años, y la escolaridad, 8,5 ± 4,1 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) años. Del total de la muestra, el 54,6% (n = 59) provenía de zonas urbanas.…”

Section: Resultsunclassified

“…Estas investigaciones también han evidenciado un inicio más temprano de psicopatología general y un mayor número de episodios de trastornos afectivos 2,3,9,10 . En otros estudios, la tasa de trastornos disruptivos no ha sido más alta que en los grupos controles o la población general [29][30][31] .…”

Section: Discussionunclassified

Descripción de perfiles psicopatológicos y neurocognitivos de hijos de pacientes con trastorno bipolar tipo I dentro un programa de intervencion multimodal: PRISMA

Palacio-Ortíz

Uribe-Villa

Duque-Rios

et al. 2015

Revista Colombiana de Psiquiatría

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Developmental Trajectory of Body Weight in Youths at Risk for Major Mood Disorders

Adepalli,

Cumby,

Campbell

et al. 2023

JAMA Netw Open

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ImportanceMood disorders are associated with increased body weight, especially in females, but it remains unknown when the weight increase starts.ObjectivesTo examine sex-specific weight trajectories associated with familial mood disorder risk and determine the age at which youth at familial risk for mood disorders begin to diverge in weight from controls.Design, Setting, and ParticipantsThis community-based, single-center, acceleration cohort study of youth at familial risk for mood disorders and controls with yearly follow-ups (mean [SD], 5 [2.1] years) from January 1, 2014, to December 31, 2022, assessed 394 unaffected female and male offspring (aged 3 to 20 years) of parents with or without a mood disorder. Parents with mood (depressive or bipolar) disorders were recruited through adult mental health services. Parents of control participants were matched on age and socioeconomic factors and recruited through acquaintance referrals or schools.ExposuresThe youth in the familial mood risk group had at least 1 parent with a major mood disorder, whereas control youth did not have a parent with a mood disorder.Main Outcomes and MeasuresBody mass indexes (BMIs) were calculated as weight in kilograms divided by height in meters squared from measured weight and height at annual assessments and then converted to age- and sex-adjusted z scores (zBMIs). Repeated-measure regressions examined the association between zBMI and age in youth at familial risk of mood disorders and controls while accounting for sex. Sensitivity analyses accounted for socioeconomic status, prematurity, and birth weight.ResultsOf 394 participants (mean [SD] age, 11.5 [3.6] years; 203 [51.5%] female), youths at familial risk for mood disorders showed overall no difference in body weight (β = 0.12; 95% CI, 0.01-0.24) from controls. A sex-specific difference was detected, with females at familial risk showing a rapid peripubertal increase in body weight, leading to significantly increased zBMIs at 12 years and older compared with controls (β = 0.57; 95% CI, 0.31-0.82) independent of socioeconomic status, prematurity, or birth weight. Males did not differ from controls at any age.Conclusions and RelevanceIn this cohort study, females with a family history of mood disorders were prone to weight gain starting around puberty and predating mood disorder onset. Early interventions aiming to prevent adverse mental and physical outcomes in this vulnerable group need to start in childhood.

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Mental disorders in offspring of parents with bipolar and major depressive disorders

Cited by 82 publications

References 43 publications

What clinical features precede the onset of bipolar disorder?

What clinical features precede the onset of bipolar disorder?

Descripción de perfiles psicopatológicos y neurocognitivos de hijos de pacientes con trastorno bipolar tipo I dentro un programa de intervencion multimodal: PRISMA

Developmental Trajectory of Body Weight in Youths at Risk for Major Mood Disorders

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