The present study related generational status, marital status, parental overprotection (control), and cultural value conflict to self-esteem and depression among first and second-generation Asian Indian immigrant women in the south-midwestern United States. Self-report data from 73 community-dwelling women supported the hypotheses that unmarried and second-generation women would report greater maternal control and cultural value conflict than would married and first-generation women. Secondgenerational status, high maternal control, and high cultural value conflict correlated with higher depressive symptomology; being married, low maternal control, and low cultural value conflict were related to high self-esteem. Regression analyses indicated a mediating role for cultural value conflict for depression symptom predictors, but not for self-esteem predictors. Open-ended response data provided enriched understanding of these women's cultural and family conflicts.