Mental Retardation in Pediatric Candidates for Epilepsy Surgery: The Role of Early Seizure Onset

Vasconcellos, E. C. C.; Wyllie, Elaine; Sullivan, Shawn; Stanford, Lisa D.; Bulacio, Juan; Kotagal, Prakash; Bingaman, William

doi:10.1046/j.1528-1157.2001.12200.x

Cited by 94 publications

(85 citation statements)

References 29 publications

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“…Austin and colleagues (37) found that children with active epilepsy had lower scores on school progress and intellectual self-concept than children with inactive epilepsy. Intractable epilepsy in children with onset before age two has been associated with poor cognitive functioning (38). Moreover, in the sample of children with new-onset seizures, our finding that academic performance among those with recurrent seizures tended to decline over time is consistent with results from previous research (7,8,10,32), emphasizing the importance of identifying academic difficulties among children with seizures as early as possible so that interventions may be implemented that limit the progression of problems.…”

Section: Discussionsupporting

confidence: 89%

Academic performance in children with new-onset seizures and asthma: A prospective study

McNelis

Dunn

Johnson

et al. 2007

Epilepsy & Behavior

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The study purpose was to compare teacher ratings of academic performance (TRP) over 24 months between children with new-onset seizures (N = 121) and new-onset asthma (N = 54) ages 4 to 14 years. At each data collection point (baseline, 12 months, 24 months), children with seizures were placed into two groups according to their recurrent seizure status (yes/no) during that period. Longitudinal linear mixed models were used to explore differences between the asthma group and the two seizure groups and to identify if differences in TRP in children with seizures were associated with age, gender, or use of medication. In the seizure sample, scores for children in both groups (with and without recurrent seizures) initially declined at 12 months; however, at 24 months, children who did not have recurrent seizures improved while children who continued to have recurrent seizures declined. There was a trend for younger children to decline more than older children. Keywords academic achievement; pediatric; epilepsy; school; teacher ratings Children with chronic seizures experience more academic problems than healthy children or children with other chronic health conditions, such as asthma (1-6), and also make less academic progress than would be expected for their age and intelligence quotient (IQ) level, (7,8). In longitudinal studies, children with chronic epilepsy failed to show improvement in academic performance over time and, despite an improvement in their seizure conditions, continued to perform worse than a healthy control group (9) and an asthma comparison sample (10).Correspondence to: Angela M. McNelis. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptEpilepsy Behav. Author manuscript; available in PMC 2008 March 1. Published in final edited form as:Epilepsy Behav. 2007 March ; 10(2): 311-318. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptAlthough the majority of studies of children with chronic seizures have found academic difficulties, studies are less consistent in delineating factors predicting underperformance.Cross-sectional studies have demonstrated associations between academic performance and several demographic, neurological, and seizure-related variables, including age, gender, certain antiepileptic medications (AEDs), and seizure frequency. Younger age at onset of seizures has been associated with higher rates of academic underachievement (7,8,(11)(12)(13). Furthermore, earlier age at onset of recurrent seizures was found to be the strongest predictor of cognitive impairment, including acade...

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Section: Discussionsupporting

confidence: 89%

Academic performance in children with new-onset seizures and asthma: A prospective study

McNelis

Dunn

Johnson

et al. 2007

Epilepsy & Behavior

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“…In support of this view, intellectual outcome is particularly poor if seizures begin prior to the age of five [5,[13][14][15][16][17], with the poorest outcomes associated with seizure onset in the first year of life [11,18]. The effect of age at onset persists once factors such as seizure control [14,19], number of antiepileptic drugs (AEDs) [19], etiology [20], duration of epilepsy [14,19,21], and extent of pathology are controlled [22], implying that developmental processes have an independent effect on cognitive outcome. Some recent studies have explored the relationship between age at seizure onset and specific cognitive functions across childhood.…”

Section: Introductionmentioning

confidence: 99%

Developmental stage affects cognition in children with recently-diagnosed symptomatic focal epilepsy

Gonzalez

Embuldeniya

Harvey

et al. 2014

Epilepsy & Behavior

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“…The onset of intractable epilepsy before the age of 2 years, especially when seizures occur daily, has been reported to be a risk factor for subsequent mental retardation [37]. Moreover, a shorter duration of frequent seizures before surgery may lead to a better long-term cognitive outcome [38].…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Patients with Rasmussen Encephalitis

Guan

Zhou

Luan

et al. 2014

Stereotact Funct Neurosurg

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Background: Rasmussen encephalitis (RE) is a rare progressive encephalitis that results in intractable seizures, cognitive decline and hemiparesis. Surgery seems to be the only effective way to control seizures in RE patients. Objective: To describe the clinical, electrophysiological, neuroradiological and histological findings of our patients with RE and to evaluate the outcome of their surgical treatment. Methods: A total of 20 patients were identified by the criteria of RE. Surgery was conducted in the left hemisphere in 6 patients and in the right hemisphere in 14. The surgical methods included anatomical hemispherectomy, functional hemispherectomy, hemispherotomy, lesion resection, multilobar resection, selective resection and bipolar electrocoagulation of functional cortexes. Results: The mean follow-up period was 5.45 years (range 3-8). After surgery, 16 patients (80%) were evaluated as being Engel class I. All of the patients had increases in cognitive abilities after surgery except 1 patient with bilateral RE. After surgery, most patients could walk independently, but the fine movement of the hands was lost. Postoperative hydrocephalus was observed in 1 patient after functional hemispherectomy, and there was no death in this series. Conclusion: Hemispherectomy and hemispherotomy were both confirmed as beneficial procedures in controlling seizures and improving quality of the life in RE cases.

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Mental Retardation in Pediatric Candidates for Epilepsy Surgery: The Role of Early Seizure Onset

Cited by 94 publications

References 29 publications

Academic performance in children with new-onset seizures and asthma: A prospective study

Academic performance in children with new-onset seizures and asthma: A prospective study

Developmental stage affects cognition in children with recently-diagnosed symptomatic focal epilepsy

Surgical Treatment of Patients with Rasmussen Encephalitis

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