Mentalizing impairment in schizophrenia: A functional MRI study

Das, Pritha; Lagopoulos, Jim; Coulston, Carissa; Henderson, Antony; Malhi, Gin S

doi:10.1016/j.schres.2011.08.019

Cited by 112 publications

(103 citation statements)

References 33 publications

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“…The increased modulation of activity within the bilateral inferior frontal gyri in patients with schizophrenia supports previous evidence of hyperactivation in frontal regions during social judgments (Mukherjee, et al, 2014). It is interesting to note that we found increased modulation of activation in regions including the left iFG and STG, previously found to be under-activated in schizophrenia using the same task (Das, Lagopoulos, et al, 2012). This is likely due to the explicit responding required in the current study, compared to the implicit nature of the task used previously.…”

Section: Left Inferior Frontal Gyrus (Ifg) Functional Connectivitysupporting

confidence: 88%

“…Regions activated during the physical animations (and random in SZ patients) included the right medial frontal gyrus and the left superior frontal gyrus. The inferior frontal gyri and left superior temporal gyrus involvement supports previous studies employing the Triangles Task (Das, Calhoun, et al, 2012;Das, Lagopoulos, et al, 2012) as well as results from a meta-analysis into similar mentalizing tasks (Schurz, Radua, Aichhorn, Richlan, & Perner, 2014).…”

Section: Left Inferior Frontal Gyrus (Ifg) Functional Connectivitysupporting

confidence: 86%

“…The Triangles Task (Castelli, et al, 2000) is a measure of mentalizing used in previous fMRI studies with patients with schizophrenia (Das, Calhoun, et al, 2012;Das, Lagopoulos, et al, 2012;Pedersen, et al, 2012). It involves viewing animations consisting of a large and small triangle interacting on a screen for a period of 36 seconds.…”

Section: Fmri Behavioural Task and Proceduresmentioning

confidence: 99%

“…Previous studies have not incorporated all conditions of the Triangles Task into the fMRI analyses (Das, Calhoun, et al, 2012;Das, Lagopoulos, Coulston, Henderson, & Malhi, 2012). Although contrasting the mental condition with the random condition may provide hints at the social brain network important for mentalizing, a more nuanced analysis should include the physical (or goaldirected) condition, as this controls for patterned or complex interaction without a mental component.…”

Section: Introductionmentioning

confidence: 99%

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Mentalizing in schizophrenia: A multivariate functional MRI study

et al. 2016

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Section: Left Inferior Frontal Gyrus (Ifg) Functional Connectivitysupporting

confidence: 88%

Section: Left Inferior Frontal Gyrus (Ifg) Functional Connectivitysupporting

confidence: 86%

Section: Fmri Behavioural Task and Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mentalizing in schizophrenia: A multivariate functional MRI study

et al. 2016

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“…In addition, patients with schizophrenia exhibit impairments in both basic sensory processing and higher cognitive functions, such as language, reasoning and planning [4]. Nowadays, there are some brain image systems helping to diagnose of schizophrenia, like structural MRI [5], diffusion MRI [6], functional MRI [7], PET [8], MEG [9] and SPECT [10] etc. However, the etiology and pathophysiology of schizophrenia remain unknown [2], while indeed, schizophrenia has come to be regarded more and more as a disease of disconnectivity [11].…”

Section: Introductionmentioning

confidence: 99%

A Review: Detecting Alterations of Brain Connectivity in Schizophrenia based on Structural MRI

Li¹

2014

J Psychiatry

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Schizophrenia is a common psychiatric disease with brain connectivity changed. Nowadays brain network has become an effective tool to detect the abnormal brain connectivity in patients. Compared with studies focused on functional and white matter connectivity, the research of grey matter connectivity is relatively less and should be paid more attention. The primary approach of grey matter connectivity analysis is based on brain network constructed from structural MRI (sMRI). There are several morphometric features such as cortical thickness, volume, and curvature etc. Which could be used for sMRI brain network construction? This review briefly introduced sMRI brain network construction and analysis, presenting the most frequently used morphometric features with their effectiveness in schizophrenia, highlighting the application of sMRI brain network in schizophrenia, and finally estimated its potential value.

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The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease

Wang

et al. 2021

Brain and Behavior

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Introduction: Degeneration changes of the basal forebrain (BF) are suggested to play an important role in cognitive impairment and memory loss in patients with Alzheimer's disease and Parkinson's disease. However, little is known about if and how the structure and function of BF are abnormal in Wilson's disease (WD).Methods: Here, we employed the structural and resting-state functional magnetic resonance imaging (fMRI) data from 19 WD individuals and 24 healthy controls (HC).Voxel-based morphometry (VBM) and functional connectivity analysis were applied to investigate the structural and functional degeneration changes of BF in WD. Moreover, the linear regression analyses were performed in the patient group to depict the correlations between the aberrant gray volume and functional connectivity of the BF and clinical performances, such as the prospective memory (PM) and mini-mental state examination (MMSE).Results: VBM analysis showed that compared with HC, the volume of overlapping cell groups of BF termed CH1-3 and CH4 was significantly reduced in WD. Additionally, the decreased functional connectivity of the CH4 was distributed in the bilateral temporal-parietal junction (TPJ), right thalamus, orbitofrontal gyrus (ORB), and left middle cingulate cortex (MCC). The performances of the time-based prospective memory (TBPM) and event-based prospective memory (EBPM) were related to reduced functional connectivity between CH4 and right ORB. Besides, the functional connectivity of left TPJ was also significantly correlated with EBPM in WD. Conclusion:These findings indicated that the degenerative changes of BF may affect PM through the innervation brain function and may help to understand the neural mechanisms underlying cognitive impairment in WD.

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Mentalizing impairment in schizophrenia: A functional MRI study

Cited by 112 publications

References 33 publications

Mentalizing in schizophrenia: A multivariate functional MRI study

Mentalizing in schizophrenia: A multivariate functional MRI study

A Review: Detecting Alterations of Brain Connectivity in Schizophrenia based on Structural MRI

The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease

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