Menthol and aspirin-induced asthma

Kawane, Hiroshi

doi:10.1016/s0954-6111(96)90300-5

Cited by 16 publications

(8 citation statements)

References 3 publications

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“…(2) described a patient with asthma triggered by menthol‐containing toothpaste. Since then some other cases were published referring to immediate hypersensitivity to mint or menthol, with different clinical presentation including urticaria, rhinitis and asthma (3–5). After performing challenges with menthol‐containing toothpaste, Kawane found a significant decrease in FEV 1 .…”

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confidence: 99%

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Toothpaste‐induced anaphylaxis caused by mint (Mentha) allergy

Paiva¹,

Piedade²,

Gáspár³

2010

Allergy

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confidence: 99%

“…The same test was performed in four patients with asthma but no menthol induced symptoms and the result was negative to all. Challenges were negative with menthol‐free toothpaste (3).…”

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confidence: 99%

Toothpaste‐induced anaphylaxis caused by mint (Mentha) allergy

Paiva¹,

Piedade²,

Gáspár³

2010

Allergy

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“…TRPM8 expression in the vagal neurons innervating bronchopulmonary tissue and its cold activation has recently been reported (Xing et al, 2008). Airway constriction could also be evoked by inhalation of menthol or peppermint oil vapor (Kawane, 1996;dos Santos et al, 2001). On the other hand, menthol is a well know anti-cough agent, and accordingly, it was shown to attenuate respiratory irritation responses to cigarette smoke irritants (Willis et al, 2011).…”

Section: Physiological Expression Patternmentioning

confidence: 99%

Regulation of TRPM8 channel activity

Yudin

Rohács

2012

Molecular and Cellular Endocrinology

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Transient Receptor Potential Melastatin 8 (TRPM8) is a Ca2+ permeable non-selective cation channel directly activated by cold temperatures and chemical agonists such as menthol. It is a well established sensor of environmental cold temperatures, found in peripheral sensory neurons, where its activation evokes depolarization and action potentials. The activity of TRPM8 is regulated by a number of cellular signaling pathways, most notably by phosphoinositides and the activation of phospholipase C. This review will summarize current knowledge on the physiological and pathophysiological roles of TRPM8 and its regulation by various intracellular messenger molecules and signaling pathways.

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“…The patient is now using menthol‐free products and his symptoms have abated. The patient also had a history of aspirin intolerance which might have increased his response (5).…”

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confidence: 99%