This study is an attempt to present a holistic Malay medicine practice covering the whole aspects of human life in terms of psychological, emotional, mental and physical. A clear relevance between Malay medicine and the Islamic medicine is also to be presented in this study. The method of treatment and practice of Malay medicine which are wanted to be highlighted in this study is an element have has been already presence in the Malay medical system ever since a long time ago and has continued to be practiced today. The treatment methods described in this study are such as life therapy, massage therapy, bath therapies, herbal therapies and also newborn care and postnatal care practices. However, Malay medicine emphasizes the prevention of disease through the practice of self-care in life therapy rather than the aspect of disease treatment. Hence, through research that has been increasingly done by researchers and academicians today is expected to further developing in Malay medicine knowledge so that it can be applied towards cure various diseases of society today.