Mercerization of tubular bacterial nanocellulose for control of the size and performance of small-caliber vascular grafts

Hu, Gaoquan; Chen, Lin; Zhao, Sheng‐Yin; Hong, Feng

doi:10.1016/j.cej.2021.131104

Cited by 29 publications

(27 citation statements)

References 56 publications

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“…The difference in the surface chemical structure of HA, BNC, and BNC/HA composite membranes was determined by FT-IR, as shown in Figure . In the spectrum of BNC, the characteristic peaks were observed at 3345.40, 2869.88, 1161.18, and 1055.42 cm –1 , representing the (−OH) vibration, the (−CH) stretching vibration, the cellulose glycoside chain, and the (C–O) stretching vibration, respectively . The characteristic peaks of the pure HA samples were found at 1621.78, 1433.98, and 1033.34 cm –1 .…”

Section: Resultsmentioning

confidence: 97%

“…Bacterial nanocellulose (BNC) is a natural polymer mainly produced by Komagataeibacter xylinus (formerly Gluconacetobacter xylinus and Acetobacter xylinum) at the gas–liquid interface. BNC has a nanoscale three-dimensional fibrous network structure, high hydrophilicity, excellent mechanical properties, and good biocompatibility, which have enabled it to attract wide attention in biomedical applications, such as small caliber artificial vessels , and wound dressings. − In addition, BNC has a certain degree of flexibility and transparency, which offers great potential in corneal transplantation and ocular surface repair. The shape of BNC is controllable and has a certain degree of compliance, which enables BNC to adhere to the eye surface and adapt to is dome shape .…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Evaluation of Bacterial Nanocellulose/Hyaluronic Acid Composite Artificial Cornea for Application of Corneal Transplantation

Luo

Chen

et al. 2022

Biomacromolecules

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The treatment for corneal damage requires donor corneal transplantation, but there is a serious scarcity of donor corneas worldwide. In this study, we aimed to design a new artificial cornea with good cytocompatibility, excellent optical properties and suture resistance, and great moisturizing properties. A new bacterial nanocellulose (BNC) membrane with anisotropic mechanical properties and high light transmission was produced in a horizontal rotary drum reactor. However, as a potential material for artificial keratoplasty, the transparency and mechanical properties of the new BNC membrane were not satisfactory. Thus, hyaluronic acid (HA) was introduced in the BNC to synthesize the BNC/HA composite membrane by using 1,4-butanediol diglycidyl ether (BDDE) as the chemical cross-linking agent. The micro-morphology, light transmittance, mechanical properties, water content, moisture retention ability, and cytocompatibility of the composite membranes were further evaluated. HA was fixed in the BNC network by the ether bond, and the composite membrane was found to have excellent light transmittance (up to 95.96%). The composite membrane showed excellent mechanical properties, for instance, its tensile strength exceeded the human normal intraocular pressure (IOP) (1.33–2.80 kPa), the maximum burst pressure was about 130 kPa, 46–97 times that of the normal IOP, and its suture force was close to that of the human amniotic membrane (0.1 N). Based on the three-dimensional network scaffold of BNC and the high water absorption characteristics of HA, the artificial cornea had high water content and high moisture retention ability. The rabbit corneal stromal cells cultured in vitro showed that the artificial cornea substitute had excellent cytocompatibility. BDDE is the most frequently used cross-linker in most HA products in the current cosmetic medicine industry owing to its long-term safety records for over 15 years. Therefore, the BNC/HA composite hydrogel cross-linked with BDDE has great potential in artificial keratoplasty or ocular surface repair.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Bacterial Nanocellulose/Hyaluronic Acid Composite Artificial Cornea for Application of Corneal Transplantation

Luo

Chen

et al. 2022

Biomacromolecules

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“…By integrating chitosan nanoparticles (CSNPs) into a BNC matrix using an ionic gelation technique and with no cross-linking agents or dispersants (that is, eco-design), a composite CSNPs-BNC with impressive antibacterial activity capable of promoting the adhesion and proliferation of Schwann cells, with high biocompatibility and impressive in vitro and in vivo conclusions toward a sustainable NGC conduit is reported . An emerging possibility for BNCs to be used as candidates for blood vessel replacement is reported . The possibility of using the mercerization process on tubular BNCs to effectively control their properties and enhance performance in small-caliber vascular grafts is a testament to the possibilities green(er) material technology presents to humanity .…”

Section: Applicationsmentioning

confidence: 99%

“… 126 An emerging possibility for BNCs to be used as candidates for blood vessel replacement is reported. 127 The possibility of using the mercerization process on tubular BNCs to effectively control their properties and enhance performance in small-caliber vascular grafts is a testament to the possibilities green(er) material technology presents to humanity. 127 Cardiovascular diseases (CVDs) rank top among the major contributors to global mortality and disability.…”

Section: Applicationsmentioning

confidence: 99%

Nanocellulosics in Transient Technology

Iroegbu

Ray

2022

ACS Omega

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Envisage a world where discarded electrical/electronic devices and single-use consumables can dematerialize and lapse into the environment after the end-of-useful life without constituting health and environmental burdens. As available resources are consumed and human activities build up wastes, there is an urgency for the consolidation of efforts and strategies in meeting current materials needs while assuaging the concomitant negative impacts of conventional materials exploration, usage, and disposal. Hence, the emerging field of transient technology (Green Technology), rooted in eco-design and closing the material loop toward a friendlier and sustainable materials system, holds enormous possibilities for assuaging current challenges in materials usage and disposability. The core requirements for transient materials are anchored on meeting multicomponent functionality, low-cost production, simplicity in disposability, flexibility in materials fabrication and design, biodegradability, biocompatibility, and environmental benignity. In this regard, biorenewables such as cellulose-based materials have demonstrated capacity as promising platforms to fabricate scalable, renewable, greener, and efficient materials and devices such as membranes, sensors, display units (for example, OLEDs), and so on. This work critically reviews the recent progress of nanocellulosic materials in transient technologies toward mitigating current environmental challenges resulting from traditional material exploration, usage, and disposal. While spotlighting important fundamental properties and functions in the material selection toward practicability and identifying current difficulties, we propose crucial research directions in advancing transient technology and cellulose-based materials in closing the loop for conventional materials and sustainability.

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“…Some animal experiments have also shown that BNC tubes do not produce a significant inflammatory reaction [ 8 ]. However, some properties of BNC tubes do not satisfactorily achieve the demands of clinical application as artificial blood vessels, such as mechanical properties in a hydrogel state, anticoagulation biocompatibility and other characteristics [ 12 , 13 ]. Therefore, BNC must be modified to better satisfy these requirements as an artificial blood vessel material.…”

Section: Introductionmentioning

confidence: 99%

Potential of a Composite Conduit with Bacterial Nanocellulose and Fish Gelatin for Application as Small-Diameter Artificial Blood Vessel

Bao

Tang

et al. 2022

Polymers

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Bacterial nanocellulose (BNC) has received great attention for application as an artificial blood vessel material. However, many results showed that pristine BNC could not perfectly meet all the demands of blood vessels, especially for rapid endothelialization. In order to improve the properties of small-caliber vessels, different concentrations of fish gelatin (Gel) were deposited into the 3D network tubes and their properties were explored. The BNC/Gel composite tubes were treated with glutaraldehyde to crosslink BNC and fish gelatin. Compared with pristine BNC tubes, the BNC/Gel tubes had a certain improvement in mechanical properties. In vitro cell culture demonstrated that the human endothelial cells (HUVECs) and human smooth muscle cells (HSMCs) planted on the internal walls of BNC/Gel tubes showed better adhesion, higher proliferation and differentiation potential, and a better anticoagulation property, as compared to the cells cultured on pristine BNC tubes. Whole-blood coagulation experiments showed that the BNC/Gel tube had better properties than the BNC tube, and the hemolysis rate of all samples was less than 1.0%, satisfying the international standards for medical materials. An increase in the content of fish gelatin also increased the mechanical properties and the biocompatibility of small-caliber vessels. Considering the properties of BNC/Gel tubes, 1.0 wt/v% was selected as the most appropriate concentration of fish gelatin for a composite.

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Mercerization of tubular bacterial nanocellulose for control of the size and performance of small-caliber vascular grafts

Cited by 29 publications

References 56 publications

Preparation and Evaluation of Bacterial Nanocellulose/Hyaluronic Acid Composite Artificial Cornea for Application of Corneal Transplantation

Preparation and Evaluation of Bacterial Nanocellulose/Hyaluronic Acid Composite Artificial Cornea for Application of Corneal Transplantation

Nanocellulosics in Transient Technology

Potential of a Composite Conduit with Bacterial Nanocellulose and Fish Gelatin for Application as Small-Diameter Artificial Blood Vessel

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