Mercury exposure and oxidative stress in communities of the Brazilian Amazon

Grotto, Denise; Valentini, Juliana; Fillion, Myriam; Passos, Carlos José Sousa; Garcia, Solange Cristina; Mergler, Donna; Barbosa, Fernando

doi:10.1016/j.scitotenv.2009.10.053

Cited by 116 publications

(78 citation statements)

References 58 publications

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“…A cross-sectional study included 135 adult volunteers recruited from 12 fish-eating communities in the Brazilian Amazon had the objective to examine possible relations between different biomarkers of mercury exposure and oxidative stress using linear regression (Grotto et al, 2010). Medians of mercury were in blood 40.5 µg/L (range 1.70 to 179.3), in plasma 4.7 µg/L (0.2 to 30.9), and in hair 10.1 mg/kg (1.0 to 57.8).…”

Section: Miscellaneousmentioning

confidence: 99%

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

2012

EFS2

463

160

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EFSA was asked by the European Commission to consider new developments regarding inorganic mercury and methylmercury toxicity and evaluate whether the Joint FAO/WHO Expert Committee on Food Additives (JECFA) provisional tolerable weekly intakes for methylmercury of 1.6 µg/kg body weight (b.w.) and of 4 µg/kg b.w. for inorganic mercury were still appropriate. In line with JECFA, the CONTAM Panel established a tolerable weekly intake (TWI) for inorganic mercury of 4 µg/kg b.w., expressed as mercury. For methylmercury, new developments in epidemiological studies from the Seychelles Child Developmental Study Nutrition Cohort have indicated that n-3 long-chain polyunsaturated fatty acids in fish may counteract negative effects from methylmercury exposure. Together with the information that beneficial nutrients in fish may have confounded previous adverse outcomes in child cohort studies from the Faroe Islands, the Panel established a TWI for methylmercury of 1.3 µg/kg b.w., expressed as mercury. The mean dietary exposure across age groups does not exceed the TWI for methylmercury, with the exception of toddlers and other children in some surveys. The 95 th percentile dietary exposure is close to or above the TWI for all age groups. High fish consumers, which might include pregnant women, may exceed the TWI by up to approximately six-fold. Unborn children constitute the most vulnerable group. Biomonitoring data from blood and hair indicate that methylmercury exposure is generally below the TWI in Europe, but higher levels are also observed. Exposure to methylmercury above the TWI is of concern. If measures to reduce methylmercury exposure are considered, the potential beneficial effects of fish consumption should also be taken into account. Dietary inorganic mercury exposure in Europe does not exceed the TWI, but inhalation exposure of elemental mercury from dental amalgam is likely to increase the internal inorganic mercury exposure; thus the TWI might be exceeded. This opinion focuses only on the risks related to dietary inorganic mercury and methylmercury exposure and does not assess the nutritional benefits linked to certain foods (e.g. fish and other seafood).A call for annual collection of chemical contaminant occurrence data in food and feed, including mercury, was issued by EFSA in December 2010. In response, EFSA received 59 820 results on mercury in food from 20 European countries, mainly covering the period from 2004 to 2011. A total number of 59 650 results were described with sufficient detail to be used in the statistical analysis of the respective food groups; 98.2 % of the samples were for total mercury, 1.8 % for methylmercury and three samples for inorganic mercury.All the 20 food groups available at the first level of FoodEx were covered in the current data collection. The food groups 'Fish and other seafood' and 'Meat and meat products' dominated the food product coverage with 36.8 % and 17.6 % respectively. These were followed by 'Grain and grain-based products' at 7.8 % and 'Vegetables an...

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Section: Miscellaneousmentioning

confidence: 99%

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

2012

EFS2

463

160

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“…As concentrações de Hg sanguíneo observadas nos voluntários avaliados nas três comunidades do presente estudo é concordante com outros estudos na região do Rio Tapajós (AKAGI et al, 1995;GROTTO et al, 2010;LEBEL et al, 1998;PASSOS et al, 2007a;2007b). A principal fonte de exposição a esse metal tóxico para a maioria dos habitantes da região amazônica, incluindo os provenientes do Tapajós, está no consumo de peixe (BARBOSA; GARCIA; SOUZA, 1997;BASTOS et al, 2006;DE OLIVEIRA SANTOS et al, 2002;DOLBEC et al, 2000DOLBEC et al, , 2001GROTTO et al, 2011b;MALM et al, 1990MALM et al, , 1995MALM et al, , 2010MAURICE-BOURGOIN et al, 2000;PALHETA;TAYLOR, 1995;PASSOS;MERGLER, 2008;PINHEIRO et al, 2000PINHEIRO et al, , 2006.…”

Section: Discussionunclassified

“…Posteriormente, foi investigado o possível efeito modulador dos micronutrientes também provenientes da dieta alimentar e das características sociais e demográficas sob os biomarcadores de estresse oxidativo e Hg-S. , 1998;BULAT et al, 1998;CHEN et al, 2005;GROTTO et al, 2010GROTTO et al, , 2011aHUSSAIN et al, 1999;PINHEIRO et al, 2008). (DA SILVA et al, 2007;PEROTTONI et al, 2004;VALENTINI et al, 2007VALENTINI et al, , 2008VALENTINI et al, , 2009.…”

Section: Discussionunclassified

“…(DA SILVA et al, 2007;PEROTTONI et al, 2004;VALENTINI et al, 2007VALENTINI et al, , 2008VALENTINI et al, , 2009. Estudos com animais mostraram inibição da atividade da mesma após a exposição ao Hg (AUGUSTI et al, 2007(AUGUSTI et al, , 2008FARINA et al, 2004;NOGUEIRA et al, 2003;VALENTINI et al, 2009) A reativação da ALA-D pode ser usada em estudos clínicos e epidemiológicos para avaliar a ação da condição oxidante crônica sobre os grupos -SH da enzima (GONÇALVES et al, 2005;GROTTO et al, 2010;VALENTINI et al, 2007VALENTINI et al, , 2008 O processo inflamatório crônico está envolvido em distúrbios que envolvem o sistema cardiovascular (LIUZZO et al, 1994, RIDKER et al, 2000. Ademais, alterações nesse sistema estão associados com a exposição ao Hg (DE MARCO et al, 2010;FILLION et al, 2006;GUALLAR et al, 2002;MOZAFFARIAN, 2009;RISSANEN et al, 2000;VIRTANEN et al, 2005).…”

Section: Discussionunclassified

“…O desequilíbrio entre antioxidantes e pró-oxidantes pode levar aos mais diversos danos celulares, desencadeando alterações progressivas em proteínas, lipídios, açúcares e DNA, reduzindo sua capacidade funcional e aumentando o risco ao desenvolvimento de doenças (BERR, 1998;FINKEL;HOLBROOK, 2000). (AUGUSTI et al, 2007(AUGUSTI et al, , 2008FARINA et al, 2004;GROTTO et al, 2010;NOGUEIRA et al, 2003;PEROTTONI et al, 2004;VALENTINI et al, 2007VALENTINI et al, , 2008). …”

Section: Estresse Oxidativo E Mehgunclassified

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Cited by 116 publications

References 58 publications

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

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Influence of fish consumption and some of its individual constituents on oxidative stress in cells, animals, and humans

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