Mercury in Biological Fluids after Amalgam Removal

Sandborgh‐Englund, Gunilla; Elinder, Carl‐Gustaf; Langworth, Sven; Schütz, Andrejs; Ekstrand, Jan

doi:10.1177/00220345980770041501

Cited by 85 publications

(52 citation statements)

References 33 publications

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“…In the two groups without amalgam fillings, the concentrations before DMPS injection and the amounts of mercury excreted after DMPS injection were about one-third of those in the groups with amalgam. This finding confirms that amalgam fillings are a significant source of mercury exposure and that removing amalgam fillings reduces the exposure Herrmann and Schweinsberg, 1993;Sandborgh-Englund et al, 1998).…”

Section: Discussionsupporting

confidence: 59%

Diagnostic Value of a Chelating Agent in Patients with Symptoms Allegedly Caused by Amalgam Fillings

Vamnes

Eide

Isrenn³

et al. 2000

J Dent Res

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The chelating agent 2,3 dimercaptopropane-1-sulfonate (DMPS) has been used in a mercury mobilization test for diagnoses in illnesses allegedly associated with the presence of amalgam restorations. DMPS is an accepted antidote to heavy metal poisoning. The aim of the present study was to evaluate the diagnostic value of DMPS in patients with symptoms self-related to their amalgam fillings. The subjects consisted of four groups: 19 healthy controls without amalgam experience; 21 healthy controls with amalgam fillings; 20 patients who claimed symptoms of "mercury poisoning" from dental amalgam; and 20 patients who had amalgam fillings removed because of such symptoms. DMPS (2 mg/kg body weight) was injected intravenously, and urine was collected prior to the injection, 30 and 120 min after the injection, and throughout the next 22 hrs. The samples were analyzed for total mercury by cold vapor atomic absorption spectrophotometry. The total median amounts of mercury excreted over 24 hrs for those with complaints allegedly associated with amalgam and for the healthy controls with amalgam fillings were similar. Persons with amalgam fillings excreted about three times more mercury than those without. The controls, who had never had amalgam fillings, and the subjects who had had their fillings removed excreted median amounts of 8.5 microg and 7.2 microg mercury, respectively. The present DMPS challenge test did not differentiate between patients with or those without complaints self-related to their amalgam fillings but did confirm the higher mercury values in patients with dental amalgam.

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Section: Discussionsupporting

confidence: 59%

Diagnostic Value of a Chelating Agent in Patients with Symptoms Allegedly Caused by Amalgam Fillings

Vamnes

Eide

Isrenn³

et al. 2000

J Dent Res

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“…The determination of total mercury (inorganic Hg + organic Hg) was made in acid-digested samples by cold vapor atomic fluorescence spectrometry [21] . The limit of detection calculated as 3 times the SD for the blanks was 0.21 g/l.…”

Section: Metal Analysismentioning

confidence: 99%

Metal Concentrations in Plasma and Cerebrospinal Fluid in Patients with Alzheimer’s Disease

Gerhardsson

Lundh²,

Minthon³

et al. 2008

Dement Geriatr Cogn Disord

183

110

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Background/Aims: The homeostasis of essential metals such as copper, iron, selenium and zinc may be altered in the brain of subjects with Alzheimer’s disease (AD). Methods: Concentrations of metals (magnesium, calcium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, tin, antimony, cesium, mercury and lead) were determined in plasma and cerebrospinal fluid (CSF) by inductively coupled plasma mass spectrometry in 173 patients with AD and in 87 patients with the combination of AD and minor vascular components (AD + vasc). Comparison was made with 54 healthy controls. Results: The plasma concentrations of manganese and total mercury were significantly higher in subjects with AD (p < 0.001) and AD + vasc (p ≤ 0.013) than in controls. In CSF, however, the concentrations of vanadium, manganese, rubidium, antimony, cesium and lead were significantly lower among subjects with AD (p ≤ 0.010) and AD + vasc (p ≤ 0.047) than in controls. Strong positive correlations were noted between plasma Cs versus CSF Cs in subjects with AD (r_s = 0.50; p < 0.001), and AD + vasc (r_s = 0.68; p < 0.001). Conclusion: Besides the raised plasma mercury concentrations, no consistent metal pattern in plasma or CSF was observed in patients with AD.

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“…Maternal exposure to MeHg during pregnancy was associated with psychomotor retardation, defects in attention, and motor dysfunction in multiple ethnic groups (Halbach et al 2008;Sandborgh-Englund et al 1998). In addition, both higher blood Hg concentrations and increased maternal fish consumption in the second trimester were associated with lower scores in cognitive and visual abilities among children in a US prospective cohort study (Oken et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Mercury health risk assessment among a young adult Lebanese population

Obeid

Fares

Farhat

et al. 2017

Environ Sci Pollut Res

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Mercury (Hg) exposure represents a significant public health concern at a global level. This study aims at assessing Hg exposure and risk among Lebanese young adults based on Hg biomonitoring and seafood intake. A group of 166 young adults were administered a questionnaire to assess Hg exposure and were asked to provide a hair sample. Risk assessment was performed: (1) using the US Environmental Protection Agency Hazard Quotient (HQ) model based on fish intake and previously studied local fish Hg concentrations, and (2) by determining the total hair Hg concentration (THHg) using continuous flow-chemical vapor generation atomic absorption spectrometry. Differences in THHg across demographic and exposure subgroups were tested using t test or ANOVA. Correlations between THHg concentrations, fish consumption, and HQ were determined by computing Pearson's r. Higher THHg correlated with higher consumption of Mediterranean rabbitfish/spinefoots (r = 0.27; p = 0.001) and geographical location (p < 0.001) in the bivariate analysis, and remained significant in the adjusted multivariable linear regression model (geographical location: ß = 0.255, 95%CI 0.121-0.388; rabbitfish/spinefoots consumption: ß = 0.016, 95%CI 0.004-0.027). No significant correlations were found between HQ and THHg. In conclusion, this is the first study examining hair Hg levels and fish consumption in a young adult Lebanese population. Our findings constitute valuable baseline data for a local fish advisory and Hg monitoring.

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Mercury in Biological Fluids after Amalgam Removal

Cited by 85 publications

References 33 publications

Diagnostic Value of a Chelating Agent in Patients with Symptoms Allegedly Caused by Amalgam Fillings

Diagnostic Value of a Chelating Agent in Patients with Symptoms Allegedly Caused by Amalgam Fillings

Metal Concentrations in Plasma and Cerebrospinal Fluid in Patients with Alzheimer’s Disease

Mercury health risk assessment among a young adult Lebanese population

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