Mercury-induced Oxidative Stress May Adversely Affect Pregnancy Outcome among Dental Staff: A Cohort Study

Elbadry, Aziza Saad; Rezk, Mohamed; Elsayed, Hanan

doi:10.15171/ijoem.2018.1181

Cited by 36 publications

(24 citation statements)

References 20 publications

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“…Spontaneous resorption is a major problem in assisted reproduction in humans (Drews et al 2020). Findings from the present study suggest that exposure of blastocysts to nanomolar concentrations (10-200 nM) of MeHg, if it occurs in vivo, could disrupt early embryo development, implantation, and postimplantation development: outcomes that could explain the positive association between urinary mercury concentrations, oxidative stress, and spontaneous abortion observed in pregnant dental staff in Egypt (El-Badry et al 2018). Monitoring blood and hair mercury concentrations during the preconception period to minimize the risk of adverse pregnancy outcomes has been practiced in the Hospital for Sick Children in Toronto, Canada (Neuman et al 2014).…”

Section: Discussionmentioning

confidence: 61%

“…2020 ). Findings from the present study suggest that exposure of blastocysts to nanomolar concentrations (

) of MeHg, if it occurs in vivo , could disrupt early embryo development, implantation, and postimplantation development: outcomes that could explain the positive association between urinary mercury concentrations, oxidative stress, and spontaneous abortion observed in pregnant dental staff in Egypt ( El-Badry et al. 2018 ).…”

Section: Discussionmentioning

confidence: 73%

See 1 more Smart Citation

Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells

Bai

Qiao

Jin

et al. 2021

Environ Health Perspect

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Background: Global concerns of methylmercury (MeHg) exposure have been raised, especially on its effects on pregnant women. Recent epidemiological studies have revealed associations between maternal blood/hair MeHg concentrations, adverse pregnancy outcomes, and developmental deficits. However, the underlying mechanisms remain unclear. Objectives: In this study, we characterized the effects of MeHg exposure on undifferentiated human embryonic stem cells (hESCs) and extrapolated the effects to human embryonic development. Methods: hESCs were exposed to 0, 1, 5, 10, 50, 100 or MeHg for 24 h or 6 d. Cell adherence and colony formation and expansion were examined under the microscope. Cell attachment, viability/proliferation, apoptosis, stress response, cell cycle, autophagy, and expression of cell lineage marker genes and proteins were measured at the end of exposures. Results: Our results indicated that exposure to nanomolar concentrations of MeHg was associated with a ) higher levels of reactive oxygen species (ROS) and hemeoxygenase-1 (HO-1), suggesting increased stress and adaptive responses; b ) lower cellular adhesion, viability/proliferation, and colony formation and expansion; c ) higher levels of apoptosis, reflected by higher cleaved caspase-3 expression and Annexin V binding; d ) higher levels of cytoskeleton protein expression; e ) higher rates of G1/S phase cell cycle arrest; and f ) autophagy inhibition, as shown by a lower LC3BII/LC3BI ratio and accumulation of SQSTM1 (p62). These outcomes were accompanied by higher expressions of self-renewal genes or proteins or both, including OCT4, SOX2, NANOG, and cytokine receptor IL6ST, as well as pluripotency and the cell fate regulator cyclin D1. Discussion: These results revealed that under the selection pressure of exposure to low doses of MeHg, some hESCs underwent apoptosis, whereas others adapted and survived with enhanced self-renewal gene expression and specific morphological phenotypes. Findings from the present study provide in vitro evidence that low doses of MeHg adversely affect hESCs when exposed during a period of time that models embryonic pre-, during, and early postimplantation stages. https://doi.org/10.1289/EHP7349

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Section: Discussionmentioning

confidence: 61%

“…2020 ). Findings from the present study suggest that exposure of blastocysts to nanomolar concentrations (

Section: Discussionmentioning

confidence: 73%

Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells

Bai

Qiao

Jin

et al. 2021

Environ Health Perspect

View full text Add to dashboard Cite

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“…They also linked irregular menstrual cycles as an effect of exposure. Dysmenorrhea and abdominal pain were also described as symptoms of mercury exposure [ 124 ]. Lead was found to have similar fertility negative effects.…”

Section: Trace Elements and Its Role In The Diseasesmentioning

confidence: 99%

Brief Review of Endometriosis and the Role of Trace Elements

Osuchowska-Grochowska

Blicharska

Gogacz

et al. 2021

IJMS

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Endometriosis is a chronic, estrogen-dependent, inflammatory condition that is defined as the presence of endometrial glands and stroma outside the uterine cavity. Despite the progress in research into the mechanisms leading to the development of endometriosis, its cause has not yet been established. It seems to be possible that the formation of oxidative stress may be one of the main causes of the development of endometriosis. There is much research that studies the potential role of trace elements in the appearance of endometrial-like lesions. Most studies focus on assessing the content of selected trace elements in the blood, urine, or peritoneal fluid in women with endometriosis. Meanwhile, little is known about the content of these elements in endometrial-like implants, which may be helpful in developing the theory of endometriosis. Investigations that are more comprehensive are needed to confirm a hypothesis that some trace elements play a role in the pathomechanism of endometriosis.

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“…Although need of largescale studies in human is required. [12][13][14][15][16][17] Aims and Objectives: The present study was undertaken in the Department of Biochemistry…”

Section: Pregnancy Specific Complication Characterisedmentioning

confidence: 99%

Effect of Minerals on Markers of Risk of Pre-Eclampsia in Pregnant Women: A Hospital Based Study

2020

IJFMT

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Introduction: Pregnancy specific complication characterised by hypertension, proteinuria, after 20 weeks of the gestation, and along with various signs of damage to organ systems, haemolysis, elevated levels of liver enzymes and low platelet count (HELLP syndrome) is collectively termed as eclampsia.Method: Cross-sectional study with 3 groups of pregnant women, were taken followed by inclusion and exclusion criteria for characterisation. The study was approved by ethical board of DMIMSU. Minerals and their relationship were estimated using different method. Preeclamptic group with and without supplementation and pregnant women without preeclampsia were included in the study. Significant differences were seen in Na+, K+, Ca, Mg, Se, and Mn when compared with each group. Result and Observation:The levels of K were increased significantly (P < 0.001) in pre-eclamptic group as compared to control group. There was significant change in levels of Mn when pre-eclamptic group was compared to control. Mn was also found to decrease significantly (P < 0.001) in cases as compared to control. However, the levels of Se, Mg, Ca and Na between cases and control were not highly significant. In supplementation and without supplementation group, Significant differences were seen in levels of Na, K, Ca and very significant difference was seen in levels of Mn. (p<0.0001). Conclusion:Pre-eclamptic pregnant women have higher levels of serum potassium and our finding on Mn, an essential trace mineral, provides new insight into a potentially modifiable way to prevent preeclampsia. In multi-ethnic, predominantly urban and low-income pregnant women high level of Mn is associated with pre-eclampsia.

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Mercury-induced Oxidative Stress May Adversely Affect Pregnancy Outcome among Dental Staff: A Cohort Study

Cited by 36 publications

References 20 publications

Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells

Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells

Brief Review of Endometriosis and the Role of Trace Elements

Effect of Minerals on Markers of Risk of Pre-Eclampsia in Pregnant Women: A Hospital Based Study

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