Merkel Cell Carcinoma of the Genitourinary Tract

Aron, Manju; Zhou, Ming

doi:10.5858/2010-0072-rsr2

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…Paranuclear dot positivity for CK20 and CAM5.2 is a typical feature of MCC [17]. MCC is also positive for CK AE1/AE3 and neuroendocrine markers, synaptophysin, and chromogranin.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Merkel cell carcinoma of the testis with unknown primary site: a case report

2016

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BackgroundMerkel cell carcinoma is a rare and aggressive neuroendocrine tumor that commonly arises in the skin. It is rare for it to occur in the testes. There are only seven cases of testicular Merkel cell carcinoma reported in the literature.Case presentationA 66-year-old Maori man presented to our hospital with left testicular swelling. His alpha-fetoprotein and beta-human chorionic gonadotrophin levels were within normal limits. His lactate dehydrogenase concentration was elevated to 267 U/L. Ultrasound imaging confirmed a large testicular mass, and he underwent left orchiectomy. His histological examination revealed a neuroendocrine tumor with an immunostaining pattern suggesting Merkel cell carcinoma. He presented to our hospital again 3 months later with right testicular swelling that was confirmed on ultrasound sonography to be a tumor. He underwent a right orchiectomy, and his histological examination revealed metastatic Merkel cell carcinoma. A primary lesion was not identified, and computed tomographic imaging did not reveal spread to other organs. He received six cycles of adjuvant carboplatin and etoposide chemotherapy and remained disease-free 18 months after completion of chemotherapy.ConclusionsGiven the paucity of studies, standard adjuvant treatment for testicular Merkel cell carcinoma remains uncertain, although platinum-based chemotherapy seems to be an appropriate option.Electronic supplementary materialThe online version of this article (doi:10.1186/s13256-016-1102-5) contains supplementary material, which is available to authorized users.

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“…Paranuclear dot positivity for CK20 and CAM5.2 is a typical feature of MCC [17]. MCC is also positive for CK AE1/AE3 and neuroendocrine markers, synaptophysin, and chromogranin.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Merkel cell carcinoma of the testis with unknown primary site: a case report

2016

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“… 1 Although some cutaneous MCCs were reported to be associated with squamous cell carcinomas (SCCs), such combined cases accounted for only a minor portion and the viral status appeared to be different from pure MCC. 1 , 2 , 3 , 4 Rarely, primary MCCs occur on the female vulva, 5 with or without combined SCCs, 6 , 7 the latter is often human papillomavirus (HPV) related.…”

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confidence: 99%