Merkel cell carcinoma of the lower lip: A case report and literature review

Arruda, José Alcides Almeida de; Mesquita, Ricardo Alves; Canêdo, Nathalie Henriques Silva; Agostini, Michelle; Abrahão, Aline Corrêa; Andrade, Bruno Augusto Benevenuto De; Romañach, Mário José

doi:10.1016/j.oraloncology.2020.105019

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…The most relevant of the possible diagnoses are acinar cell carcinoma and adenoid cystic or ceruminous carcinoma, especially when they present a diffuse or basaloid histologic pattern. Likewise, Merkel cell carcinoma presents rounded cells with elevated nucleus-to-cytoplasm ratio and hyperchromatic nuclei with a stippled or “salt-and-pepper” condensed chromatin pattern [11] that can resemble promyelocytes forming the GS (shown in Fig. 2c).…”

Section: Discussionmentioning

confidence: 99%

Granulocytic Sarcoma Mimicking Cholesteatoma: Beware the Temporal Bone in Haematological Patients

Mayani-Mayani,

González-Arnay,

Acosta-Criado

et al. 2023

ORL

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Granulocytic sarcoma is a myeloid neoplasm that can occur in isolation or in association with acute leukaemia. The temporal bone represents a sanctuary site for myeloid progenitors: granulocytic sarcoma may develop in this location before or concomitantly with the onset of acute leukaemia. This atypical presentation with clinical and radiological data that closely mimic those of cholesteatoma often delays an accurate diagnosis. We here describe the clinical case of a 28-year-old male with granulocytic sarcoma of the external auditory canal that preceded the relapse of promyelocytic leukaemia.

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Section: Discussionmentioning

confidence: 99%

Granulocytic Sarcoma Mimicking Cholesteatoma: Beware the Temporal Bone in Haematological Patients

Mayani-Mayani,

González-Arnay,

Acosta-Criado

et al. 2023

ORL

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Merkel cell carcinoma – Time to consider personalized medicine and combinatorial therapeutic strategies

Parthasarathy¹

2022

Oral Oncology

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Merkel cell: Friend or felon

Tandon,

Singh,

Gulati

2024

Journal of Oral and Maxillofacial Pathology

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Merkel cells are perceived as tactile receptors within skin and oral mucosa containing abundant intermediate filaments but lacking characteristic condensation of tonofilaments, hence are also referred to as non-keratinocytes. Merkel cell carcinomas (MCCs) are primary aggressive neuroendocrine neoplasms occurring in elderly individuals. Toker in 1972 reported MCC of skin pointing towards sweat glands as the source of origin which was later rectified by Tang with the aid of ultrastructural studies as Merkel cells to be a lineage of such tumours. Normally, Merkel cells are abundant in the gingiva and vermillion border of the lip and thus these are the common sites for this neoplasm. Histopathologically, MCC mimics varied other carcinomas, hence requiring a thorough diagnostic protocol. We present a case of challenging histopathology which on immunohistochemical analysis with a unique cytokeratin profile and neurofilament staining pattern helped in reaching a definitive diagnosis.

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Merkel cell carcinoma of the lower lip: A case report and literature review

Cited by 4 publications

References 27 publications

Granulocytic Sarcoma Mimicking Cholesteatoma: Beware the Temporal Bone in Haematological Patients

Granulocytic Sarcoma Mimicking Cholesteatoma: Beware the Temporal Bone in Haematological Patients

Merkel cell carcinoma – Time to consider personalized medicine and combinatorial therapeutic strategies

Merkel cell: Friend or felon

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