Merkel Cell Tumor of the Eyelid: A Review and Report of an Unusual Case

Abstract

We describe a case of a Merkel cell tumor of the eyelid that manifested as a recurrent chalazion. This tumor had the classic characteristics of a Merkel cell neoplasm by light microscopy. Electron microscopy showed dense-core neurosecretory granules and perinuclear microfilaments consistent with the diagnosis. Because a Merkel cell tumor may manifest as a chalazion, pathologic evaluation of all atypical chalazia is essential. Merkel cell tumors are malignant, and they must be treated aggressively to minimize recurrence or metastasis.

Spinal metastasis from merkel cell carcinoma in an elderly male

“…Indeed, studies have shown as much as 14% of those with nodal disease to have no associated cutaneous finding. [7,8,10,11,13,14] With MCC's lack of distinctive characteristics and assorted presentations, clinical suspicion is often underutilized. That is why past studies have suggested the use of the AEIOU system -asymptomatic/lack of tenderness, expanding rapidly, immune suppression, older than 50 years of age, and ultraviolet (UV) exposure-for initial evaluation.…”

“…[1] Although variations of the cutaneous manifestations of MCC include pedunculated masses, chalazions, and granulation tissue. [10][11][12] The incidence in the United States is projected around 1500 cases each year [2] with increases seen, in part, to diagnostic and staining techniques. Even with early recognition, MCC has a dismal prognosis given the high rate of recurrence and early metastasis.…”