Merkel cells are responsible for the initiation of taste organ morphogenesis in the frog

Toyoshima, Kuniaki; Seta, Yuji; Toyono, Takashi; Takeda, Shinobu

doi:10.1002/(sici)1096-9861(19990329)406:1<129::aid-cne8>3.0.co;2-p

Cited by 15 publications

(14 citation statements)

References 57 publications

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“…; Viertel ; Żuwała , ; Toyoshima et al . ). At stage TS 15 and in hatchlings, the tongue fold of E. coqui is comparable to that of Gosner stage 44 in R. temporaria (Żuwała ).…”

Section: Discussionmentioning

confidence: 97%

Taste organ growth and development in the direct developing frog Eleutherodactylus coqui (Lissamphibia: Eleutherodactylidae)

2015

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Previous research on amphibian taste organs concerned amphibians with a biphasic life history, that is, with larval period and metamorphosis. Direct developing frog species, such as Eleutherodactylus coqui, undergo a cryptic metamorphosis before hatching, and many larval‐specific features are vestigial or have been lost entirely from their ontogeny. Taste buds are present in larval stages of biphasically developing anurans and are replaced by taste discs during metamorphosis. One goal of this study was to characterize the ontogeny of taste buds and/or discs in E. coqui. The other goal was to examine correlations between body size and taste organ density and size in different regions of oral epithelium. The research reveals the presence of only one type of taste organ, characteristic of metamorphs of biphasic amphibians, namely taste disc. In addition, taste disc density and the area of the taste disc sensory zone change dramatically during growth.

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“…; Viertel ; Żuwała , ; Toyoshima et al . ). At stage TS 15 and in hatchlings, the tongue fold of E. coqui is comparable to that of Gosner stage 44 in R. temporaria (Żuwała ).…”

Section: Discussionmentioning

confidence: 97%

Taste organ growth and development in the direct developing frog Eleutherodactylus coqui (Lissamphibia: Eleutherodactylidae)

2015

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“…In the most complex vertebrate taste organ, the frog taste disk, Toyoshima et al (1999) assigned the Merkel cell rather than nerves as the element more responsible for taste organ morphogenesis. Merkel cells are not present in mammalian lingual gustatory papillae.…”

Section: Taste Buds In Fish and Amphibiansmentioning

confidence: 99%

Building sensory receptors on the tongue

Oakley

Witt

2004

J Neurocytol

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Neurotrophins, neurotrophin receptors and sensory neurons are required for the development of lingual sense organs. For example, neurotrophin 3 sustains lingual somatosensory neurons. In the traditional view, sensory axons will terminate where neurotrophin expression is most pronounced. Yet, lingual somatosensory axons characteristically terminate in each filiform papilla and in each somatosensory prominence within a cluster of cells expressing the p75 neurotrophin receptor (p75NTR), rather than terminating among the adjacent cells that secrete neurotrophin 3. The p75NTR on special specialized clusters of epithelial cells may promote axonal arborization in vivo since its over-expression by fibroblasts enhances neurite outgrowth from overlying somatosensory neurons in vitro. Two classical observations have implicated gustatory neurons in the development and maintenance of mammalian taste buds--the early arrival times of embryonic innervation and the loss of taste buds after their denervation in adults. In the modern era more than a dozen experimental studies have used early denervation or neurotrophin gene mutations to evaluate mammalian gustatory organ development. Necessary for taste organ development, brain-derived neurotrophic factor sustains developing gustatory neurons. The cardinal conclusion is readily summarized: taste buds in the palate and tongue are induced by innervation. Taste buds are unstable: the death and birth of taste receptor cells relentlessly remodels synaptic connections. As receptor cells turn over, the sensory code for taste quality is probably stabilized by selective synapse formation between each type of gustatory axon and its matching taste receptor cell. We anticipate important new discoveries of molecular interactions among the epithelium, the underlying mesenchyme and gustatory innervation that build the gustatory papillae, their specialized epithelial cells, and the resulting taste buds.

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“…This suggests that neuronal-like cells are present in the differentiating tongue epithelium to persist in the adult taste organ. Such a suggestion is supported by the findings of Toyoshima et al (1999) showing the presence of non-innervated, serotonin-containing Merkel cells in the undifferentiated tongue epithelium of the bullfrog, Rana catesbeiana; later on in development, these cells become innervated and assume the position of basal cells in the mature taste disc. Interestingly, the presence of NIF proteins in subsets of epithelial cells is confirmed by findings in mammals: Fantini et al (1995) and Narisawa et al (1994) found immunoreactivity for neurofilaments and NF-H, respectively, in Merkel cells of the human skin and Pasche et al (1990) showed immunoreactivity for neurofilaments in Merkel cells of the mouse embryonic epidermis before nerve contact; moreover, Baudoin et al (1993) showed the presence of peripherin and NF-L in neuroendocrine carcinomas of the human skin.…”

mentioning

confidence: 99%

Neuronal intermediate filaments in the developing tongue of the frog Rana esculenta

Żuwała¹,

Merigo²,

Zancanaro³

2009

Eur J Histochem

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The expression of several neuronal intermediate filament (NIF) proteins was investigated in the tongue of metamorphosing tadpoles (stage 38-45 of Gosner) and in adult individuals of the frog, Rana esculenta by means of immunohistochemistry. Results showed that nerve fibres at early stages of tongue development expressed peripherin (a NIF protein usually found in differentiating neurones) as well as the light-and medium molecular weight NIF polypeptide subunits (NF-L and NF-M, respectively); in the adult frog, peripherin was still found in nerve fibres reaching the fungiform papilla together with NF-M, but NF-L immunoreactivity was absent therein. Clusters of epithelial cells expressing peripherin were found in the early developing tongue before differentiation of taste organs, and NF-L and NF-H immunoreactivities were present in basal (Merkel) cells of the adult frog taste disc. Results indicate that neurones innervating the adult frog's taste disc maintain a certain plasticity in their cytoskeleton and that neuronal-like cells are present in the undifferentiated and differentiated tongue epithelium possibly playing a role in the developing and mature taste organ.

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Merkel cells are responsible for the initiation of taste organ morphogenesis in the frog

Cited by 15 publications

References 57 publications

Taste organ growth and development in the direct developing frog Eleutherodactylus coqui (Lissamphibia: Eleutherodactylidae)

Taste organ growth and development in the direct developing frog Eleutherodactylus coqui (Lissamphibia: Eleutherodactylidae)

Building sensory receptors on the tongue

Neuronal intermediate filaments in the developing tongue of the frog Rana esculenta

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