Merkel cells in the stratified squamous nonkeratinized epithelium of the human oesophagus

Polakovičová, Simona; Mikušová, Renáta; Polák, Štefan

doi:10.2478/s11756-013-0195-1

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…The argument that keratin 20 + NEC in the esophagus is in fact esophageal MCC draws support from the presence of variable numbers of polygonal and dendritic cells in the basal squamous mucosa of the lower and mid‐esophagus (Fig. ) that are both keratin 20 + and immunoreactive for selected endocrine peptides . These cells also have ultrastructural similarities to Merkel cells, but tend not to associate with nerves .…”

Section: Primary Nonepithelial and Specialized Epithelial Tumors Of Ementioning

confidence: 96%

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Rare tumors of esophageal squamous mucosa

Tripathi

Swanson

2016

Annals of the New York Academy of Sciences

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In spite of increasing incidence of esophageal adenocarcinoma in the last few decades, esophageal squamous cell carcinoma (SCC) still remains the dominant subtype of esophageal cancer worldwide. Apart from conventional SCC, some rare unconventional tumors of esophageal squamous mucosa are also well known. This study provides an introduction to these and presents a brief review of the literature, including the diagnostic and prognostic importance of each variant.

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Section: Primary Nonepithelial and Specialized Epithelial Tumors Of Ementioning

confidence: 96%

“…6) that are both keratin 20 + and immunoreactive for selected endocrine peptides. 62,68 These cells also have ultrastructural similarities to Merkel cells, but tend not to associate with nerves. 62 They are thus likely the esophageal analogue of the singly dispersed epidermal Merkel cells found outside of the touch domes.…”

Section: Malignant Melanomamentioning

confidence: 99%

Rare tumors of esophageal squamous mucosa

Tripathi

Swanson

2016

Annals of the New York Academy of Sciences

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“… 19 Mostly, they are concentrated in the palms of the hands, predominantly in the finger pads, and in the soles and toes. 20 They are also present in the lips, hard palate and gingiva, 18 esophagus, 21 , 22 human eyelid. 23 The concentration of MCs in the external genitalia has not been studied, but Cold and Taylor 24 detected some MCs in the male prepuce and in the female clitoris.…”

Section: Introductionmentioning

confidence: 99%

Merkel-like cell distribution in the epithelium of the human vagina. An immunohistochemical and TEM study

et al. 2018

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Human Merkel cells (MCs) were first described by Friedrich S. Merkel in 1875 and named “Tastzellen” (touch cells). Merkel cells are primarily localized in the basal layer of the epidermis and concentrated in touch-sensitive areas. In our previous work, we reported on the distribution of MCs in the human esophagus, so therefore we chose other parts of the human body to study them. We selected the human vagina, because it has a similar epithelium as the esophagus and plays very important roles in reproduction and sexual pleasure. Due to the fact that there are very few research studies focusing on the innervation of this region, we decided to investigate the occurrence of MCs in the anterior wall of the vagina. The aim of our research was to identify MCs in the stratified squamous non-keratinized epithelium of the human vagina in 20 patients. For the identification of Merkel cells by light microscopy, we used antibodies against simple-epithelial cytokeratins (especially anti-cytokeratin 20). We also tried to identify them using transmission electron microscopy. Our investigation confirmed that 10 (50 %) of 20 patients had increased number of predominantly intraepithelial CK20 positive “Merkel-like” cells (MLCs) in the human vaginal epithelium. Subepithelial CK20 positive MLCs were observed in only one patient (5%). We tried to identify them also using transmission electron microscopy. Our investigation detected some unique cells that may be MCs. The purpose of vaginal innervation is still unclear. There are no data available concerning the distribution of MCs in the human vagina, so it would be interesting to study the role of MCs in the vaginal epithelium, in the context of innervation and epithelial biology.

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Morphological evaluation of Merkel cells and small lamellated sensory receptors in the equine foot

Bowker¹,

Lancaster

Isbell

2017

ajvr

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OBJECTIVE To examine the equine foot for the presence of sensory receptors including Merkel cells and small lamellated Pacinian-like corpuscles (SLPCs). SAMPLE Forefeet obtained from 7 horses following euthanasia for reasons other than foot disease. PROCEDURES Disarticulated feet were cut into either sagittal sections or cross sections and immersed in neutral-buffered 4% formalin. Following fixation, samples were obtained from the midline of the dorsal aspect of the hoof wall and from the frog (cuneus ungulae) between the apex and central sulcus. The formalin-fixed, paraffin-embedded hoof wall and frog sections were routinely processed for peroxidase immunohistochemistry and stained with H&E, Alcian blue, and Masson trichrome stains for histologic evaluation. RESULTS Sensory myelinated nerves and specific receptors were identified within the epidermal and dermal tissues of the equine foot including the hoof wall laminae, coronet, and frog. Merkel cells were identified with specific antisera to villin, cytokeratin 20, and protein gene product 9.5 in coronet epidermis and hoof wall. These cells were interspersed among basilar keratinocytes within the frog, coronary epidermis, and secondary epidermal laminae. The SLPCs were present within the superficial dermis associated with the central ridge of the frog (ie, frog stay). Numerous S100 protein and protein gene product 9.5 immunoreactive sensory nerves in close proximity to these receptors were present throughout the dermal tissues within both the frog and hoof wall. CONCLUSIONS AND CLINICAL RELEVANCE The presence of Merkel cells and SLPCs that are known to detect tactile and vibrational stimuli, respectively, further defined the diverse range of neural elements within the equine foot.

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Merkel cells in the stratified squamous nonkeratinized epithelium of the human oesophagus

Cited by 3 publications

References 11 publications

Rare tumors of esophageal squamous mucosa

Rare tumors of esophageal squamous mucosa

Merkel-like cell distribution in the epithelium of the human vagina. An immunohistochemical and TEM study

Morphological evaluation of Merkel cells and small lamellated sensory receptors in the equine foot

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