Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model

Kruszewska, D; Sahl, Hans‐Georg; Bierbaum, Gabriele; Pag, Ulrike; Hynes, Seán O.; Ljungh, Åsa

doi:10.1093/jac/dkh387

Cited by 200 publications

(122 citation statements)

References 33 publications

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“…Mersacidin has shown very promising activity against methicillin-resistant S. aureus. 32,33 Mersacidin interacts with a different part of lipid II compared with the current drug of last resort, vancomycin, suggesting it could be a complementary treatment strategy. 34 Figure 4 Nukacin ISK-1 mutants and structure-activity relationship conclusions.…”

Section: Mersacidin Is a Small Globular Lantibiotic That Is Produced Bymentioning

confidence: 99%

Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides

Ross

Vederas

2010

J Antibiot

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There has been great interest in the development of extremely potent antibacterial lantibiotic peptides for medicinal use and in food preservation. Of central importance to this endeavor is a strong understanding of which parts of the peptides are required for activity and which parts are expendable. Nisin, lacticin 481, nukacin ISK-1, mersacidin, lacticin 3147 and haloduracin represent many different types of lantibiotic peptides. In recent years, considerable advances toward understanding the structure-activity relationship of each of these lantibiotic systems have been achieved. This review will focus on the individual systems and the valuable information obtained from the many mutants produced.

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Section: Mersacidin Is a Small Globular Lantibiotic That Is Produced Bymentioning

confidence: 99%

Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides

Ross

Vederas

2010

J Antibiot

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“…Many non-lantibiotic bacteriocins, such as lactococcin appear to interact with membrane-associated receptor proteins, before their membrane perturbing activity. In contrast, a specific proteinaceous receptor for lantibiotic species on the outer surface of bacteria has not been found so far [27]. This study was designed to isolate the strains from hospital environment and to screen for the epidermin genes using traditional polymerase chain reaction (PCR).…”

Section: Rajan Et Almentioning

confidence: 99%

Molecular Evaluation of Antistaphylococcal Secondary Metabolites of Bacterial Isolates From Hospital Wastewater Environment

Rajan

Sudhakar

Bhaskar

et al. 2017

Asian J Pharm Clin Res

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Objective: Antibiotics revolutionized medicine in the 20 th century, and have together with vaccination led to the near eradication of diseases such as tuberculosis in the developed world. Their effectiveness and easy access led to overuse, especially in livestock raising, prompting bacteria to develop resistance. The lantibiotics form a particular group among the antimicrobial peptides and are characterized by unique structural features. They are produced by a group of bacteria against some gram-positive bacteria. The present study was designed to screen for the lantibiotic producing organisms from the hospital samples. Methods:The bacterial isolates were identified based on Bergey's manual of bacteriology and screened for the epidermin gene by polymerase chain reaction amplification. Results:Of the 21 isolates screened, only 10 of them showed positive amplification for the epigene. Based on the biochemical characteristics, the isolates obtained were identified and labeled. Conclusion:Further study on the purification of the compound need to be done. Some bacterial samples may not have the epidermin gene which does not show amplification, this confers that the epidermin gene is absent in certain organisms.

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“…A notable example is mersacidin, a tetracyclic peptide produced by Bacillus spp. which can suppress methicillin-resistant S. aureus and is comparable with vancomycin, but without the development of cross resistance (Chatterjee et al, 1992a and1992b;Kruszewska et al, 2004).…”

Section: Bacteriocins Of Gram Positive Bacteriamentioning

confidence: 99%

Microbial defense systems in foods and feeds

Fatima¹

2017

JBC

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Bacteriocins are proteinaceous substances having antigenic and developed by some microbial strains having the ability and effectiveness against pathogenic bacteria and spoilage, harmless to the consumer, and have no adverse effect on the organoleptic product quality. Bacteriocins are rendered inactive by the action of proteolytic enzymes present in the gastrointestinal tract, thy can resist high temperatures, are non-toxic and does not compromise the immune system in experimental animals. Bacteriocins as microbial defense systems has been widely researched and documented. However, though the diversity and abundance of bactrocins is very high, indicating their use as microbial weapons, research on ecological and evolutionary significance needs elaborate studies. More advanced studies are needed to unfold reasons for their success as toxins.

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Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model

Abstract: In the mouse rhinitis model, mersacidin was able to eradicate MRSA colonization. The site of action (epithelium versus blood) of mersacidin needs to be further explored.

Cited by 200 publications

References 33 publications

Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides

Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides

Molecular Evaluation of Antistaphylococcal Secondary Metabolites of Bacterial Isolates From Hospital Wastewater Environment

Microbial defense systems in foods and feeds

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