Mes2, a MADF‐containing transcription factor essential for <i>Drosophila</i> development

Zimmermann, Gregor; Furlong, Eileen E. M.; Suyama, Kaye; Scott, Matthew P.

doi:10.1002/dvdy.20970

Cited by 16 publications

(13 citation statements)

References 29 publications

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“…This is especially so for CG14207, Hsp22, Hsp23 and Hsp27, suggesting a non-essential role of those sHsps during fl y development under laboratory conditions (Hao et al 2007 ;Michaud and Tanguay 2003 ;Morrow et al 2004a ;Zimmermann et al 2006 ). While this may be due to a certain redundancy of sHsps function, even the deletion of locus 67B (seven sHsps) has no deleterious effect during development (Geiger-Thornsberry and Mackay 2004 ).…”

Section: Developmental Expression and Functionmentioning

confidence: 93%

Drosophila Small Heat Shock Proteins: An Update on Their Features and Functions

Morrow¹,

Tanguay²

2015

Heat Shock Proteins

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Small heat shock proteins (sHsps) are present in varying numbers in all organisms. In Drosophila melanogaster there are 12 sHsps, which have distinctive developmental expression patterns, intracellular localizations and substrate specifi cities. Even if most of Drosophila sHsps do not have a known mammalian ortholog, they share their involvement in multiple cellular processes such as cytoskeleton modulation, apoptosis and autophagy. New data on Drosophila sHsps have arisen from high-throughput genomic and proteomic studies as well as from deletion experiments. In addition to showing the complexity of this family, these experiments suggest the involvement of sHsps in new cellular processes such as the involvement of Hsp27 in piRNA biosynthesis. The goal of this review is to summarize the new fi ndings on each Drosophila sHsp and to highlight its similarity to other sHsps as well as its distinctive features.

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Section: Developmental Expression and Functionmentioning

confidence: 93%

Drosophila Small Heat Shock Proteins: An Update on Their Features and Functions

Morrow¹,

Tanguay²

2015

Heat Shock Proteins

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“…Progression through embryogenesis and hatching into first instar larvae were analyzed. In this screen (Zimmermann et al 2006), we identified the gene CG3983 as being essential for embryonic development. CG3983 is the Drosophila gene most closely related to the human gene NUCLEOSTEMIN (NS or GNL3), which encodes a nucleolar GTPase that regulates cell proliferation and cell fate (Tsai and McKay 2002).…”

Section: Identification Of the Drosophila Nucleostemin Familymentioning

confidence: 99%

A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size

Kaplan

Zimmermann²,

Suyama³

et al. 2008

Genes Dev.

Self Cite

106

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The overall size of an animal is determined by the number of cell divisions, the rate of destruction of cells, and the average size of cells (Conlon and Raff 1999;Edgar 2006). With some species, size is a relatively rigid outcome of the genetically controlled program of development. Other species, such as many fish and trees, can continue to grow through much of their lives. In both cases growth is influenced by continuing assessment of the energy state of the growing organism and the availability of nutrients, interpreted in the context of the organism's genetic program. The cell-intrinsic machinery that specifies whether or not a cell should divide and how large a cell should grow has been unveiled in elegant molecular detail (Conlon and Raff 1999;Edgar 2006). Much remains to be learned about the cell-extrinsic mechanisms that coordinate the growth behaviors of individual cells. Global cell-extrinsic controls are needed to ensure that a properly proportioned animal is produced, with a size suited to its environment and genetic program.Whole-animal growth control can be envisioned as having three components that operate in concert: (1) sensory and homeostatic inputs, (2) processing within the CNS, and (3) instructive outputs to the periphery. Sensory inputs to the CNS provide information regarding the energy status of the organism and the available nutrient status of the environment. The CNS assesses this information in light of the genetic program and instincts about future energy requirements; e.g., for growth, reproduction, migration, and hibernation. The CNS converts the processed information into output signals that alter feeding behavior and spread through the body to coordinate growth. The transmitted output signals instruct cells in peripheral tissues to grow, to cease growth, or to die, by influencing cell-intrinsic programs. Recent studies have shed light on the input and output signals involved in growth control (1 and 3). Much less is known about the central processing mechanisms (2).A great deal of elegant work has identified signaling mechanisms by which energy states are sensed and the information is relayed to the CNS (Morton et al. 2006;Melcher et al. 2007). In mammals, dietary free fatty acids can act on the anterior pituitary gland to inhibit growth hormone secretion (Dieguez and Casanueva 1995). In

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“…An open question in the field is the molecular function of MADF and MADF-BESS domain containing proteins. Members appear to modulate diverse processes ( Ratnaparkhi et al 2008 ; Song et al 2010 ; Cutler et al 1998 ; Duong et al 2008 ; Shukla et al 2014 ; Zimmermann et al 2006 ; Timmerman et al 2013 ; Casola et al 2007 ; Barbash et al 2000 ; Brideau et al 2006 ) with no apparent common theme. The MADF-BESS family members may either act as transcription activators/repressors or as histone modifiers, they may also associate with different subsets of co-factors for diverse functions.…”

Section: Discussionmentioning

confidence: 99%

Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline inDrosophila

Shukla

Dhiman

Nayak

et al. 2018

G3 Genes|Genomes|Genetics

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Proper specification of germline stem cells (GSCs) in Drosophila ovaries depends on niche derived non-autonomous signaling and cell autonomous components of transcriptional machinery. Stonewall (Stwl), a MADF-BESS family protein, is one of the cell intrinsic transcriptional regulators involved in the establishment and/or maintenance of GSC fate in Drosophila ovaries. Here we report identification and functional characterization of another member of the same protein family, CG3838/ Brickwall (Brwl) with analogous functions. Loss of function alleles of brwl exhibit age dependent progressive degeneration of the developing ovarioles and loss of GSCs. Supporting the conclusion that the structural deterioration of mutant egg chambers is a result of apoptotic cell death, activated caspase levels are considerably elevated in brwl- ovaries. Moreover, as in the case of stwl mutants, on several instances, loss of brwl activity results in fusion of egg chambers and misspecification of the oocyte. Importantly, brwl phenotypes can be partially rescued by germline specific over-expression of stwl arguing for overlapping yet distinct functional capabilities of the two proteins. Taken together with our phylogenetic analysis, these data suggest that brwl and stwl likely share a common MADF-BESS ancestor and they are expressed in overlapping spatiotemporal domains to ensure robust development of the female germline.

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Mes2, a MADF‐containing transcription factor essential for Drosophila development

Cited by 16 publications

References 29 publications

Drosophila Small Heat Shock Proteins: An Update on Their Features and Functions

Drosophila Small Heat Shock Proteins: An Update on Their Features and Functions

A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size

Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline inDrosophila

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