Mesenchymal chondrosarcoma of the vagus nerve

Abstract

Mesenchymal chondrosarcoma is a rare, aggressive, malignant neoplasm, which arises from extraskeletal sites in 30-40 per cent of cases. It is extremely rare in children. We present a novel case of childhood mesenchymal chondsarcoma arising from the vagus nerve in the neck, resulting in paralysis of the right vocal fold. The clinicopathologic features and management of this case are described along with a brief discussion on the aetiology of vocal fold paralysis in this age group. Current literature on extraskeletal presentation of mesenchymal chondrosarcoma is reviewed.

Extraskeletal Mesenchymal Chondrosarcoma in the Axillary Region: Reports of Two Cases

“…Plain radiography of EMC shows a soft-tissue mass with mineralized chondroid matrix due to arc-shaped or stippled calcification in over 50% of cases,10 and CT commonly depicts coarse calcification and predominantly peripheral enhancement 13. We observed plain radiographic abnormalities in case 2 of our study, but not in case 1.…”

“…Spindle cell areas are present in some cases but are rarely a prominent feature 10,14. However, there is no specific immunohistochemical marker for EMC 10,13…”

“…Furthermore, no reliable correlation has been established between the histological appearance and biological behavior of EMCs, but all should be considered high-grade tumors due to the presence of small round cells 13. To decide upon treatment protocols, Huvos et al15 divided patients into two histologic categories, namely, undifferentiated small cell types and hemangiopericytomatoid variants.…”

Congenital Intracranial Mesenchymal Chondrosarcoma: Case Report and Review of the Literature in Pediatric Patients

“…The case by Tuncer and colleagues [13] represents the 1st congenital MC described both in skeletal and extraskeletal sites (orbit), prior to the present case. Other unusual sites of extraskeletal MC described in the pediatric population (in patients less than 20 years of age) are thyroid [14], vagus nerve [15], lid [16], and sinonasal tract [17]. Surprisingly, in cases involving these unusual sites, the patients were all females.…”

Le chondrosarcome mésenchymateux des tissus mous, une tumeur rare. À propos d’un cas

“…Il peut se dé velopper dans 30 à 40 % des cas en extrasquelettique [3]. Nous rapportons un cas de chondrosarcome mé senchymateux extrasquelettique CMES de localisation cervicale en rappelant les diffé rentes caracté ristiques qui permettent de porter le diagnostic de cette tumeur à l'é volution particuliè rement lente.…”