Mesenchymal Stem Cell-Derived Exosome-Loaded microRNA-129-5p Inhibits TRAF3 Expression to Alleviate Apoptosis and Oxidative Stress in Heart Failure

Yan, Fang; Cui, Wei; Chen, Ziying

doi:10.1007/s12012-022-09743-9

Cited by 28 publications

(14 citation statements)

References 26 publications

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“…Several signaling pathways has been proved to regulate oxidative stress in HF, like Nrf2/HO-1/Ca2 + -SERCA2a axis ( 42 ), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway ( 43 ), and IL-6/STAT3 ( 44 ). Mesenchymal stem cell derived exosomes could inhibit oxidative stress, inflammation and cell apoptosis via inhibiting inflammatory related NF-κB pathway in HF ( 45 ). In chronic HF, the level of inflammation is associated with oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Global trends in research on oxidative stress related to heart failure from 2012 to 2021: a bibliometric analysis and suggestion to researchers

Pang¹,

Huang²,

Lu³

et al. 2023

Ann Transl Med

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Background Oxidative stress leads to an increase in reactive oxygen in the body. During heart failure (HF), when the body’s antioxidant defense system fails to remove excessive reactive oxygen species, myocardial cells will be damaged or even die. Over the past ten years, the number of research publications on oxidative stress related to HF has increased. Methods We searched publications published in 2012–2021 and the Web of Science Core Collection (WoSCC) recording information. Based on the VOSviewer and CiteSpace, we conducted a bibliometric analysis of the overall distribution of journals, keywords, authors, major countries, annual output, active institutions, and cocited literature. The Global Citation Score (GCS) was used to evaluate the impact and quality of highly cited papers. Results We retrieved 5,616 articles and reviews. Over the past ten years, the number of annual publications on oxidative stress related to HF has increased. USA has published the largest number of articles and obtained the highest number of citations (NC) and H-index. The University of California and PLoS One are the most productive affiliations and journals in terms of publications on oxidative stress related to HF. The GCS of articles written by Paulus WJ in 2013 was 1,632, which was the top ranking. The most frequent keywords are “oxidative stress”, “heart failure”, “inflammation”, “dysfunction” and “apoptosis”. The top three authors are Kang Yuming, Ren Jun and Okoshi Katashi. “Impact“, “induced myocardial infarction”, “cardiovascular outcome”, “empagliflozin”, “sglt2 inhibitor”, “protect”, and “Na + /H + exchanger” have become popular research topics. Conclusions Our research shows the research focus and development trends of oxidative stress related to HF in the past decade. Understanding the most important indicators of oxidative stress related to HF and the hot spots in the field of oxidative stress research related to HF can assist scholars, countries and policy-makers in the field in better understanding oxidative stress related to HF and can also lead to better decisions in oxidative stress treatment.

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Section: Discussionmentioning

confidence: 99%

Global trends in research on oxidative stress related to heart failure from 2012 to 2021: a bibliometric analysis and suggestion to researchers

Pang¹,

Huang²,

Lu³

et al. 2023

Ann Transl Med

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“…Moreover, as previously noted, MSC-EVs can temper neuroinflammation—a prevalent instigator of oxidative stress—potentially lessening oxidative stress intensity through inflammation reduction. For instance, they can exert their effects through various pathways, including the NF-kB signaling pathway ( Yan et al, 2022 ) and the Nrf2/Keap1 signaling pathway ( Tang et al, 2023 ). Additionally, they have the ability to modulate mitochondrial membrane potential and mitigate mitochondrial ROS production ( Xian et al, 2019 ).…”

Section: Role and Application Of Msc-evs In The Pathophysiological Pr...mentioning

confidence: 99%

Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia

Liu,

Cheng,

Zhang

et al. 2024

Front. Aging Neurosci.

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Vascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities, neuroinflammation, and oxidative stress, among others. In recent years, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have garnered significant attention as an emerging therapeutic strategy. Current research indicates that MSC-derived extracellular vesicles (MSC-EVs) play a pivotal role in both the diagnosis and treatment of VD. Thus, this article delves into the recent advancements of MSC-EVs in VD, discussing the mechanisms by which EVs influence the pathophysiological processes of VD. These mechanisms form the theoretical foundation for their neuroprotective effect in VD treatment. Additionally, the article highlights the potential applications of EVs in VD diagnosis. In conclusion, MSC-EVs present a promising innovative treatment strategy for VD. With rigorous research and ongoing innovation, this concept can transition into practical clinical treatment, providing more effective options for VD patients.

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“…In this study, miR-182 shuttling by sEVs targets Toll-like receptor 4 (TLR4), the inhibition of which leads to anti-inflammatory M2 macrophage conversion ( Vergadi et al, 2017 ), thus promoting macrophage polarization and alleviating inflammation. Similarly, another study showed that in an ischemia-induced mouse heart failure model, sEVs derived from BMMSCs improved cardiac function by inhibiting NF-κB signaling, a transcription factor for cytokine release, and miR-129-5p carried by sEVs was proven to target tumor necrosis factor receptor-associated factor 3 (TRAF3), which subsequently regulates NF-kB ( Yan et al, 2022 ). The anti-inflammatory effects of sEVs derived from BMMSCs were not only found in ischemic heart injury, doxorubicin-induced heart failure models and sepsis-induced heart failure models but also significantly reduced inflammatory factor release when BMMSC-derived sEVs are injected into hearts ( Wang et al, 2015 ; Sun et al, 2018 ; Pei et al, 2021 ).…”

Section: Anti-inflammatory Actions Of Bmmsc-sevs On Ihdmentioning

confidence: 99%

Bone marrow mesenchymal stromal cell-derived small extracellular vesicles: A novel therapeutic agent in ischemic heart diseases

Chang

2023

Front. Pharmacol.

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Myocardial injury is a major pathological factor that causes death in patients with heart diseases. In recent years, mesenchymal stromal cells (MSCs) have been generally used in treating many diseases in animal models and clinical trials. mesenchymal stromal cells have the ability to differentiate into osteocytes, adipocytes and chondrocytes. Thus, these cells are considered suitable for cardiac injury repair. However, mechanistic studies have shown that the secretomes of mesenchymal stromal cells, mainly small extracellular vesicles (sEVs), have better therapeutic effects than mesenchymal stromal cells themselves. In addition, small extracellular vesicles have easier quality control characteristics and better safety profiles. Therefore, mesenchymal stromal cell-small extracellular vesicles are emerging as novel therapeutic agents for damaged myocardial treatment. To date, many clinical trials and preclinical experimental results have demonstrated the beneficial effects of bone marrow-derived mesenchymal stromal cells (BMMSCs) and bone marrow-derived mesenchymal stromal cells-small extracellular vesicles on ischemic heart disease. However, the validation of therapeutic efficacy and the use of tissue engineering methods require an exacting scientific rigor and robustness. This review summarizes the current knowledge of bone marrow-derived mesenchymal stromal cells- or bone marrow-derived mesenchymal stromal cells-small extracellular vesicle-based therapy for cardiac injury and discusses critical scientific issues in the development of these therapeutic strategies.

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Mesenchymal Stem Cell-Derived Exosome-Loaded microRNA-129-5p Inhibits TRAF3 Expression to Alleviate Apoptosis and Oxidative Stress in Heart Failure

Cited by 28 publications

References 26 publications

Global trends in research on oxidative stress related to heart failure from 2012 to 2021: a bibliometric analysis and suggestion to researchers

Global trends in research on oxidative stress related to heart failure from 2012 to 2021: a bibliometric analysis and suggestion to researchers

Emerging role of mesenchymal stem cells-derived extracellular vesicles in vascular dementia

Bone marrow mesenchymal stromal cell-derived small extracellular vesicles: A novel therapeutic agent in ischemic heart diseases

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