Mesenchymal stem cell-derived exosome microRNA as therapy for cardiac ischemic injury

Nasser, M; Masood, Muqaddas; Adlat, Salah; Deng, Gang; Zhu, Shuoji; Li, Ge; Li, Nanbo; Chen, Jimei; Zhu, Ping

doi:10.1016/j.biopha.2021.112118

Cited by 45 publications

(26 citation statements)

References 90 publications

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“…In the mouse model, compared with the use of liposomes, exosomes are able to enter cells more effectively with less immune clearance in vivo ( Ferguson and Nguyen, 2016 ; Barile and Vassalli, 2017 ; Liao et al, 2019 ). Exosomes play an important role in cardiovascular function regulation and cardiovascular and cancer therapy ( Li et al, 2021a ; Lim, 2021 ; Nasser et al, 2021 ; Robson, 2021 ). With the development of technology, artificial exosomes have been used to deliver various nanomedicines ( Li et al, 2021b ).…”

Section: Exosomementioning

confidence: 99%

Microglia Polarization: A Novel Target of Exosome for Stroke Treatment

Wan

Zhao

Gao

et al. 2022

Front. Cell Dev. Biol.

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The vast majority of cells in the human body are capable of secreting exosomes. Exosomes have become an important vehicle for signaling between cells. Exosomes secreted by different cells have some of the structural and functional properties of that cell and thus have different regulatory functions. A large number of recent experimental studies have shown that exosomes from different sources have different regulatory effects on stroke, and the mechanisms still need to be elucidated. Microglia are core members of central intrinsic immune regulatory cells, which play an important regulatory role in the pathogenesis and progression of stroke. M1 microglia cause neuroinflammation and induce neurotoxic effects, while M2 microglia inhibit neuroinflammation and promote neurogenesis, thus exerting a series of neuroprotective effects. It was found that there is a close link between exosomes and microglia polarization, and that exosome inclusions such as microRNAs play a regulatory role in the M1/M2 polarization of microglia. This research reviews the role of exosomes in the regulation of microglia polarization and reveals their potential value in stroke treatment.

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Section: Exosomementioning

confidence: 99%

Microglia Polarization: A Novel Target of Exosome for Stroke Treatment

Wan

Zhao

Gao

et al. 2022

Front. Cell Dev. Biol.

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“…MSC release vesicles of various sizes loaded with miRNAs primarily for cell-to-cell communication. Research has shown that MSC-derived exosomes could accumulate in the ischemic myocardial tissue and regulate cell proliferation, apoptosis, inflammation, and angiogenesis [ 51 , 52 ]. Exosomes can be used as drug delivery systems by being loaded with the required miRNAs to the target organ of interest, such as the heart.…”

Section: Msc-derived Exosomes As Therapy In Different Cvdsmentioning

confidence: 99%

New Approaches for Enhancement of the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Diseases

Ahmed

Al-Massri

2022

Tissue Eng Regen Med

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Cardiovascular diseases (CVDs) remain a major health concern worldwide, where mesenchymal stem cells (MSCs) therapy gives great promise in their management through their regenerative and paracrine actions. In recent years, many studies have shifted from the use of transplanted stem cells to their secreted exosomes for the management of various CVDs and cardiovascular-related diseases including atherosclerosis, stroke, myocardial infarction, heart failure, peripheral arterial diseases, and pulmonary hypertension. In different models, MSC-derived exosomes have shown beneficial outcomes similar to cell therapy concerning regenerative and neovascular actions in addition to their anti-apoptotic, anti-remodeling, and anti-inflammatory actions. Compared with their parent cells, exosomes have also demonstrated several advantages, including lower immunogenicity and no risk of tumor formation. However, the maintenance of stability and efficacy of exosomes after in vivo transplantation is still a major concern in their clinical application. Recently, new approaches have been developed to enhance their efficacy and stability including their preconditioning before transplantation, use of genetically modified MSC-derived exosomes, or their utilization as a targeted drug delivery system. Herein, we summarized the use of MSC-derived exosomes as therapies in different CVDs in addition to recent advances for the enhancement of their efficacy in these conditions. Graphical abstract

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“…Nowadays, exosomal miRNAs are regarded as novel biomarkers for cervical cancer prediction and diagnosis [ 131 , 132 ]. Moreover, BMSCs-derived exosomal miR-150–5p can inhibit the apoptosis of cardiomyocytes and improve the cardiac function via targeting Bax [ 133 , 134 ]. In addition, exosomes derived from BMSCs contained higher miR-29 and miR-24 and lower miR-21, miR-34, and miR-378.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…In addition, exosomes derived from BMSCs contained higher miR-29 and miR-24 and lower miR-21, miR-34, and miR-378. These exosomal miRNAs can improve cardiac function by attenuating fibrosis and inflammation in the rat model of myocardial infarction [ 133 , 135 ].Except for MSCs, neurons, microglia and oligodendrocytes, emerging studies also indicate that astrocytes-derived exosomal miR-26a may impact neuronal function and morphology [ 136 ] and infiltrated macrophages after SCI could aggravate BSCB integrity breakdown by delivering exosomal miR-155 through activating the NF-κB pathway [ 137 ]. Nevertheless, it has not been well studied whether exosomes can accurately transfer miRNAs from their parent cells to their target cells, and the functions of regulating post-transcriptional translation and contribution of SCI and TBI are not transparent.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury

Pan

Liu

Zhu

et al. 2021

Journal of Orthopaedic Translation

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Spinal cord injury (SCI) is a disastrous situation that affects many patients worldwide. A profound understanding of the pathology and etiology of SCI is of great importance in inspiring new therapeutic concepts and treatment. In recent years, exosomes, which are complex lipid membrane structures secreted nearly by all kinds of plants and animal cells, can transport their valuable cargoes (e.g., proteins, lipids, RNAs) to the targeted cells and exert their communication and regulation functions, which open up a new field of treatment of SCI. Notably, the exosome's advantage is transporting the carried material to the target cells across the blood–brain barrier and exerting regulatory functions. Among the cargoes of exosomes, microRNAs, through the modulation of their mRNA targets, emerges with great potentiality in the pathological process, diagnosis and treatment of SCI. In this review, we discuss the role of miRNAs transported by different cell-derived exosomes in SCI that are poised to enhance SCI-specific therapeutic capabilities of exosomes.

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Mesenchymal stem cell-derived exosome microRNA as therapy for cardiac ischemic injury

Cited by 45 publications

References 90 publications

Microglia Polarization: A Novel Target of Exosome for Stroke Treatment

Microglia Polarization: A Novel Target of Exosome for Stroke Treatment

New Approaches for Enhancement of the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Diseases

Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury

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