2016
DOI: 10.3389/fbioe.2016.00038
|View full text |Cite
|
Sign up to set email alerts
|

Mesenchymal Stem Cell Fate: Applying Biomaterials for Control of Stem Cell Behavior

Abstract: The materials pipeline for biomaterials and tissue engineering applications is under continuous development. Specifically, there is great interest in the use of designed materials in the stem cell arena as materials can be used to manipulate the cells providing control of behavior. This is important as the ability to “engineer” complexity and subsequent in vitro growth of tissues and organs is a key objective for tissue engineers. This review will describe the nature of the materials strategies, both static an… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

0
52
0

Year Published

2016
2016
2023
2023

Publication Types

Select...
6
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 65 publications
(52 citation statements)
references
References 130 publications
(163 reference statements)
0
52
0
Order By: Relevance
“…Recognizing what cues and factors take priority in how cells react and then being able to tune these accordingly would provide more cell reprogramming control and specificity. The current challenge is to develop niche-mimicking biomaterials as a system where stem cells will be activated either manually or autonomously to a specific cell phenotype on demand [111]. Therefore, using all the known microenvironmental factors to engineer better cell niches will prove to be advantageous.…”
Section: Discussionmentioning
confidence: 99%
“…Recognizing what cues and factors take priority in how cells react and then being able to tune these accordingly would provide more cell reprogramming control and specificity. The current challenge is to develop niche-mimicking biomaterials as a system where stem cells will be activated either manually or autonomously to a specific cell phenotype on demand [111]. Therefore, using all the known microenvironmental factors to engineer better cell niches will prove to be advantageous.…”
Section: Discussionmentioning
confidence: 99%
“…Spreading of the cells on the underlying substrate alters the organization of cytoskeletal elements and creates intracellular forces, which ultimately changes the cellular morphology . Changes in the size and shape of the cells were shown to generate high degrees of cytoskeletal tension, alter the cytoskeletal and nuclear morphologies, and modulate the gene expression through mechanotransduction, which in turn influences the cell behavior including survival, proliferation, and even lineage commitment . Osteoblasts, for instance, differentiate into mechanosensitive osteocytes upon being entrapped within the small pockets called lacunae of the bone tissues, and their cuboid shape transforms into a highly branched, stellate morphology .…”
mentioning
confidence: 99%
“…25,26 Furthermore, one study also shows that stimulation of a immunomodulating pathway can lead to a morphological response in BM-MSCs. 57,58 Thus, culturing hBM-MSCs on biomaterials with specific microstructure 59,60 or stimulation of certain pathways 57 could be used to obtained clinically relevant cell population with high OB differentiation potential or immunomodulatory properties suitable for clinical transplantation.…”
Section: Discussionmentioning
confidence: 99%