Mesenchymal Stem Cell‐Mediated Delivery of the Sodium Iodide Symporter Supports Radionuclide Imaging and Treatment of Breast Cancer

Dwyer, Róisín M.; Ryan, J J; Havelin, Ronan J.; Morris, John C.; Miller, Brian W.; Liu, Zhonglin; Flavin, Richard; O’Flatharta, Cathal; Foley, Mark; Barrett, Harrison H.; Murphy, Mary; Barry, Frank; O’Brien, Timothy; Kerin, Michael J.

doi:10.1002/stem.665

Cited by 79 publications

(76 citation statements)

References 48 publications

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“…Nine out of 32 studies, with heterogeneous study design, met the predefined inclusion criteria and all were reviewed Of these, six studies were phase I (Dwyer et al, 2007;Woodward et al, 2007;Vlashi et al, 2009;Grisendi et al, 2010;Dwyer et al, 2011;Milane et al, 2011)and three were phase II clinical trials (Table 1) (Ueno et al, 2009;Resetkova et al, 2010;Viens et al, 2010). There was no published paper regarding phase III clinical trial on stem cell targeted therapy of breast cancer within the period of this study.…”

Section: Search Resultsmentioning

confidence: 99%

“…Moreover, in a recent study Dwyer et al (2011) showed that MSC-mediated expression of the sodium iodide symporter (NIS) is potentially is appropriate for imaging, tracking and therapy of breast cancer. By injection of MSC-NIS, human NIS (hNIS) gene expression in various tumor sites occurred and a significant reduction of tumor growth was observed.…”

Section: Discussionmentioning

confidence: 99%

“…MSC have been also used as cellular vehicles for tumor targeted delivery of therapeutic agents (Dwyer et al, 2011). Adipose Derived Mesenchymal stromal/stem cells (AD-MSC) armed with TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) has been offered as proficient tools for cell-based gene therapy for incurable cancers (Grisendi et al, 2010).…”

Section: The Use Of Stem Cells In Combination With Therapeutic Agentsmentioning

confidence: 99%

See 2 more Smart Citations

Application of Stem Cells in Targeted Therapy of Breast Cancer: A Systematic Review

Madjd

Gheytanchi²,

Erfani³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Search Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: The Use Of Stem Cells In Combination With Therapeutic Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Application of Stem Cells in Targeted Therapy of Breast Cancer: A Systematic Review

Madjd

Gheytanchi²,

Erfani³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…We and others have shown that MSCs are actively recruited to growing tumour stroma (Conrad et al 2007, Zischek et al 2009, Knoop et al 2011, Knoop et al 2013) mediated by high local concentrations of inflammatory chemokines and growth factors (Ponte et al 2007, Spaeth et al 2008, Kholodenko et al 2013. This tumour tropism constitutes the basis for the 'Trojan horse' approach, in which MSCs are used as shuttle vectors to deliver therapeutic agents into growing tumours , Dwyer et al 2011, Dembinski et al 2013, Zhu et al 2014, Zhang et al 2015, as we have successfully demonstrated in our previous work using the sodium iodide symporter (NIS) (Knoop et al 2011, Knoop et al 2013 and herpes simplex virus type 1 thymidine kinase (HSV-TK) (Zischek et al 2009 as therapy genes in various tumour models.…”

Section: Introductionmentioning

confidence: 99%

Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3

Schmohl¹,

Müller²,

Wechselberger³

et al. 2015

Endocrine-Related Cancer

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To improve our understanding of non-genomic, integrin avb3-mediated thyroid hormone action in tumour stroma formation, we examined the effects of triiodo-L-thyronine (T 3 ), L-thyroxine (T 4 ) and integrin-specific inhibitor tetrac on differentiation, migration and invasion of mesenchymal stem cells (MSCs) that are an integral part of the tumour's fibrovascular network. Primary human bone marrow-derived MSCs were treated with T 3 or T 4 in the presence of hepatocellular carcinoma (HCC) cell-conditioned medium (CM), which resulted in stimulation of the expression of genes associated with cancer-associated fibroblast-like differentiation as determined by qPCR and ELISA. In addition, T 3 and T 4 increased migration of MSCs towards HCC cell-CM and invasion into the centre of three-dimensional HCC cell spheroids. All these effects were tetrac-dependent and therefore integrin avb3-mediated. In a subcutaneous HCC xenograft model, MSCs showed significantly increased recruitment and invasion into tumours of hyperthyroid mice compared to euthyroid and, in particular, hypothyroid mice, while treatment with tetrac almost completely eliminated MSC recruitment. These studies significantly improve our understanding of the anti-tumour activity of tetrac, as well as the mechanisms that regulate MSC differentiation and recruitment in the context of tumour stroma formation, as an important prerequisite for the utilisation of MSCs as gene delivery vehicles.

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“…In line with this, types of stem cells, and especially mesenchymal stem cells (MSCs), that have been evaluated in several tumor models including breast, prostate, and ovarian cancer are used (11,15,23). However, the data are not adequate and some are contradictory to each other.…”

mentioning

confidence: 99%

Effects of the two types of human cells on outgrowth of human glioma in rats

Abdi

Eskandary²,

Nematollahi-Mahani³

2016

Turkish Neurosurgery

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In early cell-therapy studies (in the treatment of cancer), Aboody et al. (2) showed significant migration of neural stem cells (NSCs) towards the tumor area. In line with this, types of stem cells, and especially mesenchymal stem cells (MSCs), that have been evaluated in several tumor models including breast, prostate, and ovarian cancer are used (11,15,23). However, the data are not adequate and some are contradictory to each other.Olfactory ensheathing cell (OEC) is a neural stem cell type of the glial family like astrocytes and Schwann cells (35). In the recent decade, several reports have provided evidence that █ INTRODuCTION G lioblastoma (GBM) is one of the primary malignant brain tumors that occur most frequently. Nearly, all patients with GBM die within 12-15 months of the initial diagnosis (3,7,25). Therapies are still limited due to the ability of the blood brain barrier (BBB) to prevent the crossing of a broad range of anti-cancer agents (10,19). Therefore, the cure of GBM is a major concern. Accordingly, there is a lot of interest in devising novel approaches, such as stem cell therapy, to treat patients with GBM (10,12).AIm: Glioblastoma multiforme (GBM) is one of the malignant brain tumors that occur most frequently. Despite advances in therapy techniques, the cure of GBM is a major concern. Accordingly, there is a lot of interest in devising novel approaches, such as stem cell therapy, to treat patients with GBM. The aim of this study was to investigate the effects of human bone marrow stem (BMS) cells as well as human olfactory ensheathing cells (OECs) on the outgrowth of U87 glioma in rats. mATERIAl and mEThODS:OECs and BMS cells were obtained from volunteers. After verification of the stem cell type by flow cytometry and immunocytochemistry (ICC), cells were labeled and injected into human glioma-bearing rats. Magnetic resonance imaging (MRI), Hematoxylin and Eosin (H&E), and Immunohistochemistry (IHC) were utilized to assess the properties of the groups. RESulTS:We found extensive migration and homing of the OECs and BMS cells towards the tumor area. H&E and IHC staining indicated that the grafted OECs survived and prevented the development of glioma. BMS cells supported proliferation and new vessel formation, and metastasis in glioma tissue. CONCluSION:OECs and BMS cells can pass the blood brain barrier and reach the glioma mass. Therefore, this approach can be a potentially powerful method for the delivery of therapeutic agents to malignant brain tumors. In addition, these cells may be genetically modified in order to specifically express tumor-suppressive factors.

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Mesenchymal Stem Cell‐Mediated Delivery of the Sodium Iodide Symporter Supports Radionuclide Imaging and Treatment of Breast Cancer

Cited by 79 publications

References 48 publications

Application of Stem Cells in Targeted Therapy of Breast Cancer: A Systematic Review

Application of Stem Cells in Targeted Therapy of Breast Cancer: A Systematic Review

Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3

Effects of the two types of human cells on outgrowth of human glioma in rats

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