Mesenchymal stem cell-seeded porous tantalum-based biomaterial: A promising choice for promoting bone regeneration

Zhou, Zimo; Li, Da

doi:10.1016/j.colsurfb.2022.112491

Cited by 19 publications

(12 citation statements)

References 74 publications

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“…Porous metals with a combination of suitable mechanical properties, biomimic porous structure, and bone ingrowth ability are promising candidates for clinical applications. − Since tantalum (Ta) has demonstrated excellent biocompatibility, researchers have devoted plenty of efforts to fabricating porous Ta for osseointegration and osteogenesis. − Porous Ta with regular pores has been fabricated using laser-engineered net shaping, infiltration onto carbon scaffolding, and 3D printing and exhibits superb capability of bone repair both in vitro and in vivo . − These reported porous Ta scaffolds showed matchable moduli in the range of 1.5–20 GPa, which are comparable to that of human bone . Recent studies also show the surface functionalization related to porous Ta, such as coating porous Ta onto the titanium alloy, immobilizing magnesium ions on porous Ta, and loading bone morphogenetic protein to porous Ta, for improved performance on bone defect repair. − The heterogeneous structure of bone provides not only load-bearing function (from the dense osteon) but also proper tissue space and interconnected capillaries (hierarchical porosity) for bone remodeling, which should be a critical consideration for next-generation implant design .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair

Liang

Zhong

Jiang

et al. 2023

ACS Biomater. Sci. Eng.

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Porous tantalum (Ta) is a potential bone substitute due to its excellent biocompatibility and desirable mechanical properties. In this work, a series of porous Ta materials with interconnected micropores and varying pore sizes from 23 to 210 μm were fabricated using spark plasma sintering. The porous structure was formed by thermal decomposition of ammonium bicarbonate powder premixed in the Ta powder. The pore size and porosity were controlled by the categorized particle size of ammonium bicarbonate. The porous Ta has elastic moduli in the range of 2.1−3.2 GPa and compressive yield strength in the range of 23−34 MPa, which are close to those of human bone. In vitro, as-fabricated porous Ta demonstrates excellent biocompatibility by supporting adhesion and proliferation of preosteoblasts. In vivo studies also validate its bone repair capability after implantation in a rat femur defect model. The study demonstrates a facile strategy to fabricate porous Ta with controllable pore size for bone repair.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair

Liang

Zhong

Jiang

et al. 2023

ACS Biomater. Sci. Eng.

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“…The layer of Ta 2 O 5 is formed when pure Ta is oxidized, making it highly corrosionresistant. [88,89] Ta metal can provide effective support for bone tissue growth owing to its good corrosion resistance and durability after implantation and is a permanent biomedical implant material with good biocompatibility. [88] Owing to its superior physicochemical properties and bioaffinity, Ta has been continuously developed for biomedical applications.…”

Section: Ta Metalmentioning

confidence: 99%

Metallic Materials for Bone Repair

Fan,

Chen,

Yang

et al. 2023

Adv Healthcare Materials

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Repair of large bone defects caused by trauma or disease poses significant clinical challenges. Extensive research has focused on metallic materials for bone repair because of their favorable mechanical properties, biocompatibility, and manufacturing processes. Traditional metallic materials, such as stainless steel and titanium alloys, are widely used in clinics. Biodegradable metallic materials, such as iron, magnesium, and zinc alloys, are promising candidates for bone repair because of their ability to degrade over time. Emerging metallic materials, such as porous tantalum and bismuth alloys, have gained attention as bone implants owing to their bone affinity and multifunctionality. However, these metallic materials encounter many practical difficulties that require urgent improvement. In this article, we systematically reviewed and analyzed the metallic materials used for bone repair, providing a comprehensive overview of their morphology, mechanical properties, biocompatibility, and in vivo implantation. Furthermore, we summarized the strategies and efforts made to address the short‐comings of metallic materials. Finally, we identified and discussed perspectives for the development of metallic materials to guide future research and advancements in clinical practice.This article is protected by copyright. All rights reserved

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“…The role of trabecular tantalum in regulating the behavior of BMSCs to enhance bone regeneration was recently deepened in the work by Zhou and Liu [ 94 ]. This was an exhaustive review elucidating the beneficial features of porous tantalum from a general point of view, even describing its superior ability to favor osteogenic differentiation through the regulation of specific genes and the activation of signaling pathways.…”

Section: Bone Tissue Regeneration Induced By Tantalummentioning

confidence: 99%

Tantalum as Trabecular Metal for Endosseous Implantable Applications

Carraro

Bagno

2023

Biomimetics

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During the last 20 years, tantalum has known ever wider applications for the production of endosseous implantable devices in the orthopedic and dental fields. Its excellent performances are due to its capacity to stimulate new bone formation, thus improving implant integration and stable fixation. Tantalum’s mechanical features can be mainly adjusted by controlling its porosity thanks to a number of versatile fabrication techniques, which allow obtaining an elastic modulus similar to that of bone tissue, thus limiting the stress-shielding effect. The present paper aims at reviewing the characteristics of tantalum as a solid and porous (trabecular) metal, with specific regard to biocompatibility and bioactivity. Principal fabrication methods and major applications are described. Moreover, the osteogenic features of porous tantalum are presented to testify its regenerative potential. It can be concluded that tantalum, especially as a porous metal, clearly possesses many advantageous characteristics for endosseous applications but it presently lacks the consolidated clinical experience of other metals such as titanium.

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Mesenchymal stem cell-seeded porous tantalum-based biomaterial: A promising choice for promoting bone regeneration

Cited by 19 publications

References 74 publications

Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair

Fabrication of Porous Tantalum with Low Elastic Modulus and Tunable Pore Size for Bone Repair

Metallic Materials for Bone Repair

Tantalum as Trabecular Metal for Endosseous Implantable Applications

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