Mesenchymal stem cells encapsulated in a reactive oxygen species-scavenging and O2-generating injectable hydrogel for myocardial infarction treatment

Ding, Hao; Ding, Jie; Liu, Qingnian; Lin, Junxin; He, Mengying; Wu, Xinyu; Chen, Xiaoying; Xiao, Changchen; Ren, Tanchen; Zhu, Yang; Gao, Changyou; Hu, Xinyang; Wang, Jianan

doi:10.1016/j.cej.2021.133511

Cited by 27 publications

(22 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PTK hydrogels delivered strong anti-ROS protection for an enhanced encapsulated mesenchymal stem cell retention and viability 107 . Similarly, a class of polymers containing thioketal linkages has been reported for excellent myocardial infarction therapeutic effect in vivo 108 . Thioketal diethyl amine and polyethylene glycol diacrylate were used to synthesise the ROS-scavenging polymers, which were then copolymerized with methacrylate hyaluronic acid to form a UV-response hydrogel 108 .…”

Section: Recent Development Of Injectable Antioxidative Hydrogelsmentioning

confidence: 98%

“…Thioketal diethyl amine and polyethylene glycol diacrylate were used to synthesise the ROS-scavenging polymers, which were then copolymerized with methacrylate hyaluronic acid to form a UV-response hydrogel 108 . In addition to the ROS-scavenging ability, a commercially available and biocompatible catalase (CAT) that can turn H2O2 to O2, was also entrapped during the hydrogel formation and presented excellent treatment effects combined with the ROS-scavenging hydrogels 108 . Sugar alcohols present free radical scavenging abilities.…”

Section: Recent Development Of Injectable Antioxidative Hydrogelsmentioning

confidence: 99%

See 1 more Smart Citation

Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword

Newland

et al. 2021

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Section: Recent Development Of Injectable Antioxidative Hydrogelsmentioning

confidence: 98%

Section: Recent Development Of Injectable Antioxidative Hydrogelsmentioning

confidence: 99%

Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword

Newland

et al. 2021

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…Additionally, injectable hydrogels can incorporate bioactive cargo for minimally invasive injection. A novel injectable hydrogel (RCGel) was used to encapsulate transplanted MSCs to boost the cell engraftment under oxidative stress conditions and protect against ROS injury by inhibiting the JNK/p38 apoptosis signaling pathway . Also, an exosome-anchoring injectable hydrogel was constructed to prolong the retention rate of exosomes and avoid arrhythmia in the treatment of MI …”

Section: Hydrogels With Heart-specific Mimicry and Functionalitymentioning

confidence: 99%

Insight into Heart-Tailored Architectures of Hydrogel to Restore Cardiac Functions after Myocardial Infarction

et al. 2022

View full text Add to dashboard Cite

With permanent heart muscle injury or death, myocardial infarction (MI) is complicated by inflammatory, proliferation and remodeling phases from both the early ischemic period and subsequent infarct expansion. Though in situ re-establishment of blood flow to the infarct zone and delays of the ventricular remodeling process are current treatment options of MI, they fail to address massive loss of viable cardiomyocytes while transplanting stem cells to regenerate heart is hindered by their poor retention in the infarct bed. Equipped with heart-specific mimicry and extracellular matrix (ECM)-like functionality on the network structure, hydrogels leveraging tissue-matching biomechanics and biocompatibility can mechanically constrain the infarct and act as localized transport of bioactive ingredients to refresh the dysfunctional heart under the constant cyclic stress. Given diverse characteristics of hydrogel including conductivity, anisotropy, adhesiveness, biodegradability, self-healing and mechanical properties driving local cardiac repair, we aim to investigate and conclude the dynamic balance between ordered architectures of hydrogels and the post-MI pathological milieu. Additionally, our review summarizes advantages of heart-tailored architectures of hydrogels in cardiac repair following MI. Finally, we propose challenges and prospects in clinical translation of hydrogels to draw theoretical guidance on cardiac repair and regeneration after MI.

show abstract

“…As shown in Figure 4 a, MSCs were encapsulated in a hydrogel consisting of ROS-scavenging HBPAK (hyperbranched polymers), O 2 -generating CAT (catalase), and HA-MA (methacrylate hyaluronic acid). MSCs can maintain good viability, inhibit the activation of ROS-induced JNK/p38 apoptosis signaling pathway, and greatly improve the survival rate under oxidative stress conditions [ 106 ]. More importantly, the apoptosis level of mesenchymal stem cells also decreased in a hypoxia environment.…”

Section: Hydrogel As a Carrier For Transplanted Cellsmentioning

confidence: 99%

Research Advances of Injectable Functional Hydrogel Materials in the Treatment of Myocardial Infarction

Yang

Guo

et al. 2022

Gels

View full text Add to dashboard Cite

Myocardial infarction (MI) has become one of the serious diseases threatening human life and health. However, traditional treatment methods for MI have some limitations, such as irreversible myocardial necrosis and cardiac dysfunction. Fortunately, recent endeavors have shown that hydrogel materials can effectively prevent negative remodeling of the heart and improve the heart function and long-term prognosis of patients with MI due to their good biocompatibility, mechanical properties, and electrical conductivity. Therefore, this review aims to summarize the research progress of injectable hydrogel in the treatment of MI in recent years and to introduce the rational design of injectable hydrogels in myocardial repair. Finally, the potential challenges and perspectives of injectable hydrogel in this field will be discussed, in order to provide theoretical guidance for the development of new and effective treatment strategies for MI.

show abstract

Mesenchymal stem cells encapsulated in a reactive oxygen species-scavenging and O2-generating injectable hydrogel for myocardial infarction treatment

Cited by 27 publications

References 38 publications

Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword

Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword

Insight into Heart-Tailored Architectures of Hydrogel to Restore Cardiac Functions after Myocardial Infarction

Research Advances of Injectable Functional Hydrogel Materials in the Treatment of Myocardial Infarction

Contact Info

Product

Resources

About