Mesenchymal stem cells, exosomes and exosome-mimics as smart drug carriers for targeted cancer therapy

Li, Hongmei; Deng, Shichen; Han, Lu; Ren, Yan-Fang; Gu, Jian; He, Lili; Liu, Tianqing; Yuan, Zhixiang

doi:10.1016/j.colsurfb.2021.112163

Cited by 32 publications

(17 citation statements)

References 179 publications

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“…Therefore, exosomes released from cells like RBCs, platelets, MSCs, and immature DCs, can shield the loads against immune clearance from the body owing to their bilayer membranes with the inherited surface proteins like CD47, CD55, CD59, etc. , consequently prolonging their existence period and improving their biological behaviors [ [106] , [107] , [108] ]. Exosomes from RBCs were selected to act as the proper carrier for efficient RNA delivery in an RNA DDS.…”

Section: Immune-regulating Camouflaged Nanoplatformsmentioning

confidence: 99%

Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy

Chen

Zhao²,

Zhang³

et al. 2023

Bioactive Materials

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Section: Immune-regulating Camouflaged Nanoplatformsmentioning

confidence: 99%

Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy

Chen

Zhao²,

Zhang³

et al. 2023

Bioactive Materials

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“…(5) Exosomal delivery [79]. Has a strong biological barrier permeability to selectively penetrate tissue injury due to its natural ability to target donor cells based on its ability to deliver drugs and has nanomolecules of cell surface material [80]. This method of delivering miRNA to the site of spinal cord injury has great potential for application.…”

Section: Challenges For Mirna-based Clinical Therapies 421 Mode Of Ad...mentioning

confidence: 99%

Research Progress of MicroRNAs in Spinal Cord Injury

Deng¹,

Chen²

2023

J. Integr. Neurosci.

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Spinal cord injury is a serious and devastating condition. Recently, research into microRNAs (miRNAs) has become increasingly exhaustive and it has been determined that they are closely related to the pathophysiological processes of spinal cord injury. They participate in the regulation of the inflammatory response of spinal cord injury, the death of neuronal cells, and the repair of neural functions, which are related to the recovery of spinal cord injury. This review focuses on the relationship between miRNA and spinal cord injury, lists miRNA-324-5p, miRNA-221 and miRNA-124, which are helpful for the repair of spinal cord injury, and finally summarizes the current research progress of miRNA-based therapies, so as to provide a foundational reference for clinical and scientific researchers.

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“…In recent years, attention has been paid to the use of hybrid cell membrane camouflage and synthesis of nanoparticles, which is the direction of our group’s research. 200 The camouflage of synthetic nanoparticles (NPs) with natural cell membranes not only retains the physical and chemical characteristics of synthetic carriers, but also inherits the inherent functions of cell membranes, providing significant features such as immune evasion, long-term circulation, and homotypic targeting. Compared with single-cell membranes, hybrid cell membranes can produce synthetic nanoparticles with a variety of biological functions from the original cell.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics

Wang¹,

Lei²,

Zhang³

et al. 2022

IJN

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Inflammation is a beneficial and physiological process, but there are a number of inflammatory diseases which have detrimental effects on the body. In addition, the drugs used to treat inflammation have toxic side effects when used over a long period of time. Mesenchymal stem cells (MSCs) are pluripotent stem cells that can be isolated from a variety of tissues and can be differentiate into diverse cell types under appropriate conditions. They also exhibit noteworthy anti-inflammatory properties, providing new options for the treatment of inflammatory diseases. The therapeutic potential of MSCs is currently being investigated for various inflammatory diseases, such as kidney injury, lung injury, osteoarthritis (OA), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). MSCs can perform multiple functions, including immunomodulation, homing, and differentiation, to enable damaged tissues to form a balanced inflammatory and regenerative microenvironment under severe inflammatory conditions. In addition, accumulated evidence indicates that exosomes from extracellular vesicles of MSCs (MSC-Exos) play an extraordinary role, mainly by transferring their components to recipient cells. In this review, we summarize the mechanism and clinical trials of MSCs and MSC-Exos in various inflammatory diseases in detail, with a view to contributing to the treatment of MSCs and MSC-Exos in inflammatory diseases.

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Mesenchymal stem cells, exosomes and exosome-mimics as smart drug carriers for targeted cancer therapy

Cited by 32 publications

References 179 publications

Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy

Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy

Research Progress of MicroRNAs in Spinal Cord Injury

Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics

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