Mesenchymal stromal cells-based therapy in a murine model of elastase-induced emphysema: Simvastatin as a potential adjuvant in cellular homing

Faria, Carolina Arruda de; Júnior, Wilson A. Silva; Coelho, Karoline Brito Caetano Andrade; Bassi, Mirian; Colombari, Eduardo; Zanette, Dalila Lucíola; Ribeiro-Paes, João Tadeu

doi:10.1016/j.pupt.2021.102075

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Target tissue microenviroment, homing and engraftment of the transplanted cells Another important aspect that is still debatable refers to possible pathophysiological conditions of donor patients (i.e. heterologous infusions), recipient patients as a whole and target tissue, which may be an inhospitable microenvironment that can compromise the homing, engraftment, viability and survival of transplanted cells [103][104][105][106][107][108]. Considering that survival and viability of MSCs in target tissue are key factors for the success of cell-based therapies, the biochemical and molecular regulatory mechanisms that are involved in homing and engraftment processes need to be precisely defined to improve the therapeutic efficacy of these cells [103][104][105][106][107][108][109].…”

Section: Route and Multiple Infusionsmentioning

confidence: 99%

“…heterologous infusions), recipient patients as a whole and target tissue, which may be an inhospitable microenvironment that can compromise the homing, engraftment, viability and survival of transplanted cells [103][104][105][106][107][108]. Considering that survival and viability of MSCs in target tissue are key factors for the success of cell-based therapies, the biochemical and molecular regulatory mechanisms that are involved in homing and engraftment processes need to be precisely defined to improve the therapeutic efficacy of these cells [103][104][105][106][107][108][109]. In addition to these aspects, in the case of COPD, the possible influence of pharmacological therapies, such as bronchodilators and corticosteroids, needs to be considered.…”

Section: Route and Multiple Infusionsmentioning

confidence: 99%

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Regenerative and translational medicine in COPD: hype and hope

Guarnier,

Moro,

Lívero

et al. 2023

Eur Respir Rev

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COPD is a common, preventable and usually progressive disease associated with an enhanced chronic inflammatory response in the airways and lung, generally caused by exposure to noxious particles and gases. It is a treatable disease characterised by persistent respiratory symptoms and airflow limitation due to abnormalities in the airways and/or alveoli. COPD is currently the third leading cause of death worldwide, representing a serious public health problem and a high social and economic burden. Despite significant advances, effective clinical treatments have not yet been achieved. In this scenario, cell-based therapies have emerged as potentially promising therapeutic approaches. However, there are only a few published studies of cell-based therapies in human patients with COPD and a small number of ongoing clinical trials registered onclinicaltrials.gov. Despite the advances and interesting results, numerous doubts and questions remain about efficacy, mechanisms of action, culture conditions, doses, timing, route of administration and conditions related to homing and engraftment of the infused cells. This article presents the state of the art of cell-based therapy in COPD. Clinical trials that have already been completed and with published results are discussed in detail. We also discuss the questions that remain unanswered about cell-based regenerative and translational medicine for COPD.

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Section: Route and Multiple Infusionsmentioning

confidence: 99%

Section: Route and Multiple Infusionsmentioning

confidence: 99%

Regenerative and translational medicine in COPD: hype and hope

Guarnier,

Moro,

Lívero

et al. 2023

Eur Respir Rev

Self Cite

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Stem Cells/Lung Organoids and Lung Rejuvenation in the Treatment of Chronic Obstructive Pulmonary Disease and Pulmonary Emphysema

Nucera,

Hansbro,

Fairley

et al. 2024

Comprehensive Hematology and Stem Cell Research

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A Brief History of Cell Culture: From Harrison to Organs-on-a-Chip

Moro,

Guarnier,

Azevedo

et al. 2024

Cells

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This comprehensive overview of the historical milestones in cell culture underscores key breakthroughs that have shaped the field over time. It begins with Wilhelm Roux’s seminal experiments in the 1880s, followed by the pioneering efforts of Ross Granville Harrison, who initiated groundbreaking experiments that fundamentally shaped the landscape of cell culture in the early 20th century. Carrel’s influential contributions, notably the immortalization of chicken heart cells, have marked a significant advancement in cell culture techniques. Subsequently, Johannes Holtfreter, Aron Moscona, and Joseph Leighton introduced methodological innovations in three-dimensional (3D) cell culture, initiated by Alexis Carrel, laying the groundwork for future consolidation and expansion of the use of 3D cell culture in different areas of biomedical sciences. The advent of induced pluripotent stem cells by Takahashi and Yamanaka in 2006 was revolutionary, enabling the reprogramming of differentiated cells into a pluripotent state. Since then, recent innovations have included spheroids, organoids, and organ-on-a-chip technologies, aiming to mimic the structure and function of tissues and organs in vitro, pushing the boundaries of biological modeling and disease understanding. In this review, we overview the history of cell culture shedding light on the main discoveries, pitfalls and hurdles that were overcome during the transition from 2D to 3D cell culture techniques. Finally, we discussed the future directions for cell culture research that may accelerate the development of more effective and personalized treatments.

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Mesenchymal stromal cells-based therapy in a murine model of elastase-induced emphysema: Simvastatin as a potential adjuvant in cellular homing

Cited by 3 publications

References 46 publications

Regenerative and translational medicine in COPD: hype and hope

Regenerative and translational medicine in COPD: hype and hope

Stem Cells/Lung Organoids and Lung Rejuvenation in the Treatment of Chronic Obstructive Pulmonary Disease and Pulmonary Emphysema

A Brief History of Cell Culture: From Harrison to Organs-on-a-Chip

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