Mesenchymal stromal cells for treatment of arthritis

Swart, J.F.; Wulffraat, NM

doi:10.1016/j.berh.2014.10.023

Cited by 19 publications

(14 citation statements)

References 93 publications

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“…Bone marrow mesenchymal stem cells are easily obtained from various sources and present a strong proliferationcapacity (Tatullo et al, 2015). In recent years, mesenchymal stem cells have been induced to differentiate into specific neurons such as cholinergic neurons, dopaminergic neurons, amino acid neurons, and peptidergic neurons (Woodbury et al, 2000;Fukuda, 2001;Notaraand Ahmed, 2012;Wu et al, 2013;Kristjanssonand Honsawek, 2014;Swart and Wulffraat, 2014;Zhang et al, 2014). Recent studies showed that bone marrow mesenchymal stem cells can survive in the damaged brain tissue and spinal cord, proliferate, migrate, and differentiate into neuron-like cells, thereby effectively improving the neurological function and survival status of patients following spinal cord injuries, stroke, and other nervous system diseases (Widgerow et al, 2013;Chen et al, 2014;Mizukami and Yagihashi, 2014).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of neural differentiation of bone marrow mesenchymal stem cells by different induction methods

Zhao

2015

Genet. Mol. Res.

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ABSTRACT. Neurogenic differentiation of bone marrow (BM) mesenchymal stem cells (MSCs) offers a new hope for patients with many neurological disorders. Several chemical inducers are employed to induce BMMSCs differentiation into nerve cells. In the present study, we compared different inducers [2-mercaptoethanol (BME), tretinoin (ATRA), dimethyl sulfoxide/ butylated hydroxyanisole (DMSO/BHA), and indomethacin/3-isobutyl-1-methylxanthine (indomethacin/IBMX)] on the neurogenic differentiation of BMMSCs and aimed to identify a more efficient and safer method. The MSCs were first identified by their ability to adhere to plastic and by the expression of positive (CD44, CD90, and CD105) and negative (CD34) markers assessed by flow cytometry. The efficiency of the neurogenic differentiation was determined by assessing the mRNA and protein expression of nestin, microtubule-associated protein-2 (MAP2), neuron specific enolase (NSE), and glial fibrillary acidic protein (GFAP) by reverse transcription-polymerase chain reaction and western-blot, respectively. The effect of these inducers on cell viability was also evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. This comprehensive study shows that indomethacin/IBMX is better than BME, DMSO/BHA, and ATRA both in terms of efficiency and safety, while BME suppressed the growth and proliferation of MSCs.

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Section: Introductionmentioning

confidence: 99%

Comparative study of neural differentiation of bone marrow mesenchymal stem cells by different induction methods

Zhao

2015

Genet. Mol. Res.

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“…MSC are clinically interesting for their regenerative properties and they found ample applications regarding liver [14], cardiovascular [15], musculoskeletal and orthopaedic [16] (including cartilages defects following trauma [17], osteoarthritis [18], rheumatoid arthritis [19], osteoporosis, osteonecrosis and osteogenesis imperfecta [20], degenerative disc disease [21]), neurological (including amyotrophic lateral sclerosis (SLA) [22,23] and Alzheimer's disease [24]), renal and autoimmune diseases [25,26].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic immunomodulation with mesenchymal stromal cells: the need for in vivo clues

Dolcetti

Dazzi

2015

IJTS

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Mesenchymal stem/stromal cells are effective therapeutic agents for a variety of pathological conditions. However, the molecular mechanisms underlying their action remain largely unknown and biased by in vitro studies. In this concise review we have described recent advances in MSC therapeutics based on in vivo observations. We have also discussed the possibility of using engineering approaches to improve and facilitate deciphering MSC functions.

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“…Other data derive from studies on osteoarthritis: human osteophytes have shown them to contain cells exhibiting a mesenchymatous cell phenotype and probably originating in the periosteum (58,59 The regenerative, immunosuppressive and anti-inflammatory properties of cultured MSCs led to the development of trials for their therapeutic potential in preclinical models of inflammatory arthritis. As discussed above, several studies suggested that bone marrow-or adipose-derived MSCs have the ability to reset the immune system by reducing the pro-inflammatory Th1/Th17 response and enhancing the protective regulatory T cell response (61). Bone marrow has been the historic source site of MSCs and is the best studied.…”

Section: Immunoregulationmentioning

confidence: 99%

Mesenchimal stem cells: a possible role in the pathogenesis and treatment of spondyloarthritis

et al. 2017

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SUMMARY Spondyloarthritis (SpAs) are a group of chronic inflammatory diseases that affect joints and enthesis with a possible involvement of other districts such as skin, eye and bowel. In SpAs, the inflammatory process could lead to both erosive damage (as in peripheral joint involvement of psoriatic arthritis), or bone formation (as in ankylosing spondylitis) with a reduction in function and quality of life. Recently, Mesenchimal stem cells (MSCs) transplant was used in different diseases, including autoimmune and inflammatory diseases, with the aim of repairing tissue damage, exploiting their regenerative capacity. However, MSCs also proved to have an immune-modulatory capacity due to their interaction with the cells of the immune system. The aim of this brief paper was to review the possible pathogenic role and the new perspective of MSCs use in SpAs.

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Mesenchymal stromal cells for treatment of arthritis

Cited by 19 publications

References 93 publications

Comparative study of neural differentiation of bone marrow mesenchymal stem cells by different induction methods

Comparative study of neural differentiation of bone marrow mesenchymal stem cells by different induction methods

Therapeutic immunomodulation with mesenchymal stromal cells: the need for in vivo clues

Mesenchimal stem cells: a possible role in the pathogenesis and treatment of spondyloarthritis

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