Mesenchymal tumors associated with hypoglycemia:Case report and review of the literature

Anderson, Norwood; Lokich, Jacob J.

doi:10.1002/1097-0142(197908)44:2<785::aid-cncr2820440253>3.0.co;2-s

Cited by 30 publications

(16 citation statements)

References 56 publications

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“…Clinical signs and symptoms reported were: large epigastric mass, loss of body weight, vomiting, and diarrhea. Two patients had hypoglycemia (which has been previously reported in mesenchymal tumors and fibrous mesotheliomas of the pleura) 12,13. In our patient, hypoglycemia was identified preoperatively and had resolved after surgery.…”

Section: Discussionsupporting

confidence: 69%

“…In our patient, hypoglycemia was identified preoperatively and had resolved after surgery. There is little information on possible correlations between hypoglycemia and mesenchymal tumors12,13 and the hypoglycemic mechanism remains unknown. A high molecular weight fraction of nonsuppressible insulin‐like activity (NSILA) has been suggested as a possible etiologic factor in tumor‐induced hypoglycemia 13…”

Section: Discussionmentioning

confidence: 99%

“…The monoclonal antibody CD 34 has recently received wide consensus for the characterization of SFT . It is a 110‐kDa glycosylated transmembrane protein of unknown function, originally described as a marker for human hematopoietic stem cells, and subsequently found to be expressed in numerous neoplasms, including SFT 14.…”

Section: Introductionmentioning

confidence: 99%

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Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia

Guglielmi

Frameglia

Iuzzolino

et al. 1998

Journal of Hepato-Biliary-Pancreatic Surgery

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We report a new case of solitary fibrous tumor (SFT) of the liver, an extremely rare neoplasm. Including the present case no more than ten cases are reported in the English-language literature. To date there is no definite proof of the origin of this tumor. Both mesothelial and fibroblas-tic genesis has been postulated. The monoclonal antibody CD 34 has recently been used for the characterization of SFT. SFT would appear to be histogenetically related to a CD 34 - positive fibroblastic stem cell. A 61-year-old woman was admitted to our department with epigastric and right hypochondriac pain, weight loss, and hypoglycemia. Ultrasonography and computed tomography demonstrated a large heterogeneous mass in the right hepatic lobe. A right hepatectomy was performed. The tumor weighed 2850 g and microscopic section revealed a peculiar random pattern, the so-called patternless pattern of spindle tumor cells separated by abundant thick collagen bands. The tumor presented a number of highly cellular areas composed of plump spindle cell with hyperchromatic nuclei and rare mitotic figures. Ninety percent of the neoplastic cells displayed strong immunoreactivity for CD 34/My 10. The postoperative course was uneventful and the patient is alive and well without recurrence 6 years after surgery.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia

Guglielmi

Frameglia

Iuzzolino

et al. 1998

Journal of Hepato-Biliary-Pancreatic Surgery

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“…Hypoglycemia associated with extrapancreatic neo¬ plasia in man is rare, and is most commonly observed in malignant tumors of mesenchymal origin (1).…”

mentioning

confidence: 99%

Hypoglycemia in a dog with a leiomyoma of the gastric wall producing an insulin-like growth factor II-like peptide

Boari

Barreca

et al. 1995

European Journal of Endocrinology

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A 12-year-old mixed-breed male dog was referred to the Clinica Medica Veterinaria of Bologna University for recurrent episodes of seizures due to hypoglycemia with abnormally low plasma insulin levels (18 pmol/l). Resection of a large leiomyoma (780 g) of the gastric wall resulted in a permanent resolution of the hypoglycemic episodes. Insulin-like growth factors I and II (IGF-I and -II) were measured by RIA in serum before and after surgery and in tumor tissue. Results were compared to the serum concentration of 54 normal and to the tissue concentration observed in eight non-hypoglycemic dog gastric wall extracts. Before surgery, circulating immunoreactive IGF-I was 0.92 nmol/l, which is significantly lower than the control values (16.92 +/- 8.44 nmol/l, range 3.53-35.03), while IGF-II was 152 nmol/l, which is significantly higher than the control values (42.21 +/- 3.75, range 31.99-50.74). After surgery, IGF-I increased to 6.80 nmol/l while IGF-II decreased to 45.52 nmol/l. Tumor tissue IGF-II concentration was higher than normal (5.66 nmol/kg tissue as compared to a range in normal gastric wall tissue of 1.14-3.72 nmol/kg), while IGF-I was 0.08 nmol/kg tissue, which is close to the lowest normal value (range in controls, 0.08-1.18 nmol/kg). Partial characterization of IGF-II immunoreactivity extracted from tissue evidenced a molecular weight similar to that of mature IGF-II, thus excluding that peptide released by the tumor is a precursor molecule.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Non-islet cell tumour hypoglycaemia is a rare paraneoplastic phenomenon seen classically with large mesenchymal tumours, such as fibrosarcomas, mesotheliomas, leiomyosarcomas, gastrointestinal stromal tumours and haemangiopericytomas 1 2 4. However, it can also be seen in epithelial tumours particularly hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%