Mesenteric lipoblastoma presenting as a segmental volvulus

A giant mesenteric lipoblastoma in an 18-month old infant: A case report and review of the literature

“…[16] The age distribution of all these children with mesenteric lipoblastomas (including our case) is from 5 months to 7 years old with a male predilection. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] The exact aetiology is not known. [10] Although most cases are asymptomatic at presentation, lipoblastomas can present, as in our case, with a palpable abdominal mass and progressive abdominal distention, when originated at the ileum mesentery; however, on the other side with bilious vomiting, loss of appetite, mild abdominal pain or diarrhea for jejunal and ileocecal valve mesenteric lipoblastomas.…”

“…In addition, gene rearrangement and subsequent upregulation of the development of zinc-finger gene PLAG1 is common in lipoblastoma, but not in other lipogenic tumors. [12] The most difficult differential diagnosis is with liposarcoma, mainly its myxoid type. Liposarcoma is extremely rare under 10 years old, and it is histologically diagnosed by lack of lobulation, variable growth pattern, increased nuclear atypia, and abnormal mitoses.…”

“…Liposarcoma is extremely rare under 10 years old, and it is histologically diagnosed by lack of lobulation, variable growth pattern, increased nuclear atypia, and abnormal mitoses. [12] In histologically borderline cases, the tumor karyotype establishes an accurate diagnosis. Chromosomal translocations within chromosome 8 are a specific marker for lipoblastoma.…”

“…[1] However, in order not to confuse the readers, the term "lipoblastoma" is used throughout the manuscript since this term has been widely used in previous reports. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] It presents in two forms, a well-encapsulated one, called lipoblastoma Case Report and a diffuse one, known as lipoblastomatosis. It usually presents in children below 7 years of age, while 6 of them were <2 years old.…”

“…It usually presents in children below 7 years of age, while 6 of them were <2 years old. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] While it is primarily located in the soft tissues of the extremities and trunk, it is more rarely seen in the neck, face, buttock, perirectal area, and abdomen, and it is extremely rare in the abdominal mesentery and even more rare in the ileum mesentery. We report an 18-month old boy presenting with a palpable intraabdominal mass arising from the ileum mesentery.…”